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 Allergy Advisor Digest - August 2016
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Read Measuring local immunoglobulin E in the inferior turbinate nasal mucosa in patients with allergic rhinitis.
Read Specific IgE sensitization to honey bee venom and auto-injector adrenaline prescriptions for Japanese beekeepers.
Read Anaphylaxis to Japanese butterbur scapes (Petasites japonicus).
Read Anaphylaxis provoked by ingestion of hydrolyzed fish collagen probably induced by epicutaneous sensitization.
Read A. fumigatus components distinguish IgE but not IgG4 profiles between fungal sensitization and ABPA.
Read Application of recombinant antigen 5 allergens from seven allergy-relevant Hymenoptera species in diagnostics.
Read Transcriptomic/proteomic identification of allergens in the mite Tyrophagus putrescentiae.
Read Prevalence and clinical features of adverse food reactions in Portuguese adults.
Read Reproducibility of serum IgE, Ara h2 skin prick testing and fraction of exhaled nitric oxide for predicting clinical peanut allergy in children.
Read Clinical and immuno-proteomic approach on Lantana camara pollen allergy-a major health hazard.
Read New allergen sensitization might be associated with increased body mass index in children.
Read Methods of ingestion in oral food challenge tests using whole-egg powder.
Read Delayed diagnosis of allergic bronchopulmonary aspergillosis due to absence of asthmatic symptoms.
Read Aeroallergen sensitization and allergic disease phenotypes in Asia.
Read Genetic Polymorphisms and Allergenicity of Blo t 5 in a House Dust Mite Allergic Filipino Population.
Read Species and quantity of airborne pollens in Shanghai as monitored by gravitational and volumetric methods.
Read Skin testing with beta-lactam Antibiotics for Diagnosis of beta-lactam Hypersensitivity in Children.
Read Metabolomic analysis identifies potential diagnostic biomarkers for aspirin-exacerbated respiratory disease.
Read Drug induced exfoliative dermatitis: state of the art.
Read Hypersensitivity pneumonitis due to metalworking fluid aerosols.
Read Impact of changed legislation on skin tests: the present and future.
Read Allergic manifestations of contact lens wearing.
Read Should patients with pollen fruit syndrome be prescribed an automatic epinephrine injector?
Read Hypersensitivity reactions to heparins.
Read Real-life study for the diagnosis of house dust mite allergy - the value of recombinant allergen-based IgE serology.
Read Reactions to Rituximab in an Outpatient Infusion Center: A 5-Year Review.
Read Early oral exposure to house dust mite allergen through breast milk: a potential risk factor for allergic sensitization and respiratory allergies in children.
Read Randomized controlled trial of early regular egg intake to prevent egg allergy.
Read Allergenicity and safety of recombinant human C1 esterase inhibitor in patients with allergy to rabbit or cow's milk.
Read The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart.
Read Egg Sensitisation, Allergy and Component Patterns in African Children with Atopic Dermatitis.
Read Cross-reactivity in allergic fungal sinusitis. Case report.
Read Men and cypress

Abstracts shared in August 2016 Advisor Digest Newsletter

Read Recent advances in component resolved diagnosis in food allergy.
Read Allergy to fish collagen: Thermostability of collagen and IgE reactivity of patients' sera with extracts of 11 species of bony and cartilaginous fish.
Read Association of tree nut and coconut sensitization.
Read A case of anaphylaxis in the pediatric patient with milk allergy due to traces of milk protein in the lactose used as an excipient of inavir inhalation.
Read Marking nut anaphylaxis.
Read Age of Resolution from IgE-Mediated Wheat Allergy.
Read Effects of maternal dietary egg intake during early lactation on human milk ovalbumin concentration: a randomized controlled trial.
Read sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitised to cashew nuts.
Read Scombroid syndrome: it seems to be fish allergy but... it isn't.
Read EAACI Molecular Allergology User's Guide.
Read Allergy to peach with negative serum peach-specific IgE.

Allergy and Intolerance Abstracts
Measuring local immunoglobulin E in the inferior turbinate nasal mucosa in patients with allergic rhinitis.
Our results evaluating the correlations between nasal mucosal and serum levels of antigen-specific IgE indicate that IgE produced in the nasal mucosa affects the IgE levels in the serum, especially the cedar pollen-specific IgE

Measuring local immunoglobulin E in the inferior turbinate nasal mucosa in patients with allergic rhinitis.  
Ota Y, Ikemiyagi Y, Sato T, Funakoshi T, Hiruta N, Kitamura M, Bujo H, Suzuki M.
Allergol Int 2016 Aug 8;

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Allergy and Intolerance Abstracts
Specific IgE sensitization to honey bee venom and auto-injector adrenaline prescriptions for Japanese beekeepers.
Approximately 11% of Japanese beekeepers with sIgE to honey bee venom and 29% who had experienced systemic reactions to a honey bee sting and showed sIgE to the venom were prescribed adrenaline auto-injectors. Moreover, approximately 35% of beekeepers usually carry auto-injectors during work, regardless of the presence or absence of systemic reactions to honey bee stings. This study suggests that the owners of the cooperative should consider obtaining adrenaline autoinjector prescriptions for beekeepers who have sIgE Ab to honey bee and/or hornet venom. In addition, beekeepers should be educated about regularly carrying adrenalin auto-injectors

Specific IgE sensitization to honey bee venom and auto-injector adrenaline prescriptions for Japanese beekeepers.  
Hirata H, Tatewaki M, Shiromori S, Ikeno Y, Akutsu I, Sugiyama K, Arima M, Kurasawa K, Fukuda T, Shima D, Fukushima Y.
Allergol Int 2016 Aug 8;

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Allergy and Intolerance Abstracts
Anaphylaxis to Japanese butterbur scapes (Petasites japonicus).
Two cases of anaphylaxis to Japanese butterbur scapes. Patient no. 1 had ingested Japanese butterbur scape tempura. Thirty minutes later, she developed urticaria with intense itching over the entire body and dyspnea. Patient no. 2 had urticaria over her whole body and dyspnea following ingestion of Japanese butterbur scape tempura. The symptoms of both patients disappeared after emergency treatment. Both patients had never experienced an allergic reaction to butterbur scapes before these episodes. Prick test results were found to be positive for Japanese butterbur scapes and other Asteraceae plants, including chrysanthemum and dandelion.

Anaphylaxis to Japanese butterbur scapes.  
Kataoka Y, Tamagawa-Mineoka R, Masuda K, Katoh N.
Allergol Int 2016 Jul 19;

Index
Allergy and Intolerance Abstracts
Anaphylaxis provoked by ingestion of hydrolyzed fish collagen probably induced by epicutaneous sensitization.
Large amount of products derived from fish collagen, such as gelatin, hydrolyzed fish collagen and atelocollagen, are consumed as dietary supplement, sweets, cosmetics and moisturizers today. We report a patient with atopic dermatitis who experienced episodes of anaphylaxis after ingestion of dietary supplement or gummy candy, both of which contained the hydrolyzed fish collagen sold under a trade name “fish collagen peptide” even though it contained high molecular weight proteins. The patient started applying a moisturizer containing fish atelocollagen on her face 15 months before the first episode of anaphylaxis. We speculate that long term application of the moisturizer on impaired skin surface induced epicutaneous sensitization of fish collagen. Every episode occurred within several minutes after consuming 1 package of the dietary supplement with development of lip swelling, itching of eyes, throat and genitalia, and airway constriction. the patient's serum reacted with ~140 kDa protein of fish atelocollagen and 120 kDa protein of gelatin from fish collagen, and weakly with gelatin derived from bovine bone, but not with proteins of gelatin from porcine skin nor hydrolyzed fish collagen, “fish collagen peptide”, supplied by company A. The levels of specific IgE antibodies by Immuno-CAP specific IgE were: 21.2 UA/ml for gelatin from cold water fish skin, 4.97 UA/ml for bovine gelatin, and below 0.1 UA/ml for both carp parvalbumin (Cyp c 1) and cod parvalbumin (Gdc c 1). (Wataru 2016 ref.32175 3)

