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 Allergy Advisor Digest - March 2015
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Read Allergen skin prick test should be adjusted by the histamine reactivity.
Read Evaluation of methods for the estimation of threshold concentrations by the skin prick test.
Read Identification of rice proteins recognized by the IgE antibodies of patients with food allergies.
Read Overview of plant chitinases identified as food allergens.
Read The Citrus clementina putative allergens: from proteomic analysis to structural features.
Read Indoor determinants of dustborne allergens in Mexican homes.
Read IgE Reactivity of the Dog Lipocalin Allergen Can f 4 and the Development of a Sandwich ELISA
Read Seven steps to the diagnosis of NSAIDs hypersensitivity: how to apply a new classification in real practice?
Read Japanese Cedar (Cryptomeria japonica) Pollinosis in Jeju, Korea: Is It Increasing?
Read Early-life mold and tree sensitivity is associated with allergic eosinophilic rhinitis at 4 years of age.
Read A case of anaphylaxis caused by enokitake (flammulina velutipes) ingestion.
Read Soy in wheat--contamination levels and food allergy risk assessment.
Read Hypersensitivity to mosquito bite manifested as Skeeter syndrome.

Abstracts shared in March 2015 Advisor Digest Newsletter

Read IgE sensitization to lupine in bakers - cross-reactivity or co-sensitization to wheat flour?
Read Molecular diagnosis of shrimp allergy: efficiency of several allergens to predict clinical reactivity.
Read Identification of an abundant 56 kDa rice protein implicated in food allergy as granule-bound starch synthase.
Read Accuracy of ELISA detection methods for gluten and reference materials: a realistic assessment.
Read Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey.
Read High prevalence of gluten sensitivity in a cohort of patients with undifferentiated connective tissue disease.
Read An IgE-mediated allergic reaction caused by mulberry fruit.
Read Butter tolerance in children allergic to cow's milk.
Read Allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides.
Read The significance of allergic contact urticaria to milk in children with cow's milk allergy.
Read The IgE response to Ascaris molecular components is associated with clinical indicators of asthma severity

Allergy and Intolerance Abstracts
Allergen skin prick test should be adjusted by the histamine reactivity.
Skin prick test results are mostly reported as mean wheal diameter obtained with one concentration of allergen. Differences in technique between personnel causes variation in wheal size. The research question was whether the influence of differences in skin prick test technique among assistants and centers can be reduced by relating the allergen wheal response to that of histamine. The study concludes that to reduce the influence of differences in test technique among assistants and centers responses to allergen-induced skin prick tests should be compared to that of histamine.

Allergen skin prick test should be adjusted by the histamine reactivity.  
Dreborg S.
Int Arch Allergy Immunol 2015 Mar 3;166(1):77-80

Click to view abstract

Index
Allergy and Intolerance Abstracts
Evaluation of methods for the estimation of threshold concentrations by the skin prick test.
The aim of this study was to present and validate simple methods for estimation of the skin sensitivity given as the concentration inducing a wheal of the same size as that with the positive reference, 10 mg/ml of histamine HCl, in the same patient.

The study concludes that the validated methods reduce the error of differences in testing techniques and make it possible to report skin sensitivity at threshold concentrations. A simple method to be used in clinical practice and a method suitable to describe changes in skin reactivity over time or during treatment are proposed.

Evaluation of methods for the estimation of threshold concentrations by the skin prick test.  
Dreborg S, Holgersson M.
Int Arch Allergy Immunol 2015 Mar 3;166(1):71-76

Click to view abstract

Index
Allergy and Intolerance Abstracts
Identification of rice proteins recognized by the IgE antibodies of patients with food allergies.
Similarity among food allergens is a great problem affecting the specificity of diagnosis and treatment of allergic patients. We have observed that 80% of patients with food (including wheat) and pollen allergies have increased IgE antibodies against rice proteins. By immunoblotting, we documented that boiling decreased solubility and IgE reactivity of PBS-extracted rice and wheat proteins, yet in SDS extracts this reactivity was only slightly changed. The sera of patients highly positive on the IgE immunoblot and positive in basophil activation and skin prick test with boiled rice components were used for characterizing the IgE-binding proteins. We identified 22 rice SDS soluble proteins. Six of them were new thermostable potential rice allergens: glutelin C precursor, granule-bound starch synthase 1 protein, disulfide isomerase-like 1-1 protein, hypothetical protein OsI_13867, putative acid phosphatase precursor 1, and a protein encoded by locus Os02g0453600. All of the identified rice proteins differed from known wheat allergens, except proteins belonging to the alpha-amylase/trypsin inhibitor family. Furthermore, we would suggest that in patients with high IgE reactivity to wheat and rice components, the IgE immunoblot and skin prick test with boiled rice proteins could be beneficial before diet recommendation.

Identification of rice proteins recognized by the IgE antibodies of patients with food allergies.  
Golias J, Humlova Z, Halada P, Habova V, Janatkova I, Tuckova L.
J Agric Food Chem 2013 Sep 18;61(37):8851-8860

Index
Allergy and Intolerance Abstracts
Overview of plant chitinases identified as food allergens.
In plants, there are at least five structural classes of chitinases plus a number of chitinase-related polypeptides. Their allergenicity has been mostly investigated for chitinases of class I, due to both their higher prevalence among plant chitinases and by the high structural similarity between their substrate-binding domain and hevein, a well-known allergen present in the latex of rubber trees. Even if allergenic molecules have been identified for at least three other classes of plant chitinases, the involvement of the different structural motifs in the allergenicity of molecules has been disregarded so far. In this review, we provide a structurally based catalog of plant chitinases investigated for allergenicity, which could be a useful base for further studies aimed at better clarifying the structure-allergenicity relationships for this protein family.

Overview of plant chitinases identified as food allergens.  
Volpicella M, Leoni C, Fanizza I, Placido A, Pastorello EA, Ceci LR.
J Agric Food Chem 2014 Jun 25;62(25):5734-5742

Index
Allergy and Intolerance Abstracts
The Citrus clementina putative allergens: from proteomic analysis to structural features.
Several allergens have been identified and characterized in the genus Citrus, which belongs to the germin-like proteins (GPLs), profilins, and non-specific lipid transfer proteins (nsLTPs). In this work putative allergens of Citrus clementina and their expression level in the fruit peel was studied. Fifteen new sequences belonging to GLPs (Cit cl 1), and two more belonging to nsLTPs (Cit cl 3) were found. No other new sequences were found as regards profilins (Cit cl 2). From fruit peel, Cit cl 1 had a higher expression level than Cit cl 2 and Cit cl 3. Cit cl 1 homologous protein structure had high correspondence with the oxalate oxidase protein in barley.

The Citrus clementina putative allergens: from proteomic analysis to structural features.  
Serra IA, Bernardo L, Spadafora A, Faccioli P, Canton C, Mazzuca S.
J Agric Food Chem 2013 Sep 18;61(37):8949-8958

Index
Allergy and Intolerance Abstracts
Indoor determinants of dustborne allergens in Mexican homes.
This study evaluates the main environmental and household predictors of high prenatal allergen levels and multiple allergen exposures in a birth cohort from Mexico City. A cross-sectional study was conducted of 1094 infants. Dust samples was collected in a subset of 264 homes. Der p 1, Der f 1, dust mite group 2, Fel d 1, Can f 1, Rat n 1, Mus m 1, and Bla g 2 concentrations in dust samples were measured. Eighty-five percent of homes had at least one allergen in dust over the detection limit, 52.1% had high exposure (four or more allergens above detectable limits), and 11.7% of homes had detectable levels for more than eight allergens. Der p 1, Der p 2, Mus m 1, and Fel d 1 were the most frequent allergens detected.

Indoor determinants of dustborne allergens in Mexican homes.  
Hernandez-Cadena L, Zeldin DC, Barraza-Villarreal A, Sever ML, Sly PD, London SJ, Escamilla-Nunez MC, Romieu I.
Allergy Asthma Proc 2015 Mar;36(2):130-137

Click to view abstract

Index
Allergy and Intolerance Abstracts
IgE Reactivity of the Dog Lipocalin Allergen Can f 4 and the Development of a Sandwich ELISA
Divergent results on the IgE reactivity of dog-allergic subjects to Can f 4 have been reported. The aim of this study was to evaluate the significance of Can f 4 in dog allergy and to develop an immunochemical method for measuring Can f 4 content in environmental samples. The natural dog allergen Can f 4 from a dog dander extract was purified and a recombinant form generated. Sixty-three dog-allergic patients and 12 nonallergic control subjects were recruited in the study. Eighty-one percent of the dog-allergic patients showed a positive result to the immunoaffinity-purified natural Can f 4 in IgE ELISA, but only 46% in IgE immunoblotting. Respective results with the recombinant Can f 4 variant were 54% and 49%. SPT results reflected those obtained in ELISA and immunoblotting. The overall IgE reactivity of the immunoaffinity-purified natural Can f 4 was found to depend strongly on the integrity of the allergen's conformation. A sandwich ELISA based on monoclonal antibodies was found to be functional for measuring Can f 4 in environmental samples. Can f 4 is a major allergen of dog together with Can f 1 and Can f 5. In combination with other dog allergens, it improves the reliability of allergy tests in dog allergy.

IgE Reactivity of the Dog Lipocalin Allergen Can f 4 and the Development of a Sandwich ELISA for Its Quantification.  
Rytkonen-Nissinen M, Saarelainen S, Randell J, Hayrinen J, Kalkkinen N, Virtanen T.
Allergy Asthma Immunol Res 2015 Mar 5;

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Index
Allergy and Intolerance Abstracts
Seven steps to the diagnosis of NSAIDs hypersensitivity: how to apply a new classification in real practice?
Frequent use of non-steroidal anti-inflammatory drugs (NSAIDs) has been paralleled by increasing occurrence of adverse reactions, which vary from mild local skin rashes or gastric irritation to severe, generalized symptoms and even life-threatening anaphylaxis. NSAID-induced hypersensitivity reactions may involve both immunological and non-immunological mechanisms and should be differentiated from type A adverse reactions. Clinical diagnosis and effective management of a hypersensitive patient cannot be achieved without identifying the underlying mechanism. In this review, we discuss the current classification of NSAID-induced adverse reactions and propose a practical diagnostic algorithm that involves 7 steps leading to the determination of the type of NSAID-induced hypersensitivity and allows for proper patient management

Seven steps to the diagnosis of NSAIDs hypersensitivity: how to apply a new classification in real practice?  
Kowalski ML, Makowska JS.
Allergy Asthma Immunol Res 2015 Mar 5;