Anaphylaxis provoked by ingestion of hydrolyzed fish collagen probably induced by epicutaneous sensitization.  
Wataru Fujimoto, Mikiko Fukuda, Tomoharu Yokooji, Takahiro Yamamoto, Akira Tanaka, Hiroaki Matsuo.
Allergol Int 2016 July 25;

Abstract

Index
Allergy and Intolerance Abstracts
A. fumigatus components distinguish IgE but not IgG4 profiles between fungal sensitization and ABPA.
Aspergillus fumigatus is the causative agent of allergic broncho-pulmonary aspergillosis. Prompt and accurate diagnosis may be difficult to achieve with current clinical and laboratory scores, which do not include immune responses to recombinant A. fumigatus allergens. We measured specific immunoglobulin E and G4 directed to recombinant A. fumigatus allergens in fifty-five cystic fibrosis patients without allergic broncho-pulmonary aspergillosis but sensitized to A. fumigatus and in nine patients with allergic broncho-pulmonary aspergillosis (two with cystic fibrosis and seven asthmatics). IgG4 responses to recombinant A. fumigatus allergens were detected in all patients, but neither prevalence nor levels were different between the two patient groups. On the other hand, both prevalence and levels of IgE responses to Asp f 3, Asp f 4 and Asp f 6 helped distinguish allergic broncho-pulmonary aspergillosis from A. fumigatus sensitization with good negative and positive predictive values.

A. fumigatus components distinguish IgE but not IgG4 profiles between fungal sensitization and ABPA.  
Vitte J, Romain T, Carsin A, Gouitaa M, Stremler-Le BN, Baravalle-Einaudi M, Cleach I, Reynaud-Gaubert M, Dubus JC, Mege JL.
Allergy 2016 Aug 19;

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Allergy and Intolerance Abstracts
Application of recombinant antigen 5 allergens from seven allergy-relevant Hymenoptera species in diagnostics.
To address immunological IgE cross-reactivity on molecular level, seven recombinant antigens 5 of the most important Vespoidea groups were assessed by different diagnostic setups. The antigens 5 of yellow jackets, hornets, European and American paper wasps, fire ants, white-faced hornets, and Polybia wasps were recombinantly produced in insect cells, immunologically and structurally characterized, and their sIgE reactivity assessed by ImmunoCAP, ELISA, cross-inhibition, and basophil activation test (BAT) in patients with yellow jacket or Polistes venom allergy of two European geographical areas. All recombinant allergens were correctly folded and structural models and patient reactivity profiles suggested the presence of conserved and unique B-cell epitopes. All antigens 5 showed extensive cross-reactivity in sIgE analyses, inhibition assays, and BAT. This cross-reactivity was more pronounced in ImmunoCAP measurements with venom extracts than in sIgE analyses with recombinant antigens 5. Dose-response curves with the allergens in BAT allowed a differentiated individual dissection of relevant sensitization. Due to extensive cross-reactivity in various diagnostic settings, antigens 5 are inappropriate markers for differential sIgE diagnostics in vespid venom allergy. However, the newly available antigens 5 from further vespid species and the combination of recombinant allergen-based sIgE measurements with BAT represents a practicable way to diagnose clinically relevant sensitization in vespid venom allergy.

Application of recombinant antigen 5 allergens from seven allergy-relevant Hymenoptera species in diagnostics.  
Schiener M, Eberlein B, Moreno-Aguilar C, Pietsch G, Serrano P, McIntyre M, Schwarze L, Russkamp D, Biedermann T, Spillner E, Darsow U, Ollert M, Schmidt-Weber CB, Blank S.
Allergy 2016 Aug 6;

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Allergy and Intolerance Abstracts
Transcriptomic/proteomic identification of allergens in the mite Tyrophagus putrescentiae.
Next-generation sequencing was combined with MS/MS shotgun proteomics to identify proteins, especially potential allergens from Tyrophagus putrescentiae, commonly found in stored food products, especially flour. cDNAs of suspected allergens were cloned and expressed from bacterial cells, and recombinant allergens were tested for binding to IgE in sera from T. putrescentiae-sensitive patients. These analyses identified three previously uncharacterized allergens, Tyr p 28, Tyr p 35, and Tyr p 36, which have been officially assigned by the WHO/IUIS Allergen Nomenclature Sub-committee. Recombinant proteins rTyr p 28, rTyr p 35, and rTyr p 36 bound with 47.1%, 82.4%, and 70.6% of T. putrescentiae-sensitive sera.

Transcriptomic/proteomic identification of allergens in the mite Tyrophagus putrescentiae.  
Cui Y, Yu L, Teng F, Zhang C, Wang N, Yang L, Zhou Y.
Allergy 2016 Aug 6;

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Allergy and Intolerance Abstracts
Prevalence and clinical features of adverse food reactions in Portuguese adults.
Population-based, cross-sectional study performed in various healthcare centres from central Portugal. All 1436 randomly selected individuals (median age: 45 years, 50.6 % female) replied to a validated food allergy questionnaire by phone. Those who reported an adverse food reaction were invited to come to the hospital, where clinical history was taken, skin prick (SPT) and prick-prick skin (SPPT) tests were performed and food allergen-specific IgE levels (sIgE) were determined. An open oral challenge was performed in selected cases. The prevalence of probable food allergy in the sample was 1 %, with shellfish and fish as the most frequently implicated foods. IgE-mediated probable food allergy occurred in 0.71 % of cases, with shellfish, peanut and nuts mainly involved. Cutaneous symptoms were most frequently reported. Prevalence values and food types were discrepant between self-reported and probable food allergies.

Prevalence and clinical features of adverse food reactions in Portuguese adults.  
Lozoya-Ibanez C, Morgado-Nunes S, Rodrigues A, Lobo C, Taborda-Barata L.
Allergy Asthma Clin Immunol 2016;1236

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Allergy and Intolerance Abstracts
Reproducibility of serum IgE, Ara h2 skin prick testing and fraction of exhaled nitric oxide for predicting clinical peanut allergy in children.
In this population, Ara h2 SPT was no worse in accuracy when compared with current testing for the evaluation of clinical peanut allergy, but had-like peanut SPT-poor reproducibility. FeNO, peanut sIgE and Ara h2 sIgE were consistently reproducible despite an interval of at least 12 months between the repeated measurements

Reproducibility of serum IgE, Ara h2 skin prick testing and fraction of exhaled nitric oxide for predicting clinical peanut allergy in children.  
Percival E, Bhatia R, Preece K, McElduff P, McEvoy M, Collison A, Mattes J.
Allergy Asthma Clin Immunol 2016;1235

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Allergy and Intolerance Abstracts
Clinical and immuno-proteomic approach on Lantana camara pollen allergy-a major health hazard.
The most dominant pollen responsible for IgE sensitivity in most patients in India emerged to be from Lantana camara (LC) an obnoxious weed growing in and around suburban areas of West Bengal. In this study, allergenic components from this shrub using an immunoproteomic approach were identified. Lantana camara pollen emerged as a significant contributor from the correlation study with hospital admission of the respiratory allergy sufferers and its extract demonstrated an elevated IgE response in ELISA and histamine release assay tests. Five IgE reactive bands/zones were observed in 1D blot which resolved to 12 allergo-reactive spots in the 2D blot. Mass spectrometric analysis identified nine spots that grouped into four diverse proteins. Pathogenesis-related Thaumatin-like protein was found to be one of the major allergens in Lantana camara.