Click to view abstract

Index
Allergy and Intolerance Abstracts
Japanese Cedar (Cryptomeria japonica) Pollinosis in Jeju, Korea: Is It Increasing?
Jeju is an island in South Korea located in a temperate climate zone. Japanese cedar tree (JC) has become the dominant tree species while used widely to provide a windbreak for the tangerine orchard industry. An increase in pollen counts precedes atopic sensitization to pollen and pollinosis, but JC pollinosis in Jeju has never been studied. This study investigated JC pollen counts, sensitization to JC pollen, and JC pollinosis. Participants were recruited among schoolchildren residing in Jeju City, the northern region (NR) and Seogwipo City, the southern region (SR) of the island. Among 1,225 schoolchildren (49.6% boys, median age 13 years), 566 (46.2%) were atopic. The rate of sensitization to Dermatophagoides pteronyssinus (35.8%) was highest, followed by D. farinae (26.2%), and JC (17.6%). In SR, 156 children (23.8%) were sensitized to JC pollen; this rate was significantly higher than that in NR (59 children, 10.4%, P < 0.001). A significant increment in the sensitization rate to JC pollen with increasing school level was observed only in SR. JC pollen season in SR started earlier and lasted longer than that in NR. JC pollen season in Jeju was defined as extending from late January to mid-April. The prevalence of JC pollinosis was estimated to be 8.5%. The prevalence differed significantly between NR and SR (5.3% vs 11.3%, P < 0.001), mainly due to the difference in sensitization rates.

Japanese Cedar (Cryptomeria japonica) Pollinosis in Jeju, Korea: Is It Increasing?  
Lee J, Lee KH, Lee HS, Hong SC, Kim JH.
Allergy Asthma Immunol Res 2015 Mar 5;

Click to view abstract

Index
Allergy and Intolerance Abstracts
Early-life mold and tree sensitivity is associated with allergic eosinophilic rhinitis at 4 years of age.
The objective of this study was to identify predictors of allergic eosinophilic rhinitis (AER) in early childhood in children at higher risk for chronic allergic respiratory disorders. In the Cincinnati Childhood Allergy and Air Pollution Study, infants born to aeroallergen-sensitized and symptomatic parents were examined and underwent skin prick testing (SPT) annually to 15 aeroallergens from 1 to 4 years of age. At 4 years, 487 children completed rhinitis health histories, SPT, and nasal sampling. Ninety-nine children (22.8%) had AR. Thirty-eight children had AER (8.8% of total sample and 38.4% of AR sample, respectively). At 3 years, for every 1-mm(2) increase in Penicillium species and maple, wheal area significantly increased the risk of AER at 4 years of age.

Early-life mold and tree sensitivity is associated with allergic eosinophilic rhinitis at 4 years of age.  
Codispoti CD, Bernstein DI, Levin L, Reponen T, Ryan PH, Biagini Myers JM, Villareal M, Burkle J, Lummus Z, Lockey JE, Khurana Hershey GK, LeMasters GK.
Ann Allergy Asthma Immunol 2015 Mar;114(3):193-198

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Index
Allergy and Intolerance Abstracts
A case of anaphylaxis caused by enokitake (flammulina velutipes) ingestion.
Enokitake (Flammulina velutipes, winter mushroom) is a common edible mushroom in Japan. A first case of anaphylaxis after enokitake ingestion is described. The patient was a seventeen-year-old woman who had had no episodes of food allergy and experienced anaphylaxis after the ingestion of sukiyaki (beef, pork, tofu, vegetables, enokitake, etc.). She had previously eaten sukiyaki (the same ingredients) without any symptoms. Skin prick to prick test was positive. Oral food challenge was positive. Three enokitake protein bands (18 kDa, 39 kDa, 50 kDa) reacted specifically with the patient's IgE.

A case of anaphylaxis caused by enokitake (flammulina velutipes) ingestion. [Japanese]  
Otsuji K, Ohara K, Nakamura M, Amazumi R, Higa C, Kakazu K, Kondo Y.
Arerugi 2015 Feb;64(1):63-67

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Index
Allergy and Intolerance Abstracts
Soy in wheat--contamination levels and food allergy risk assessment.
Clinical reports of allergic reactions to undeclared soy in wheat-based products do not exist suggesting that a rather low degree of risk is posed by wheat-based products that are comingled with soy. Detectable soybean residues (>2.5 ppm soy flour) were found in 62.8% of commercially available wheat flours at concentrations of 3-443 ppm soy flour (1.6-236 ppm soy protein). Conservative probabilistic risk assessments predict a risk of allergic reaction among the most sensitive soy-allergic individuals of 2.8+/-2.0 per 1000 soy-allergic user eating occasions of foods containing wheat flour. However, the predicted reactions occur at exposure levels below the lowest eliciting dose observed to provoke objective reactions in clinical oral soy challenges. Given this low level of predicted risk and the lack of evidence for allergic reactions among soy-allergic consumers to wheat-based products, the avoidance of wheat-based products by soy-allergic consumers does not appear to be necessary.

Soy in wheat--contamination levels and food allergy risk assessment.  
Remington BC, Taylor SL, Marx DB, Petersen BJ, Baumert JL.
Food Chem Toxicol 2013 Dec;62485-491

Index
Allergy and Intolerance Abstracts
Hypersensitivity to mosquito bite manifested as Skeeter syndrome.
The reactions to mosquito bites are immunological reactions with involvement of IgE, IgG and T cells mediated hypersensitivity. These reactions are common and range from small local reactions, large local reactions to systemic allergic reactions. Skeeter syndrome is defined as a large local induced inflammatory reaction to mosquito bite and sometimes accompanied by systemic symptoms such as fever and vomiting. Diagnosis is based on clinical history and physical examination, supported by the identification of specific IgE by skin testing. Treatment includes prevention, antihistamines and steroids in some cases. Specific immunotherapy still requires further study. This paper reports two cases of patients with hypersensitivity reactions to mosquito bites, which were evaluated in our center presenting positive skin tests

Hypersensitivity to mosquito bite manifested as Skeeter sindrome. [Spanish]  
Perez-Vanzzini R, Gonzalez-Diaz SN, rias-Cruz A, Palma-Gomez S, Yong-Rodriguez A, Gutierrez-Mujica JJ, Garcia-Calderin D, Ibarra JA.
Rev Alerg Mex 2015 Jan;62(1):83-87

Click to view abstract

Index

Allergen-, Food allergy-, Intolerance-related articles

Allergen-Specific Tolerance Induction: Of Mice and Men.  
Pfutzner W.
Int Arch Allergy Immunol 2015 Mar 10;166(2):81-83

Allergen skin prick test should be adjusted by the histamine reactivity.  
Dreborg S.
Int Arch Allergy Immunol 2015 Mar 3;166(1):77-80
Click to view abstract

Evaluation of methods for the estimation of threshold concentrations by the skin prick test.  
Dreborg S, Holgersson M.
Int Arch Allergy Immunol 2015 Mar 3;166(1):71-76
Click to view abstract

IgE sensitization to lupine in bakers - cross-reactivity or co-sensitization to wheat flour?  
van K, Sander I, Quirce S, Bruning T, Merget R, Raulf M.
Int Arch Allergy Immunol 2015 Mar 3;166(1):63-70
Click to view abstract

Molecular diagnosis of shrimp allergy: efficiency of several allergens to predict clinical reactivity.  
Pascal M, Grishina G, Yang AC, Sanchez-Garcia S, Lin J, Towle D, Ibanez MD, Sastre J, Sampson HA, Ayuso R.
J Allergy Clin Immunol Pract 2015 Mar 11;
Click to view abstract

Penicillin stability in prefilled syringes for the purpose of skin testing for drug allergy.  
Garg A, Chan D, Ambados F, Lwin E, Song Y, Garg S.
J Allergy Clin Immunol Pract 2015 Mar 7;

Hypersensitivity to biological agents-updated diagnosis, management, and treatment.  
Galvao VR, Castells MC.
J Allergy Clin Immunol Pract 2015 Mar;3(2):175-185
Click to view abstract

Molecular cloning of a Poria cocos protein that activates Th1 immune response and allays Th2 cytokine and IgE production in a murine atopic dermatitis model.  
Lu YT, Kuan YC, Chang HH, Sheu F.
J Agric Food Chem 2014 Apr 2;62(13):2861-2871

Evaluation of reduced allergenicity of deamidated gliadin in a mouse model of wheat-gliadin allergy using an antibody prepared by a peptide containing three epitopes.  
Abe R, Shimizu S, Yasuda K, Sugai M, Okada Y, Chiba K, Akao M, Kumagai H, Kumagai H.
J Agric Food Chem 2014 Apr 2;62(13):2845-2852

Performance of ELISA and PCR methods for the determination of allergens in food: an evaluation of six years of proficiency testing for soy (Glycine max L.) and wheat gluten (Triticum aestivum L.).  
Scharf A, Kasel U, Wichmann G, Besler M.
J Agric Food Chem 2013 Oct 30;61(43):10261-10272

Identification of rice proteins recognized by the IgE antibodies of patients with food allergies.  
Golias J, Humlova Z, Halada P, Habova V, Janatkova I, Tuckova L.
J Agric Food Chem 2013 Sep 18;61(37):8851-8860

Evaluating pH-induced gastrointestinal aggregation of Arachis hypogaea 1 fragments as potential components of peanut allergy.  
Khan IJ, Di R, Patel P, Nanda V.
J Agric Food Chem 2013 Sep 4;61(35):8430-8435

Evaluation of endogenous allergens for the safety evaluation of genetically engineered food crops: review of potential risks, test methods, examples and relevance.  
Goodman RE, Panda R, Ariyarathna H.
J Agric Food Chem 2013 Sep 4;61(35):8317-8332

Effect of simulated gastric and intestinal digestion on temporal stability and immunoreactivity of peanut, almond, and pine nut protein allergens.  
Toomer OT, Do A, Pereira M, Williams K.
J Agric Food Chem 2013 Jun 19;61(24):5903-5913

Identification of an abundant 56 kDa protein implicated in food allergy as granule-bound starch synthase.  
Krishnan HB, Chen MH.
J Agric Food Chem 2013 Jun 5;61(22):5404-5409

Impact of thermal processing on ELISA detection of peanut allergens.  
Fu TJ, Maks N.
J Agric Food Chem 2013 Jun 19;61(24):5649-5658

Analysis to support allergen risk management: Which way to go?  
Cucu T, Jacxsens L, De Meulenaer B.
J Agric Food Chem 2013 Jun 19;61(24):5624-5633

Two quantitative real-time PCR assays for the detection of penaeid shrimp and blue crab, crustacean shellfish allergens.  
Eischeid AC, Kim BH, Kasko SM.
J Agric Food Chem 2013 Jun 19;61(24):5669-5674

Summary of the ACS symposium on Advances in Food Allergen Detection.  
Ross MM, Jackson L.
J Agric Food Chem 2013 Jun 19;61(24):5621-5623

Validation of quantitative and qualitative methods for detecting allergenic ingredients in processed foods in Japan.  
Sakai S, Adachi R, Akiyama H, Teshima R.
J Agric Food Chem 2013 Jun 19;61(24):5675-5680

Global proteomic screening of protein allergens and advanced glycation endproducts in thermally processed peanuts.  
Hebling CM, McFarland MA, Callahan JH, Ross MM.
J Agric Food Chem 2013 Jun 19;61(24):5638-5648