Clinical and immuno-proteomic approach on Lantana camara pollen allergy-a major health hazard.  
Ghosal K, Saha B, Gupta BS.
Allergy Asthma Clin Immunol 2016;1233

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Allergy and Intolerance Abstracts
New allergen sensitization might be associated with increased body mass index in children.
This study concludes that children who became newly sensitized to allergens tended to exhibit significant increases in BMI. Therefore, further evaluation of the relationship between obesity and allergy is needed. Four hundred fourteen children (boys to girls, 208 to 206) were included. Among 414 participants, 73 children showed new sensitization and 24 children showed negative conversion of allergic sensitization after 2 years. One hundred sixty-one children showed positive results on both tests, and 156 children showed negative results on both tests. The mean (standard deviation) change in BMI (1.09 +/- 1.81 kg/m(2)) over a 2-year follow-up in newly sensitized children was significantly greater than that of other groups (p = 0.008).

New allergen sensitization might be associated with increased body mass index in children.  
Lee EJ, Kim JH, Lee KH, Hong SC, Lee HS, Kang JW.
Am J Rhinol Allergy 2016 Jul;30(4):124-127

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Allergy and Intolerance Abstracts
Methods of ingestion in oral food challenge tests using whole-egg powder.
This Japanese study prospectively examined the results of an inpatient oral food challenge test involving the use of juice containing whole-egg powder (egg juice) (equivalent to half of an egg) OFC test conducted in 116 cases for diagnosis or tolerance acquisition. The OFC test positivity rate was 33%. Severity according to the anaphylaxis guidelines was grade 1 (mild; 42%), grade 2 (moderate; 53%), and grade 3 (severe; 5%) in the patients with positive test results. Among the 78 subjects with negative results for intakes at home, 92% had no symptoms, with the remaining 8% having mild symptoms but requiring no treatment. We could confirm later that all the patients could eat foods containing half of a chicken egg. For the subjects with negative egg-juice OFC test results, eating egg products equivalent to half of an egg at home seemed to be relatively safe

Methods of ingestion in oral food challenge tests using whole-egg powder. [Japanese]  
Yanagida N, Sato S, Ebisawa M.
Arerugi 2016 May;65(3):193-199

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Allergy and Intolerance Abstracts
Delayed diagnosis of allergic bronchopulmonary aspergillosis due to absence of asthmatic symptoms.
Allergic bronchopulmonary aspergillosis (ABPA) is a pulmonary disease with small prevalence. Exposure to aspergillus mold causes immunologic hypersensitivity and may cause ranges of symptoms from minimal to detrimental outcomes. Diagnosing and treating the disease before the development of bronchiectasis may save the patient from poor outcomes. This report presents a case of recurrent ABPA without any symptom of asthma, which impeded the correct diagnosis even after numerous hospitalizations

Delayed diagnosis of allergic bronchopulmonary aspergillosis due to absence of asthmatic symptoms.  
Kim Y, Lee HY, Gu KM, Lee JY, Yoon SW, Park TY, Choi JC, Kim JY, Park IW, Shin JW, Choi BW, Jung JW.
Asia Pac Allergy 2016 Jul;6(3):187-191

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Allergy and Intolerance Abstracts
Aeroallergen sensitization and allergic disease phenotypes in Asia.
Pollen and animal dander affect less than 10% of Asian patients as compared to 40-70% of individuals with asthma and allergic rhinitis living in the West, a burden almost equivalent to the dust mite burden in those regions. There is thus a pressing need for preventive measures to reduce dust mite sensitization in Asian children today

Aeroallergen sensitization and allergic disease phenotypes in Asia.  
Tham EH, Lee AJ, Bever HV.
Asian Pac J Allergy Immunol 2016 Aug 16;

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Allergy and Intolerance Abstracts
Genetic Polymorphisms and Allergenicity of Blo t 5 in a House Dust Mite Allergic Filipino Population.
Blo t 5 gene exhibits polymorphic variants with predicted amino acid sequences resulting to changes in its IgE epitopes. These polymorphisms may suggest variability of allergenic properties of Blo t 5. The incorporation of the Blo t 5 variants in the panel of diagnostic allergens and immunotherapy is highly recommended

Genetic Polymorphisms and Allergenicity of Blo t 5 in a House Dust Mite Allergic Filipino Population.  
Medina LR, Malainual N, Ramos JD.
Asian Pac J Allergy Immunol 2016 Aug 16;

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Allergy and Intolerance Abstracts
Species and quantity of airborne pollens in Shanghai as monitored by gravitational and volumetric methods.
Two methods were used simultaneously for the first time to monitor pollen counts in central urban Shanghai, showing a 2 peak-distribution. Broussonetia and Humulus were predominant spring and autumn pollens, respectively. Pollen counts obtained by both methods were clearly correlated. Regional airborne pollen monitoring offers preventive measures for sensitized individuals, providing useful clinical information.

Species and quantity of airborne pollens in Shanghai as monitored by gravitational and volumetric methods.  
Sun L, Xu Y, Wang Y, Lou Y, Xu Y, Guo Y.
Asian Pac J Allergy Immunol 2016 Aug 16;

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Allergy and Intolerance Abstracts
Skin testing with beta-lactam Antibiotics for Diagnosis of beta-lactam Hypersensitivity in Children.
Among those children with a history of beta-lactam hypersensitivity, skin testing with penicillin G, ampicillin, amoxicillin-clavulanic acid, and the suspect beta-lactam was safe and provided a good NPV when PPL and MDM were unavailable. However, a skin test with beta-lactam antibiotics alone did not provide a high sensitivity, thus a DPT procedure was necessary in order to confirm the diagnosis of beta-lactam hypersensitivity

Skin testing with beta-lactam Antibiotics for Diagnosis of beta-lactam Hypersensitivity in Children.  
Manuyakorn W, Singvijarn P, Benjaponpitak S, Kamchaisatian W, Rerkpattanapipat T, Sasisakulporn C, Jotikasthira W.
Asian Pac J Allergy Immunol 2016 Aug 16;

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Allergy and Intolerance Abstracts
Metabolomic analysis identifies potential diagnostic biomarkers for aspirin-exacerbated respiratory disease.
To date, there has been no reliable in vitro test to diagnose aspirin-exacerbated respiratory disease (AERD). This study investigated potential diagnostic biomarkers for AERD using metabolomic analysis. An untargeted profile of serum from asthmatics in the first cohort (group 1) comprising 45 AERD, 44 patients with aspirin-tolerant asthma (ATA), and 28 normal controls was developed using the UHPLC/Q-ToF MS system. Metabolites that discriminate AERD from ATA were quantified in both serum and urine, which were collected before (baseline) and after the lysine-aspirin bronchoprovocation test (Lys-ASA BPT). Serum metabolite level of LTE4 and LTE4 /PGF2 alpharatio were identified as potential in vitro diagnostic biomarkers for AERD using the UHPLC/Q-ToF MS system, which were closely associated with major pathogenetic mechanisms underlying AERD.