The regulatory challenge of food allergens.  
Gendel SM.
J Agric Food Chem 2013 Jun 19;61(24):5634-5637

Quantification of allergenic bovine milk alpha(S1)-casein in baked goods using an intact (1)(5)N-labeled protein internal standard.  
Newsome GA, Scholl PF.
J Agric Food Chem 2013 Jun 19;61(24):5659-5668

Mast-cell-based fluorescence biosensor for rapid detection of major fish allergen parvalbumin.  
Jiang D, Jiang H, Ji J, Sun X, Qian H, Zhang G, Tang L.
J Agric Food Chem 2014 Jul 9;62(27):6473-6480

Overview of plant chitinases identified as food allergens.  
Volpicella M, Leoni C, Fanizza I, Placido A, Pastorello EA, Ceci LR.
J Agric Food Chem 2014 Jun 25;62(25):5734-5742

2DLC-UV/MS assay for the simultaneous quantification of intact soybean allergens Gly m 4 and hydrophobic protein from soybean (HPS).  
Kuppannan K, Julka S, Karnoup A, Dielman D, Schafer B.
J Agric Food Chem 2014 May 28;62(21):4884-4892

Allergenicity of potato proteins and of their conjugates with galactose, galactooligosaccharides, and galactan in native, heated, and digested forms.  
Seo S, L'Hocine L, Karboune S.
J Agric Food Chem 2014 Apr 23;62(16):3591-3598

Selection of recombinant antibodies by phage display technology and application for detection of allergenic Brazil nut (Bertholletia excelsa) in processed foods.  
de la CS, Lopez-Calleja IM, Alcocer M, Gonzalez I, Martin R, Garcia T.
J Agric Food Chem 2013 Oct 30;61(43):10310-10319

The Citrus clementina putative allergens: from proteomic analysis to structural features.  
Serra IA, Bernardo L, Spadafora A, Faccioli P, Canton C, Mazzuca S.
J Agric Food Chem 2013 Sep 18;61(37):8949-8958

Accuracy of ELISA detection methods for gluten and reference materials: a realistic assessment.  
Diaz-Amigo C, Popping B
J Agric Food Chem 2013 Jun 19;61(24):5681-5688

Jug r 2-reactive CD4 T cells have a dominant immune role in walnut allergy.  
Archila LD, Jeong D, Pascal M, Bartra J, Juan M, Robinson D, Farrington ML, Kwok WW.
J Allergy Clin Immunol 2015 Mar 13;
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Hazelnut allergy across Europe dissected molecularly: A EuroPrevall outpatient clinic survey.  
Datema MR, Zuidmeer-Jongejan L, Asero R, Barreales L, Belohlavkova S, de BF, Bures P, Clausen M, Dubakiene R, Gislason D, Jedrzejczak-Czechowicz M, Kowalski ML, Knulst AC, Kralimarkova T, L.
J Allergy Clin Immunol 2015 Mar 13;
Click to view abstract

Exposure to allergen and diesel exhaust particles potentiates secondary allergen-specific memory responses, promoting asthma susceptibility.  
Brandt EB, Biagini Myers JM, Acciani TH, Ryan PH, Sivaprasad U, Ruff B, LeMasters GK, Bernstein DI, Lockey JE, LeCras TD, Khurana Hershey GK.
J Allergy Clin Immunol 2015 Mar 3;
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The alpha-gal story: Lessons learned from connecting the dots.  
Steinke JW, Platts-Mills TA, Commins SP.
J Allergy Clin Immunol 2015 Mar;135(3):589-596
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In vivo allergenic activity of a hypoallergenic mutant of the major fish allergen Cyp c 1 evaluated by means of skin testing.  
Douladiris N, Linhart B, Swoboda I, Gstottner A, Vassilopoulou E, Stolz F, Valenta R, Papadopoulos NG.
J Allergy Clin Immunol 2015 Mar 4;

Patients with positive skin test results to penicillin should not undergo penicillin or amoxicillin challenge.  
Park MA, Solensky R, Khan DA, Castells MC, Macy EM, Lang DM.
J Allergy Clin Immunol 2015 Mar;135(3):816-817

Identification of autoclave-resistant Anisakis simplex allergens.  
Carballeda-Sangiao N, Olivares F, Rodriguez-Mahillo AI, Careche M, Tejada M, Moneo I, Gonzalez-Munoz M.
J Food Prot 2014 Apr;77(4):605-609

Analysis of U.S. Food and Drug Administration food allergen recalls after implementation of the food allergen labeling and consumer protection act.  
Gendel SM, Zhu J.
J Food Prot 2013 Nov;76(11):1933-1938

A survey of food allergen control practices in the U.S. food industry.  
Gendel SM, Khan N, Yajnik M.
J Food Prot 2013 Feb;76(2):302-306

Patch testing with formaldehyde 2.0% in parallel with 1.0% by the Swedish contact dermatitis research group.  
Isaksson M, Brared-Christensson J, Engfeldt M, Lindberg M, Matura M, Moller H, Ryberg K, Stenberg B, Svedman C, Bruze M.
Acta Derm Venereol 2014 Jul;94(4):408-410
Click to view abstract

Usage tests of oak moss absolutes containing high and low levels of atranol and chloroatranol.  
Mowitz M, Svedman C, Zimerson E, Bruze M.
Acta Derm Venereol 2014 Jul;94(4):398-402
Click to view abstract

High prevalence of gluten sensitivity in a cohort of patients with undifferentiated connective tissue disease.  
Conti V, Leone MC, Casato M, Nicoli M, Granata G, Carlesimo M.
Eur Ann Allergy Clin Immunol 2015 Mar;47(2):54-57
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Single NSAID hypersensitivity is associated with atopic status.  
Asero R.
Eur Ann Allergy Clin Immunol 2015 Mar;47(2):48-53
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Position document: IgE-mediated cow's milk allergy.  
Martorell-Aragones A, Echeverria-Zudaire L, onso-Lebrero E, Bone-Calvo J, Martin-Munoz MF, Nevot-Falco S, Piquer-Gibert M, Valdesoiro-Navarrete L.
Allergol Immunopathol (Madr ) 2015 Mar 19;
Click to view abstract

Indoor determinants of dustborne allergens in Mexican homes.  
Hernandez-Cadena L, Zeldin DC, Barraza-Villarreal A, Sever ML, Sly PD, London SJ, Escamilla-Nunez MC, Romieu I.
Allergy Asthma Proc 2015 Mar;36(2):130-137
Click to view abstract

IgE Reactivity of the Dog Lipocalin Allergen Can f 4 and the Development of a Sandwich ELISA for Its Quantification.  
Rytkonen-Nissinen M, Saarelainen S, Randell J, Hayrinen J, Kalkkinen N, Virtanen T.
Allergy Asthma Immunol Res 2015 Mar 5;
Click to view abstract

Profiles of IgE Sensitization to Der f 1, Der f 2, Der f 6, Der f 8, Der f 10, and Der f 20 in Korean House Dust Mite Allergy Patients.  
Jeong KY, Lee JY, Son M, Yi MH, Yong TS, Shin JU, Lee KH, Kim YJ, Park KH, Park HJ, Lee JH, Park JW.
Allergy Asthma Immunol Res 2015 Mar 5;
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IgE-Binding Epitope Mapping and Tissue Localization of the Major American Cockroach Allergen Per a 2.  
Lee MF, Chang CW, Song PP, Hwang GY, Lin SJ, Chen YH.
Allergy Asthma Immunol Res 2015 Mar 5;
Click to view abstract

Seven steps to the diagnosis of NSAIDs hypersensitivity: how to apply a new classification in real practice?  
Kowalski ML, Makowska JS.
Allergy Asthma Immunol Res 2015 Mar 5;
Click to view abstract

An IgE-mediated allergic reaction caused by mulberry fruit.  
Choi JH, Sim JK, Oh JY, Hur GY, Min KH, Lee SY, Shim JJ, Kang KH.
Allergy Asthma Immunol Res 2015 Mar;7(2):195-198
Click to view abstract

Butter tolerance in children allergic to cow's milk.  
Yanagida N, Minoura T, Kitaoka S.
Allergy Asthma Immunol Res 2015 Mar;7(2):186-189
Click to view abstract

Japanese Cedar (Cryptomeria japonica) Pollinosis in Jeju, Korea: Is It Increasing?  
Lee J, Lee KH, Lee HS, Hong SC, Kim JH.
Allergy Asthma Immunol Res 2015 Mar 5;
Click to view abstract

Diagnostic decision points of specific IgE concentrations in Korean children with egg and cow's milk allergies.  
Kim J, Kim HY, Park MR, Choi J, Shim JY, Kim MJ, Han Y, Ahn K.
Allergy Asthma Immunol Res 2015 Mar 6;
Click to view abstract

The utility of specific IgE testing to chlorhexidine in the investigation of perioperative adverse reactions.  
Anderson J, Rose M, Green S, Fernando SL.
Ann Allergy Asthma Immunol 2015 Mar 3;

Occupational asthma and rhinoconjunctivitis by melon plant allergy.  
Gomez TE, Garcia RC, Garci aR, Mendez DY, Feo Brito FJ.
Ann Allergy Asthma Immunol 2015 Mar 3;

Longitudinal observation of children with enhanced total serum IgE.  
Daniluk U, Alifier M, Kaczmarski M, Stasiak-Barmuta A, Lebensztejn D.
Ann Allergy Asthma Immunol 2015 Mar 5;
Click to view abstract

Allergen of the month-narrowleaf goosefoot.  
Weber RW.
Ann Allergy Asthma Immunol 2015 Mar;114(3):A21

Prevalence of blueberry allergy in a Turkish population.  
Dereci S, Orhan F, Koca T, Akcam M.
Ann Allergy Asthma Immunol 2015 Mar;114(3):259-260

Specific IgE recognition of pollen allergens from subtropic grasses in patients from the subtropics.  
Nony E, Timbrell V, Hrabina M, Boutron M, Solley G, Moingeon P, Davies JM.
Ann Allergy Asthma Immunol 2015 Mar;114(3):214-220
Click to view abstract

Early-life mold and tree sensitivity is associated with allergic eosinophilic rhinitis at 4 years of age.  
Codispoti CD, Bernstein DI, Levin L, Reponen T, Ryan PH, Biagini Myers JM, Villareal M, Burkle J, Lummus Z, Lockey JE, Khurana Hershey GK, LeMasters GK.
Ann Allergy Asthma Immunol 2015 Mar;114(3):193-198
Click to view abstract

Cannabis sativa: the unconventional 'weed' allergen.  
Ocampo TL, Rans TS.
Ann Allergy Asthma Immunol 2015 Mar;114(3):187-192

Management of pollen food and oral allergy syndrome by health care professionals in the United Kingdom.  
Turner PJ, Dawson TC, Skypala IJ, Fox AT.
Ann Allergy Asthma Immunol 2015 Mar 12;