Metabolomic analysis identifies potential diagnostic biomarkers for aspirin-exacerbated respiratory disease.  
Ban GY, Cho K, Kim SH, Yoon MK, Kim JH, Lee HY, Shin Y, Ye YM, Cho JY, Park HS.
Clin Exp Allergy 2016 Aug 17;

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Allergy and Intolerance Abstracts
Drug induced exfoliative dermatitis: state of the art.
Drug induced exfoliative dermatitis (ED) are a group of rare and severe drug hypersensitivity reactions (DHR) involving skin and usually occurring from days to several weeks after drug exposure. Erythema multiforme (EM), Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are the main clinical presentations of drug induced ED. Overall, T cells are the central player of these immune-mediated drug reactions. This article provides a systematic review on frequency, risk factors, pathogenesis, clinical features and management of patients with drug induced ED

Drug induced exfoliative dermatitis: state of the art.  
Yacoub MR, Berti A, Campochiaro C, Tombetti E, Ramirez GA, Nico A, Di LE, Fantini P, Sabbadini MG, Nettis E, Colombo G.
Clin Mol Allergy 2016;149

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Allergy and Intolerance Abstracts
Hypersensitivity pneumonitis due to metalworking fluid aerosols.
Metalworking fluid exposure has become the commonest recognised cause of occupational hypersensitivity pneumonitis, having been rare before 2000. There are many possible agents in the metalworking fluid which may be the cause of disease including bacteria, mycobacteria, fungae, biocides, emulsifiers, reodorants and dissolved chrome and cobalt. Causes are likely to be different in different outbreaks. Mycobacteria growing in the metalworking fluid have generated immune responses in some workers, but their role in disease causation is not yet established. Many outbreaks have been identified in large workplaces using common sumps. It is not possible to prevent microbial contamination of metalworking fluids in use. Disease prevention should focus on stopping inhalation of aerosols, particularly by re-engineering to remove recirculation

Hypersensitivity pneumonitis due to metalworking fluid aerosols.  
Burge PS.
Curr Allergy Asthma Rep 2016 Aug;16(8):59

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Allergy and Intolerance Abstracts
Impact of changed legislation on skin tests: the present and future.
European Union legislations now define diagnostic allergens to be medicine requiring market authorization of every individual diagnostic allergen with obligations including clinical trials, application dossiers, a regular update of the dossiers, handling of variation processes and ongoing stability testing of the source material and periodic safety update reporting. The financial expenses of the initiation and maintenance of approvals for diagnostic allergens far exceed their related revenues. Thus, the numbers of authorized test allergens are steadily decreasing. The current European Union regulations are anticipated to have an immense impact on in-vivo allergy diagnosis in Europe. Available skin test allergens decreased to less than half of what has been before in recent years. EAACI has addressed both the EU and EMA to resolve this situation

Impact of changed legislation on skin tests: the present and future.  
Klimek L, Hoffmann HJ, Kugler A, Muraro A, Hellings PW.
Curr Opin Allergy Clin Immunol 2016 Aug 17;

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Allergy and Intolerance Abstracts
Allergic manifestations of contact lens wearing.
ontact lens-induced papillary conjunctivitis (CLPC) is a common ocular allergic disease in contact lens wearers. In its more severe form, it can cause giant papillary conjunctivitis, resulting in contact lens intolerance and the need to discontinue the use of contact lenses. This review presents the pathogenesis, clinical manifestations and management guidelines of this common disorder. Different types of contact lenses are associated with differences in the severity of CLPC. Refitting patients with silicone hydrogel contact lenses or with daily disposable contact lenses may improve the signs and symptoms of CLPC. The recent introduction of the topical immunomodulatory agent tacrolimus in other severe allergic eye diseases may apply in suppressing the allergic inflammation in CLPC as well.

Allergic manifestations of contact lens wearing.  
Solomon A.
Curr Opin Allergy Clin Immunol 2016 Aug 11;

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Allergy and Intolerance Abstracts
Should patients with pollen fruit syndrome be prescribed an automatic epinephrine injector?
Despite improvement in diagnostic tests, there remains no completely reliable way to determine whether an individual with pollen fruit syndrome is at risk of a systemic reaction. The decision to prescribe an epinephrine autoinjector must be based on a risk assessment for the individual patient

Should patients with pollen fruit syndrome be prescribed an automatic epinephrine injector?  
Katelaris CH.
Curr Opin Allergy Clin Immunol 2016 Aug;16(4):370-374

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Allergy and Intolerance Abstracts
Hypersensitivity reactions to heparins.
Delayed skin lesions after subcutaneous heparin are the most common type of hypersensitivity reactions, followed by life-threatening heparin-induced thrombocytopenia. Immediate reactions are uncommon. Allergologic studies may be useful to find an alternative option in patients with skin lesions in which heparin-induced thrombocytopenia has been previously excluded, as well as in heparin immediate reactions.

Hypersensitivity reactions to heparins.  
Gonzalez-Delgado P, Fernandez J.
Curr Opin Allergy Clin Immunol 2016 Aug;16(4):315-322

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Allergy and Intolerance Abstracts
Real-life study for the diagnosis of house dust mite allergy - the value of recombinant allergen-based IgE serology.
Dermatophagoides pteronyssinus is one of the most important perennial allergen sources worldwide. Molecular diagnostics using the commercially available major allergens (Der p 1 and Der p 2) in combination with Der p 10 do not detect house dust mite (HDM) sensitization in a number of cases when used alone. The objective was to evaluate the IgE reactivity profiles of these patients using an experimental immunoassay biochip. Of 97 patients tested, 16 showed negative results to Der p 1, Der p 2, and Der p 10. MeDALL chip evaluation revealed 5 patients monosensitized to Der p 23, and 11 patients were negative for all HDM MeDALL chip components. Seven sera were available for further testing, and 3 of them showed IgE reactivity to dot-blotted nDer p 1, and 2 reacted with high-molecular weight components (>100 kDa) in nitrocellulose-blotted HDM extract when tested with 125I-labeled anti-IgE in a RAST-based assay. The HDM extract-specific IgE levels of the 11 patients were <3.9 kU/l. Therefore recombinant allergen-based IgE serology is of great value when conventional IgE diagnostics fails. Der p 23 is an important HDM allergen, especially when major allergens are negative.

Real-life study for the diagnosis of house dust mite allergy - the value of recombinant allergen-based IgE serology.  
Becker S, Schlederer T, Kramer MF, Haack M, Vrtala S, Resch Y, Lupinek C, Valenta R, Groger M.
Int Arch Allergy Immunol 2016;170(2):132-137

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Allergy and Intolerance Abstracts
Reactions to Rituximab in an Outpatient Infusion Center: A 5-Year Review.
Consistent with previous data, our observations suggest that patients who experience grade 1 reactions to rituximab can be safely rechallenged the same day. A grade 3 or 4 reaction should prompt referral to an allergy specialist for risk assessment before additional rituximab administration. Further research is needed to understand the optimal management of patients with grade 2 reactions

Reactions to Rituximab in an Outpatient Infusion Center: A 5-Year Review.  
Levin AS, Otani IM, Lax T, Hochberg E, Banerji A.
J Allergy Clin Immunol Pract 2016 Aug 3;

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Allergy and Intolerance Abstracts
Early oral exposure to house dust mite allergen through breast milk: a potential risk factor for allergic sensitization and respiratory allergies in children.
Elevated levels of House Dust Mite allergens in breastmilk are associated with an increased risk of atopic sensitization and respiratory allergy in children. This observation highlights a yet unexplored factor that may contribute to allergy development and interfere with prevention of allergy by breastfeeding

Early oral exposure to house dust mite allergen through breast milk: a potential risk factor for allergic sensitization and respiratory allergies in children.  
Baiz N, Macchiaverni P, Tulic MK, Rekima A, nnesi-Maesano I, Verhasselt V.
J Allergy Clin Immunol 2016 Aug 23;

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Allergy and Intolerance Abstracts
Randomized controlled trial of early regular egg intake to prevent egg allergy.
The ideal age to introduce egg into the infant diet has been debated for the past two decades in the context of rising rates of egg allergy. The objective of this study was to determine if regular consumption of egg protein from 4-6 months of age reduces the risk of IgE-mediated egg allergy in infants with hereditary risk, but without eczema. Infants aged 4 to 6 months were randomly allocated to receive daily pasteurized raw whole egg powder (n=407) or a color-matched rice powder (n=413) to 10 months of age. All infants followed an egg-free diet and cooked egg was introduced to both groups at 10 months. The primary outcome was IgE-mediated egg allergy defined by a positive pasteurized raw egg challenge and egg sensitization at 12 months of age. There was no difference between groups in the percentage of infants with IgE-mediated egg allergy (egg 7.0% vs. control 10.3%; adjusted relative risk 0.75; 95% confidence interval 0.48 to 1.17; P=0.20). A higher proportion of participants in the egg group stopped taking the study powder due to a confirmed allergic reaction (25/407, 6.1% compared to 6/413, 1.5%). Egg-specific IgG4 levels were substantially higher in the egg group at 12 months (median 1.22 mgA/L vs. control 0.07 mgA/L; P<0.0001). Therefore, the authors found no evidence that regular egg intake from 4-6 months of age substantially alters the risk of egg allergy by 1 year of age, in infants who are at hereditary risk of allergic disease and had no eczema symptoms at study entry.