Eosinophilic esophagitis associated with Cynanchum wilfordii.  
Oh JY, Min KH, Park HS, Hur GY.
Ann Allergy Asthma Immunol 2015 Mar;114(3):257-259

A case of anaphylaxis caused by enokitake (flammulina velutipes) ingestion. [Japanese]  
Otsuji K, Ohara K, Nakamura M, Amazumi R, Higa C, Kakazu K, Kondo Y.
Arerugi 2015 Feb;64(1):63-67
Click to view abstract

Frequency of food group consumption and risk of allergic disease and sensitization in school children in urban and rural China.  
Yang Z, Zheng W, Yung E, Zhong N, Wong GW, Li J.
Clin Exp Allergy 2015 Mar 18;
Click to view abstract

Heterogeneous responses and cross reactivity between the major peanut allergens Ara h 1, 2,3 and 6 in a mouse model for peanut allergy.  
Smit JJ, Pennings MT, Willemsen K, van Roest M, van Hoffen E, Pieters RH.
Clin Transl Allergy 2015;513
Click to view abstract

Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs): classification of a Danish patient cohort according to EAACI/ENDA guidelines.  
Nissen CV, Bindslev-Jensen C, Mortz CG.
Clin Transl Allergy 2015;510
Click to view abstract

Physicochemical characteristics, functional properties, and nutritional benefits of peanut oil: a review.  
Akhtar S, Khalid N, Ahmed I, Shahzad A, Suleria HA.
Crit Rev Food Sci Nutr 2014;54(12):1562-1575

Advances of research on glycinin and beta-conglycinin: a review of two major soybean allergenic proteins.  
Wang T, Qin GX, Sun ZW, Zhao Y.
Crit Rev Food Sci Nutr 2014;54(7):850-862

Food allergy population thresholds: an evaluation of the number of oral food challenges and dosing schemes on the accuracy of threshold dose distribution modeling.  
Klein Entink RH, Remington BC, Blom WM, Rubingh CM, Kruizinga AG, Baumert JL, Taylor SL, Houben GF.
Food Chem Toxicol 2014 Aug;70134-143

House dust mite (Der p 10) and crustacean allergic patients may react to food containing Yellow mealworm proteins.  
Verhoeckx KC, van BS, den Hartog-Jager CF, Gaspari M, de Jong GA, Wichers HJ, van HE, Houben GF, Knulst AC.
Food Chem Toxicol 2014 Mar;65364-373

Fragrance material review on 1-(2,4-dimethyl-3-cyclohexenyl)-2,2-dimethylpropan-1-one.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S95-S99

Fragrance material review on 3-methyl-5-(2,2,3-trimethyl-3-cyclopenten-1-yl)pent-3-en-2-one.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S90-S94

Fragrance material review on 1-(3,3-dimethylcyclohexyl)pent-4-en-1-one.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S83-S89

Fragrance material review on 1-(5,5-dimethylcyclohexen-1-yl)pent-4-en-1-one.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S74-S82

Fragrance material review on methyl-2,6,10-trimethylcyclododeca-2,5,9-trien-1-yl ketone.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S67-S73

Fragrance material review on 1-[5(or 6)-methyl-7(or 8)-1-(methylethyl)bicyclo[2.2.2]oct-5-en-2-yl]ethan-1-one.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S61-S66

Fragrance material review on 1-(3,3-dimethylcyclohexyl)ethan-1-one.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S56-S60

Fragrance material review on 2-cyclohexyl-1,6-heptadien-3-one.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S51-S55

Fragrance material review on 1-spiro[4.5]dec-7-en-7-yl-4-pent-1-one.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S45-S50

Fragrance material review on 1-(para-menthen-6-yl)-1-propanone.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S133-S137

Fragrance material review on 1-(1,2,3,4,5,6,7,8-octahydro-2,3,8,8-tetramethyl-2-naphthalenyl)ethanone (OTNE).  
Scognamiglio J, Letizia CS, Politano VT, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S120-S132

Fragrance material review on 1-(2,6,6-trimethyl-2-cyclohexen-1-yl)pent-1-en-3-one.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S115-S119

Fragrance material review on 1-(3,3-dimethylbicyclo[2.2.1]hept-2-yl)ethane-1-one.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S110-S114

Fragrance material review on 1-(3,5,6-trimethyl-3-cyclohexen-1-yl)ethan-1-one.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S106-S109

Fragrance material review on 1-(2,4,4,5,5-pentamethyl-1-cyclopenten-1-yl)ethan-1-one.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S100-S105

A case study involving allergic reactions to sulfur-containing compounds including, sulfite, taurine, acesulfame potassium and sulfonamides.  
Stohs SJ, Miller MJ.
Food Chem Toxicol 2014 Jan;63240-243

Soy in wheat--contamination levels and food allergy risk assessment.  
Remington BC, Taylor SL, Marx DB, Petersen BJ, Baumert JL.
Food Chem Toxicol 2013 Dec;62485-491

Fragrance material review on acetyl carene.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S148-S151

Fragrance material review on cyclohexyl methyl pentanone.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S138-S143

Fragrance material review on 1-(2,5,5-trimethylcycloheptyl)ethan-1-one.  
Scognamiglio J, Letizia CS, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S144-S147

Fragrance material review on acetyl cedrene.  
Scognamiglio J, Letizia CS, Politano VT, Api AM.
Food Chem Toxicol 2013 Dec;62 Suppl 1S152-S166

Assessment of the respiratory sensitization potential of proteins using an enhanced mouse intranasal test (MINT).  
Krieger SM, Boverhof DR, Woolhiser MR, Hotchkiss JA.
Food Chem Toxicol 2013 Sep;59165-176