Randomized controlled trial of early regular egg intake to prevent egg allergy.  
Palmer DJ, Sullivan TR, Gold MS, Prescott SL, Makrides M.
J Allergy Clin Immunol 2016 Aug 20;

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Index
Allergy and Intolerance Abstracts
Allergenicity and safety of recombinant human C1 esterase inhibitor in patients with allergy to rabbit or cow's milk.
Recombinant human C1 inhibitor (rhC1INH) for on-demand treatment of hereditary angioedema is purified from milk of transgenic rabbits. It contains low amounts (<0.002%) of host-related impurities, which could trigger hypersensitivity reactions in patients with rabbit allergy (RA) and/or cow's milk allergy (CMA). This study is an assessment of allergenicity and safety of rhC1INH in patients with RA and/or CMA. Twenty-six patients with RA and/or CMA were enrolled. Twenty-four had negative SPT and ICT results for rhC1INH, whereas 2 had negative SPT result but positive ICT result to rhC1INH (only the highest concentration). Twenty-two patients with negative SPT and ICT results underwent SC challenge. None developed allergic symptoms. Local treatment-emergent adverse events occurred in 7 patients (32%) after SC challenge. In 5 these were considered drug related. All were mild. None of the patients with negative SPT and ICT results for rhC1INH had allergic symptoms during rhC1INH challenge.

Allergenicity and safety of recombinant human C1 esterase inhibitor in patients with allergy to rabbit or cow's milk.  
van den Elzen MT, van Os-Medendorp H, Rockmann-Helmbach H, van HE, Lebens AF, van DH, Klemans RJ, Bruijnzeel-Koomen CA, Hack CE, Kaufman L, Relan A, Knulst AC.
J Allergy Clin Immunol 2016 Aug;138(2):476-481

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Index
Allergy and Intolerance Abstracts
The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart.
The aim of this study was to explore the natural history of peanut allergy in childhood in two birth cohorts from the same geographical region in the South of England. The FAIR birth cohort was established on the Isle of Wight (UK) between 2001-2002 (n = 969). Children were followed up prospectively, skin prick tested (SPT) to peanut allergens at 1, 2, 3 and 10 years and food challenges performed. The Isle of Wight (IOW) Birth cohort was established in 1989 (n = 1456). SPTs were performed at 1, 2, 4 and 10 years. Peanut allergy was based on positive SPT and a good clinical history. Peanut allergy appears to be stable over the first ten years of life in these cohorts. There was no significant difference in peanut sensitization or clinical peanut allergy between 1989 and 2001.

The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart.  
Venter C, Maslin K, Patil V, Kurukulaaratchy R, Grundy J, Glasbey G, Twiselton R, Dean T, Arshad SH.
Pediatr Allergy Immunol 2016 Jul 19;

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Allergy and Intolerance Abstracts
Egg Sensitisation, Allergy and Component Patterns in African Children with Atopic Dermatitis.
This study aimed to determine the prevalence of, component patterns and predictive values of screening tests in egg allergy in South African children with atopic dermatitis (AD). This was a prospective, observational study in a paediatric university hospital in Cape Town. Children with AD, aged 6 months to 10 years, were recruited randomly. They were assessed for sensitisation and allergy to egg by questionnaire, skin prick tests (SPT), Immuno Solid Phase Allergen Chip (ISAC 103) test, ImmunoCAP component tests to egg and ovomucoid (Gal d 1); and incremental food challenges. 100 participants (59 black Africans and 41 of mixed ethnicity) were enrolled, median age 42 months. There was a high rate of egg sensitisation of 54% and prevalence of confirmed egg allergy of 25%. History and screening laboratory tests overestimated egg allergy significantly. SPT to fresh egg white was significantly more sensitive in diagnosing egg allergy than SPT to the commercial egg white extract, and produced the highest area under the receiver operator characteristics (ROC) curve of all the screening tests in predicting true egg allergy. In those participants sensitised to egg, the component ovomucoid was best at differentiating true egg allergy from tolerance. Commonly used 95% Positive Predictive Values (PPV) for SPT to egg and ImmunoCAP egg white produced low PPV of 57% and 74% respectively in this population overall, with generally poorer predictive values amongst the black Africans than the mixed ethnicity participants. A SPT to fresh egg of 17 mm and ImmunoCAP egg white of 13 kU/L produced the best PPV for egg allergy in this population.

Egg Sensitisation, Allergy and Component Patterns in African Children with Atopic Dermatitis.  
Gray CL, Levin ME, du Toit G.
Pediatr Allergy Immunol 2016 Jul 19;

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Index
Allergy and Intolerance Abstracts
Cross-reactivity in allergic fungal sinusitis. Case report.
A 13-year-old male with nasal obstructive symptoms of three years of evolution. An obstructive mass was identified in the sinuses through physical examination and CT. In endoscopic surgery, the left nostril polyp was identified with the macroscopic appearance of allergic mucin; the polyp was resected. Final histopathological examination indicated Aspergillus. Two weeks after surgery, percutaneous tests showed sensitization to Alternaria, Helminthosporium sativum, and Deramatophagoides farianae with negativity to Aspergillus fumigatus. The absence of significant titers of specific IgE antibodies to Aspergillus fumigatus was the evidence that the hypersensitivity response was triggered by a pathogen other than that isolated in histopathological study, which coupled with positive tests for other fungi may be explained by the cross-reactivity phenomenon in a phenomenon of likely hypersensitivity

Cross-reactivity in allergic fungal sinusitis. Case report. [Spanish]  
Gonzalez-Diaz SN, rias-Cruz A, Rivero-Arias DM, Partida-Ortega AB, Elizondo-Villarreal B, Ibarra-Chavez JA, Ramos-Valencia L, Monge-Ortega OP, ouzet-Sanchez C, Salinas-Diaz MR.
Rev Alerg Mex 2016 Jul;63(3):316-319

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Allergy and Intolerance Abstracts
Men and cypress
"If the cypress tree, a symbol in Mediterrean thought, has always been present, used and appreciated for many centuries on the Mediterrean shores, it must be noted that its use in modern times, while not forgetting that it was part of man's life in days gone by, had deleterious effects on the health of these people. The allergist, being a professional guardian of the environment, must ring the alarm bell and react."

Des hommes et des cyprès / Men and cypress  

Rev Fr Allergol 2016;56(5):416-419

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Index

Allergen-, Food allergy-, Intolerance-related articles

Awareness of allergic enterocolitis among primary-care paediatricians: A web-based pilot survey.  
Comberiati P, Landi M, Martelli A, Piacentini GL, Capristo C, Paiola G, Peroni DG.
Allergol Immunopathol (Madr ) 2016 Aug 3;
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Prevalence of food allergy in infants and pre-schoolers in Brazil.  
Goncalves LC, Guimaraes TC, Silva RM, Cheik MF, de Ramos Napolis AC, Barbosa E Silva, Segundo GR.
Allergol Immunopathol (Madr ) 2016 Aug 2;
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A case of eperisone hydrochloride-induced anaphylaxis: A true type I reaction?  
Miki Y, Washio K, Masaki T, Nakata K, Fukunaga A, Nishigori C.
Allergol Int 2016 Aug 17;

Recent advances in component resolved diagnosis in food allergy.  
Borres MP, Maruyama N, Sato S, Ebisawa M.
Allergol Int 2016 Aug 16;
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Usefulness of antigen-specific IgE probability curves derived from the 3gAllergy assay in diagnosing egg, cow's milk, and wheat allergies.  
Sato S, Ogura K, Takahashi K, Sato Y, Yanagida N, Ebisawa M.
Allergol Int 2016 Aug 11;
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Measuring local immunoglobulin E in the inferior turbinate nasal mucosa in patients with allergic rhinitis.  
Ota Y, Ikemiyagi Y, Sato T, Funakoshi T, Hiruta N, Kitamura M, Bujo H, Suzuki M.
Allergol Int 2016 Aug 8;
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Specific IgE sensitization to honey bee venom and auto-injector adrenaline prescriptions for Japanese beekeepers.  
Hirata H, Tatewaki M, Shiromori S, Ikeno Y, Akutsu I, Sugiyama K, Arima M, Kurasawa K, Fukuda T, Shima D, Fukushima Y.
Allergol Int 2016 Aug 8;

Acetaminophen anaphylaxis diagnosed by skin prick test.  
Numata T, Fukushi R, Ito T, Tsuboi R, Harada K.
Allergol Int 2016 Jul 23;

Anaphylaxis to Japanese butterbur scapes.  
Kataoka Y, Tamagawa-Mineoka R, Masuda K, Katoh N.
Allergol Int 2016 Jul 19;

Delayed hypersensitivity reaction to loperamide: An intriguing case report with positive challenge test.  
Nahas O, Alary V, Chiriac AM, Philibert C, Demoly P, Hillaire-Buys D.
Allergol Int 2016 Jun 27;

Allergy to fish collagen: Thermostability of collagen and IgE reactivity of patients' sera with extracts of 11 species of bony and cartilaginous fish.  
Kobayashi Y, Kuriyama T, Nakagawara R, Aihara M, Hamada-Sato N.
Allergol Int 2016 May 25;
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Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS): 11 years retrospective study in Thailand.  
Hiransuthikul A, Rattananupong T, Klaewsongkram J, Rerknimitr P, Pongprutthipan M, Ruxrungtham K.
Allergol Int 2016 Apr 28;

Anaphylaxis provoked by ingestion of hydrolyzed fish collagen probably induced by epicutaneous sensitization.  
Wataru Fujimoto, Mikiko Fukuda, Tomoharu Yokooji, Takahiro Yamamoto, Akira Tanaka, Hiroaki Matsuo.
Allergol Int 2016 July 25;
Abstract

A. fumigatus components distinguish IgE but not IgG4 profiles between fungal sensitization and ABPA.  
Vitte J, Romain T, Carsin A, Gouitaa M, Stremler-Le BN, Baravalle-Einaudi M, Cleach I, Reynaud-Gaubert M, Dubus JC, Mege JL.
Allergy 2016 Aug 19;
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Abstracts from the European Academy of Allergy and Clinical Immunology Congress, 11-15 June 2016, Vienna, Austria.  

Allergy 2016 Aug;71 Suppl 1023-633

Application of recombinant antigen 5 allergens from seven allergy-relevant Hymenoptera species in diagnostics.  
Schiener M, Eberlein B, Moreno-Aguilar C, Pietsch G, Serrano P, McIntyre M, Schwarze L, Russkamp D, Biedermann T, Spillner E, Darsow U, Ollert M, Schmidt-Weber CB, Blank S.
Allergy 2016 Aug 6;
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Transcriptomic/proteomic identification of allergens in the mite Tyrophagus putrescentiae.  
Cui Y, Yu L, Teng F, Zhang C, Wang N, Yang L, Zhou Y.
Allergy 2016 Aug 6;
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Antibiotic prescription and food allergy in young children.  
Love BL, Mann JR, Hardin JW, Lu ZK, Cox C, Amrol DJ.
Allergy Asthma Clin Immunol 2016;1241
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Prevalence and clinical features of adverse food reactions in Portuguese adults.  
Lozoya-Ibanez C, Morgado-Nunes S, Rodrigues A, Lobo C, Taborda-Barata L.
Allergy Asthma Clin Immunol 2016;1236
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Reproducibility of serum IgE, Ara h2 skin prick testing and fraction of exhaled nitric oxide for predicting clinical peanut allergy in children.  
Percival E, Bhatia R, Preece K, McElduff P, McEvoy M, Collison A, Mattes J.
Allergy Asthma Clin Immunol 2016;1235
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Clinical and immuno-proteomic approach on Lantana camara pollen allergy-a major health hazard.  
Ghosal K, Saha B, Gupta BS.
Allergy Asthma Clin Immunol 2016;1233
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Retrospective analysis on the agreement between skin prick test and serum food specific IgE antibody results in adults with suspected food allergy.  
Ling L, Ospina MB, Sideri K, Vliagoftis H.
Allergy Asthma Clin Immunol 2016;1230
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High sensitization to house-dust mites in patients with allergic rhinitis in the eastern Black Sea region of Turkey: A retrospective study.  
Coskun ZO, Erdivanli OC, Kazikdas KC, Terzi S, Sahin U, Ozgur A, Demirci M, Dursun E, Cingi C.
Am J Rhinol Allergy 2016 Jul 1;
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New allergen sensitization might be associated with increased body mass index in children.  
Lee EJ, Kim JH, Lee KH, Hong SC, Lee HS, Kang JW.
Am J Rhinol Allergy 2016 Jul;30(4):124-127
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Managing anaphylaxis in the office setting.  
Cingi C, Wallace D, Bayar MN, Ebisawa M, Castells M, Sahin E, Altintoprak N.
Am J Rhinol Allergy 2016 Jul;30(4):118-123
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When voluntary paracetamol overdose requires a drug challenge.  
Carsin A, Vitte J, Demoly P, Dubus JC.
Ann Allergy Asthma Immunol 2016 Aug 23;

Effect of ivermectin on allergy-type manifestations in occult strongyloidiasis.  
Rampur L, Jariwala SP, Hudes G, Rosenstreich DL, de VG.
Ann Allergy Asthma Immunol 2016 Aug 23;
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Association of tree nut and coconut sensitization.  
Polk BI, Dinakarpandian D, Nanda M, Barnes C, Dinakar C.
Ann Allergy Asthma Immunol 2016 Aug 23;
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Effect of aeroallergen sensitization on asthma control in African American teens with persistent asthma.  
Burbank AJ, Grabich SC, Todorich K, Frye M, Loughlin C, Duncan K, Robinette C, Mills K, Peden DB, az-Sanchez D, Hernandez ML.
Ann Allergy Asthma Immunol 2016 Aug 23;

Pruritus from allergy skin tests in children: Comparing remedies.  
Stewart S, Boscher J, Hossain J, McGeady SJ, Yousef E.
Ann Allergy Asthma Immunol 2016 Aug 10;

The histamine skin prick test: An analysis of the method for use in clinical trials.  
Brevard J, Elder MA, Berman G, Tan Y, Volfson D, Ogden A, Evans B, Bednar MM.
Ann Allergy Asthma Immunol 2016 Aug 9;

Allergic contact dermatitis to balsam of Peru.  
Nanda A, Wasan A.
Ann Allergy Asthma Immunol 2016 Aug;117(2):208-209

Hypersensitivity and immunologic reactions to biologics: opportunities for the allergist.  
Khan DA.
Ann Allergy Asthma Immunol 2016 Aug;117(2):115-120
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Paracetamol-induced fixed drug eruption in a patient with recurrent fever and rash.  
Misirlioglu ED, Akman AO, Vezir E, Basaran O, Cakar N, Kocabas CN.
Ann Allergy Asthma Immunol 2016 Aug;117(2):210-211

A report on 2011 nationwide survey of immediate type food allergies in Japan (supported by a grant from 'consumer affairs agency, government of Japan'. [Japanese]  
Imai T, Sugizaki C, Ebisawa M.
Arerugi 2016 Jul;65(7):942-946