Advances in the risk management of unintended presence of allergenic foods in manufactured food products--an overview.  
Hattersley S, Ward R, Baka A, Crevel RW.
Food Chem Toxicol 2014 May;67255-261

Development and evolution of risk assessment for food allergens.  
Crevel RW, Baumert JL, Baka A, Houben GF, Knulst AC, Kruizinga AG, Luccioli S, Taylor SL, Madsen CB.
Food Chem Toxicol 2014 May;67262-276

Translating reference doses into allergen management practice: challenges for stakeholders.  
Crevel RW, Baumert JL, Luccioli S, Baka A, Hattersley S, Hourihane JO, Ronsmans S, Timmermans F, Ward R, Chung YJ.
Food Chem Toxicol 2014 May;67277-287

Allergenicity evaluation of fragrance mix and its ingredients by using ex vivo local lymph node assay-BrdU endpoints.  
Ulker OC, Kaymak Y, Karakaya A.
Food Chem Toxicol 2014 Mar;65162-167

Purification, physicochemical and immunological characterization of arginine kinase, an allergen of crayfish (Procambarus clarkii).  
Chen HL, Mao HY, Cao MJ, Cai QF, Su WJ, Zhang YX, Liu GM.
Food Chem Toxicol 2013 Dec;62475-484

Different anti-apoptotic effects of normal and asthmatic serum on normal eosinophil apoptosis depending on house dust mite-specific IgE.  
Kim IS, Kim MJ, Kim dH, Choi E, Lee JS.
Mol Biol Rep 2013 Oct;40(10):5875-5881

Effects of ovalbumin glycoconjugates on alleviation of orally induced egg allergy in mice via dendritic-cell maturation and T-cell activation.  
Rupa P, Nakamura S, Katayama S, Mine Y.
Mol Nutr Food Res 2014 Feb;58(2):405-417

Heat treatment of egg white controls allergic symptoms and induces oral tolerance to ovalbumin in a murine model of food allergy.  
Watanabe H, Toda M, Sekido H, Wellner A, Fujii T, Henle T, Hachimura S, Nakajima-Adachi H.
Mol Nutr Food Res 2014 Feb;58(2):394-404

IgG -antibodies and peanut challenge outcome in children IgE-sensitized to peanut.  
Glaumann S, Nilsson C, Asarnoj A, Moverare R, Johansson SG, Borres MP, Lilja G, Nopp A.
Pediatr Allergy Immunol 2015 Mar 16;
Click to view abstract

The significance of allergic contact urticaria to milk in children with cow's milk allergy.  
Schichter-Konfino V, Almog M, Bamberger E, Berkowitz D, Kessel A.
Pediatr Allergy Immunol 2015 Mar 16;
Click to view abstract

Dog and cat exposure and respective pet allergy in early childhood.  
Pyrhonen K, Nayha S, Laara E.
Pediatr Allergy Immunol 2015 Mar 2;
Click to view abstract

Categorisation of protein respiratory allergens: the case of Subtilisin.  
Kimber I, Basketter DA.
Regul Toxicol Pharmacol 2014 Apr;68(3):488-492

Computer models versus reality: how well do in silico models currently predict the sensitization potential of a substance.  
Teubner W, Mehling A, Schuster PX, Guth K, Worth A, Burton J, van RB, Landsiedel R.
Regul Toxicol Pharmacol 2013 Dec;67(3):468-485

Comparative assessment of multiple criteria for the in silico prediction of cross-reactivity of proteins to known allergens.  
Mirsky HP, Cressman RF, Ladics GS.
Regul Toxicol Pharmacol 2013 Nov;67(2):232-239

Hypersensitivity to mosquito bite manifested as Skeeter sindrome. [Spanish]  
Perez-Vanzzini R, Gonzalez-Diaz SN, rias-Cruz A, Palma-Gomez S, Yong-Rodriguez A, Gutierrez-Mujica JJ, Garcia-Calderin D, Ibarra JA.
Rev Alerg Mex 2015 Jan;62(1):83-87
Click to view abstract

Clinical-epidemiological profile of patients with suspicion of alimentary allergy in Mexico. Mexipreval Study. [Spanish]  
Medina-Hernandez A, Huerta-Hernandez RE, Gongora-Melendez MA, Dominguez-Silva MG, Mendoza-Hernandez DA, Romero-Tapia SJ, Idunate-Palacios F, Cisneros-Rivero MG, Covarrubias-Carrillo R.
Rev Alerg Mex 2015 Jan;62(1):28-40
Click to view abstract

Occupational asthma. [Spanish]  
Rico-Rosillo G, Cambray-Gutierrez JC, Vega-Robledo GB.
Rev Alerg Mex 2015 Jan;62(1):48-59
Click to view abstract

Prevalence of sensitization to cow's milk and egg among patients with suspicion of IgE mediated diseases. [Spanish]  
Mopan J, Sanchez J, Chinchilla C, Cardona R.
Rev Alerg Mex 2015 Jan;62(1):41-47
Click to view abstract

Chemical respiratory allergy: reverse engineering an adverse outcome pathway.  
Kimber I, Dearman RJ, Basketter DA, Boverhof DR.
Toxicology 2014 Apr 6;31832-39

The IgE response to Ascaris molecular components is associated with clinical indicators of asthma severity  
Buendía E, Zakzuk J, Mercado D, Alvarez A, Caraballo L
WAO Journal 2015;8:8
Click to view abstract Click to view abstract


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