A case of anaphylaxis in the pediatric patient with milk allergy due to traces of milk protein in the lactose used as an excipient of inavir inhalation. [Japanese]  
Morikawa M, Kanemitsu Y, Tsukamoto H, Morikawa A, Tomioka Y.
Arerugi 2016 May;65(3):200-205
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Methods of ingestion in oral food challenge tests using whole-egg powder. [Japanese]  
Yanagida N, Sato S, Ebisawa M.
Arerugi 2016 May;65(3):193-199
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Allergens. [Japanese]  
Takai T.
Arerugi 2016 May;65(3):159-165

Marking nut anaphylaxis.  
Fok JS, Kral AC, Hayball J, Smith WB.
Asia Pac Allergy 2016 Jul;6(3):192-194
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Delayed diagnosis of allergic bronchopulmonary aspergillosis due to absence of asthmatic symptoms.  
Kim Y, Lee HY, Gu KM, Lee JY, Yoon SW, Park TY, Choi JC, Kim JY, Park IW, Shin JW, Choi BW, Jung JW.
Asia Pac Allergy 2016 Jul;6(3):187-191
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Aeroallergen sensitization and allergic disease phenotypes in Asia.  
Tham EH, Lee AJ, Bever HV.
Asian Pac J Allergy Immunol 2016 Aug 16;
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Age of Resolution from IgE-Mediated Wheat Allergy.  
Siripipattanamongkol N, Vichyanond P, Jirapongsananuruk O, Veskitkul J, Visitsunthorn N, Pacharn P.
Asian Pac J Allergy Immunol 2016 Aug 16;
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Genetic Polymorphisms and Allergenicity of Blo t 5 in a House Dust Mite Allergic Filipino Population.  
Medina LR, Malainual N, Ramos JD.
Asian Pac J Allergy Immunol 2016 Aug 16;
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Species and quantity of airborne pollens in Shanghai as monitored by gravitational and volumetric methods.  
Sun L, Xu Y, Wang Y, Lou Y, Xu Y, Guo Y.
Asian Pac J Allergy Immunol 2016 Aug 16;
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The Etiology and Clinical Features of Anaphylaxis in a developing country: A nationwide survey in Turkey.  
Civelek E, Erkocoglu M, Akan A, Ozcan C, Kaya A, Vezir E, Ginis T, Toyran M, Tokac M, Kocabas CN.
Asian Pac J Allergy Immunol 2016 Aug 16;
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Skin testing with beta-lactam Antibiotics for Diagnosis of beta-lactam Hypersensitivity in Children.  
Manuyakorn W, Singvijarn P, Benjaponpitak S, Kamchaisatian W, Rerkpattanapipat T, Sasisakulporn C, Jotikasthira W.
Asian Pac J Allergy Immunol 2016 Aug 16;
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Cross-reactive antibodies against H7N9 and H5N1 avian influenza viruses in Thai population.  
Jiang L, Changsom D, Lerdsamran H, Masamae W, Jongkaewwattana A, Iamsirithaworn S, Oota S, Louisirirotchanakul S, Auewarakul P, Puthavathana P.
Asian Pac J Allergy Immunol 2016 Aug 16;
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Effects of maternal dietary egg intake during early lactation on human milk ovalbumin concentration: a randomized controlled trial.  
Metcalfe JR, Marsh JA, D'Vaz N, Geddes DT, Lai CT, Prescott SL, Palmer DJ.
Clin Exp Allergy 2016 Aug 26;
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Subgroup differences in the associations between dog exposure during the first year of life and early life allergic outcomes.  
Wegienka G, Havstad S, Kim H, Zoratti E, Ownby D, Woodcroft KJ, Johnson CC.
Clin Exp Allergy 2016 Aug 26;
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Experimental food allergy to peanut enhances the immune response to house dust mite in the airways of mice.  
Utsch L, Logiantara A, van RR, van Rijt LS.
Clin Exp Allergy 2016 Aug 17;
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Metabolomic analysis identifies potential diagnostic biomarkers for aspirin-exacerbated respiratory disease.  
Ban GY, Cho K, Kim SH, Yoon MK, Kim JH, Lee HY, Shin Y, Ye YM, Cho JY, Park HS.
Clin Exp Allergy 2016 Aug 17;
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The conformational IgE epitope profile of soybean allergen Gly m 4.  
Husslik F, Nurnberg J, Seutter von LC, Mews T, Ballmer-Weber BK, Kleine-Tebbe J, Treudler R, Simon JC, Randow S, Volker E, Reuter A, Rosch P, Vieths S, Holzhauser T, Schiller D.
Clin Exp Allergy 2016 Aug 17;
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Dust mite allergen, glutathione S-transferase, induces T cell immunoglobulin mucin domain-4 in dendritic cells to facilitate initiation of airway allergy.  
Mo LH, Yang LT, Zeng L, Xu LZ, Zhang HP, Li LJ, Liu JQ, Xiao XJ, Zheng PY, Liu ZG, Yang PC.
Clin Exp Allergy 2016 Aug 17;
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sIgE Ana o 1, 2 and 3 accurately distinguish tolerant from allergic children sensitised to cashew nuts.  
van der Valk JP, Gerth van Wijk R, Vergouwe Y, Steyerberg EW, Reitsma M, Wichers HJ, Savelkoul HF, Vlieg-Boerstra B, de Groot H, Dubois AE7, de Jong NW.
Clin Exp Allergy 2016 Aug 11;
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Conformational IgE epitopes of peanut allergens Ara h 2 and Ara h 6.  
Chen X, Negi SS, Liao S, Gao V, Braun W, Dreskin SC.
Clin Exp Allergy 2016 Aug;46(8):1120-1128
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Drug induced exfoliative dermatitis: state of the art.  
Yacoub MR, Berti A, Campochiaro C, Tombetti E, Ramirez GA, Nico A, Di LE, Fantini P, Sabbadini MG, Nettis E, Colombo G.
Clin Mol Allergy 2016;149
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Pilot study: assessing the clinical diagnosis of allergy in atopic children using a microarray assay in addition to skin prick testing and serum specific IgE.  
Foong RX, Roberts G, Fox AT, du Toit G.
Clin Mol Allergy 2016;148
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Hypersensitivity pneumonitis due to metalworking fluid aerosols.  
Burge PS.
Curr Allergy Asthma Rep 2016 Aug;16(8):59
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Impact of changed legislation on skin tests: the present and future.  
Klimek L, Hoffmann HJ, Kugler A, Muraro A, Hellings PW.
Curr Opin Allergy Clin Immunol 2016 Aug 17;
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Allergic manifestations of contact lens wearing.  
Solomon A.
Curr Opin Allergy Clin Immunol 2016 Aug 11;
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Scombroid syndrome: it seems to be fish allergy but... it isn't.  
Ridolo E, Martignago I, Senna G, Ricci G.
Curr Opin Allergy Clin Immunol 2016 Jul 27;
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Should patients with pollen fruit syndrome be prescribed an automatic epinephrine injector?  
Katelaris CH.
Curr Opin Allergy Clin Immunol 2016 Aug;16(4):370-374
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Advances in hypersensitivity drug reactions.  
Blanca M, Thong BY.
Curr Opin Allergy Clin Immunol 2016 Aug;16(4):297-299

Doctor, when should I feed solid foods to my infant?  
Fiocchi A, Dahdah L, Bahna SL, Mazzina O, Assa'ad A.
Curr Opin Allergy Clin Immunol 2016 Aug;16(4):404-411
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Large local reactions to insect envenomation.  
Carlson J, Golden DB.
Curr Opin Allergy Clin Immunol 2016 Aug;16(4):366-369
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Hypersensitivity reactions to heparins.  
Gonzalez-Delgado P, Fernandez J.
Curr Opin Allergy Clin Immunol 2016 Aug;16(4):315-322
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Understanding the mechanisms in accelerated drug reactions.  
Torres MJ, Salas M, Ariza A, Fernandez TD.
Curr Opin Allergy Clin Immunol 2016 Aug;16(4):308-314
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Epinephrine auto-injector needle length: what is the ideal length?  
Song TT, Lieberman P.
Curr Opin Allergy Clin Immunol 2016 Aug;16(4):361-365
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Development of nanostructures in the diagnosis of drug hypersensitivity reactions.  
Mayorga C, Perez-Inestrosa E, Molina N, Montanez MI.
Curr Opin Allergy Clin Immunol 2016 Aug;16(4):300-307
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Update on biphasic anaphylaxis.  
Lee S, Sadosty AT, Campbell RL.
Curr Opin Allergy Clin Immunol 2016 Aug;16(4):346-351
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Real-life study for the diagnosis of house dust mite allergy - the value of recombinant allergen-based IgE serology.  
Becker S, Schlederer T, Kramer MF, Haack M, Vrtala S, Resch Y, Lupinek C, Valenta R, Groger M.
Int Arch Allergy Immunol 2016;170(2):132-137
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Drug Reaction, Eosinophilia, and Systemic Symptoms (DRESS) syndrome associated with allopurinol leading to acute necrotizing eosinophilic myocarditis and death due to papillary muscle rupture.  
Menter T, Tzankov A.
J Allergy Clin Immunol Pract 2016 Aug 11;

Anaphylaxis to intravenous gentamicin with suspected sensitization through gentamicin-loaded bone cement.  
Christiansen IS, Pedersen P, Kroigaard M, Mosbech H, Garvey LH.
J Allergy Clin Immunol Pract 2016 Aug 11;

Rate of food introduction after a negative oral food challenge in the pediatric population.  
Gau J, Wang J.
J Allergy Clin Immunol Pract 2016 Aug 24;

Reactions to Rituximab in an Outpatient Infusion Center: A 5-Year Review.  
Levin AS, Otani IM, Lax T, Hochberg E, Banerji A.
J Allergy Clin Immunol Pract 2016 Aug 3;
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Associations between outdoor fungal spores and childhood and adolescent asthma hospitalisations.  
Tham R, Vicendese D, Dharmage S, Hyndman RJ, Newbigin E, Lewis E, O'Sullivan M, Lowe AJ, Taylor P, Bardin P, Tang ML, Abramson MJ, Erbas B.
J Allergy Clin Immunol 2016 Aug 11;
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LEAPing ahead with early allergen consumption.  
Venter C, Groetch M.
J Allergy Clin Immunol 2016 Aug 23;

Early oral exposure to house dust mite allergen through breast milk: a potential risk factor for allergic sensitization and respiratory allergies in children.  
Baiz N, Macchiaverni P, Tulic MK, Rekima A, nnesi-Maesano I, Verhasselt V.
J Allergy Clin Immunol 2016 Aug 23;
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Role of IgG4 in IgE-mediated allergic responses.  
van d, Akdis M.
J Allergy Clin Immunol 2016 Aug 23;

Randomized controlled trial of early regular egg intake to prevent egg allergy.  
Palmer DJ, Sullivan TR, Gold MS, Prescott SL, Makrides M.
J Allergy Clin Immunol 2016 Aug 20;
Click to view abstract

The IgE and basophil response to Ara h 2 and Ara h 6 are good predictors of peanut allergy in children.  
van Erp FC, Knol EF, Pontoppidan B, Meijer Y, van der Ent CK, Knulst AC.
J Allergy Clin Immunol 2016 Aug 8;
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Common peptide epitopes induce cross-reactivity in hypersensitivity pneumonitis serodiagnosis.  
Millon L, Rognon B, Valot B, Barrera C, Bellanger AP, Roussel S, Dalphin JD, Monod M, Reboux G.
J Allergy Clin Immunol 2016 Aug 3;
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Allergenicity and safety of recombinant human C1 esterase inhibitor in patients with allergy to rabbit or cow's milk.  
van den Elzen MT, van Os-Medendorp H, Rockmann-Helmbach H, van HE, Lebens AF, van DH, Klemans RJ, Bruijnzeel-Koomen CA, Hack CE, Kaufman L, Relan A, Knulst AC.
J Allergy Clin Immunol 2016 Aug;138(2):476-481
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Relationship between specific IgE to egg components and natural history of egg allergy in Danish children.  
Gradman J, Mortz CG, Eller E, Bindslev-Jensen C.
Pediatr Allergy Immunol 2016 Aug 27;
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Drug-Induced Enterocolitis Syndrome (DIES) by Amoxicilin.  
Infante S, Zapatero L.
Pediatr Allergy Immunol 2016 Aug 20;
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Oral food challenge with a mixture of 'at risk' foods in children with FPIES.  
Sopo SM, Bersani G, Cerchiara G, Monaco S.
Pediatr Allergy Immunol 2016 Aug 10;
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Skin prick test and development of tolerance in egg allergy.  
Caffarelli C, Rico S, Varini M, Povesi-Dascola C, Mastrorilli C.
Pediatr Allergy Immunol 2016 Aug 10;
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Specific Oral Tolerance Induction in Childhood.  
Peters RL, Dang TD, Allen KJ.
Pediatr Allergy Immunol 2016 Aug 6;
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Priapism as a new symptom of anaphylaxis in a prepubescent child.  
Castilla-Hernandez E, Garriga-Baraut T.
Pediatr Allergy Immunol 2016 Aug 6;
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No difference in health-related quality of life, after a food challenge with cashew nut in children participating in a clinical trial.  
van d, Gerth van WR, Flokstra-de Blok BM, van d, de GH, Wichers HJ, Dubois AE, de Jong NW.
Pediatr Allergy Immunol 2016 Aug 6;
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The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart.  
Venter C, Maslin K, Patil V, Kurukulaaratchy R, Grundy J, Glasbey G, Twiselton R, Dean T, Arshad SH.
Pediatr Allergy Immunol 2016 Jul 19;
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Egg Sensitisation, Allergy and Component Patterns in African Children with Atopic Dermatitis.  
Gray CL, Levin ME, du Toit G.
Pediatr Allergy Immunol 2016 Jul 19;
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EAACI Molecular Allergology User's Guide.  
Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S, Aalberse RC, Agache I, Asero R, Ballmer-Weber B, Barber D, Beyer K, Biedermann T, Bilo MB, Blank S, Bohle B, Bo.
Pediatr Allergy Immunol 2016 May;27 Suppl 231-250
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Cross-reactivity in allergic fungal sinusitis. Case report. [Spanish]  
Gonzalez-Diaz SN, rias-Cruz A, Rivero-Arias DM, Partida-Ortega AB, Elizondo-Villarreal B, Ibarra-Chavez JA, Ramos-Valencia L, Monge-Ortega OP, ouzet-Sanchez C, Salinas-Diaz MR.
Rev Alerg Mex 2016 Jul;63(3):316-319
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In memoriam : Madame le Professeur Moneret-Vautrin  
É. Beaudouin, A. Sabbah
Rev Fr Allergol 2016;56(5):399-400
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The general practitioner facing the management of the "drug allergy" light on the current practice in the Rhône-Alpes region and prospects for improvement [French]  
V.-A. Huynh, E. Lungoci, A. Nosbaum, F. Hacard, F. Subtil, J.-F. Nicolas, F. Bérard
Rev Fr Allergol 2016;56(5):401-406
Click to view abstract Click to view abstract

Des hommes et des cyprès / Men and cypress  

Rev Fr Allergol 2016;56(5):416-419
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Allergie à la pêche avec taux d’IgE spécifiques pêche et allergènes majeurs négatifs ou faiblement positifs  
Tenenbaum J, Leoni MC , Demoly MP, Bourrain JL, Demoly P, Chiriac AM.
Rev Fr Allergol 2016;56(5):441-445
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Eosinophilic esophagitis: published evidences for disease subtypes, indications for patient subpopulations, and how to translate patient observations to murine experimental models.  
Mudde AC, Lexmond WS, Blumberg RS, Nurko S, Fiebiger E.
World Allergy Organ J 2016;923
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