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 Allergy Advisor Digest - July 2010
Editor: Dr. Harris A. Steinman

Journals List | Journals Captured this Month | ALL Articles captured this Month

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Read Exposure to dogs is associated with a decreased tumour necrosis factor-alpha-producing capacity in early life.
Read Respiratory allergy induced by exclusive polysensitization to serum albumins of furry animals.
Read Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanusyao.
Read Multiple epinephrine doses for stinging insect hypersensitivity reactions treated in the emergency department.
Read Arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization.
Read Survey on the prevalence of peanut, tree nut, and shellfish allergy in 2 Asian populations.
Read Specific IgE of common foods in Chinese children with eczema.

Abstracts shared in July 2010 Advisor Digest Newsletter

Read Socio-economic status, geographic remoteness and childhood food allergy and anaphylaxis in Australia.
Read How do we know when peanut and tree nut allergy have resolved, and how do we keep it resolved?
Read Impact of cross-reactive carbohydrate determinants on wood dust sensitization.
Read Component-based allergen-microarray in the diagnosis of cow's milk and hen's egg allergy.
Read Cypress pollen does not cross-react to plant-derived foods.
Read Prospective study of sensitization and food allergy to flaxseed in 1317 subjects.
Read Work-related sensitization and respiratory symptoms in carpentry apprentices exposed to wood dust and diisocyanates.
Read Severe type 1-allergy to raw bell pepper.
Read Gal d 6 is the second allergen characterized from egg yolk.

Allergy and Intolerance Abstracts
Exposure to dogs is associated with a decreased tumour necrosis factor-alpha-producing capacity in early life.
This study concludes that having a dog in the household in infancy and already during pregnancy may be associated with reduced innate immune responses in early childhood. "The observed attenuation of cytokine production may help in preventing exaggerated immune responses against harmless antigens later in life. Thus, intensive exposure to dogs in early life may be beneficial during normal immune maturation".

Exposure to dogs is associated with a decreased tumour necrosis factor-alpha-producing capacity in early life.  
Lappalainen MH, Huttunen K, Roponen M, Remes S, Hirvonen MR, Pekkanen J.
Clin Exp Allergy 2010 Jul 13;

Click to view abstract

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Allergy and Intolerance Abstracts
Respiratory allergy induced by exclusive polysensitization to serum albumins of furry animals.
A 27-year-old woman experienced conjunctival and severe respiratory symptoms after contact with several animals such as cats, dogs, rabbits, horses, cows etc. In vivo and in vitro procedures revealed allergic sensitization to animal-derived allergens only. Total IgE was 59.3 kU/L. Immunoblotting showed specific IgE-mediated sensitization to cow's, rabbit's and horse's serum albumins (SA). The authors conclude that this case confirms the role of serum albumen as cross-reacting agent in allergic sensitization to furry animals.

Respiratory allergy induced by exclusive polysensitization to serum albumins of furry animals.  
Liccardi G, Dente B, Restani P, Senna G, Falagiani P, Ballabio C, D'Amato G.
Eur Ann Allergy Clin Immunol 2010 Jun;42(3):127-130

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Index
Allergy and Intolerance Abstracts
Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanusyao.
Horsefly bite can cause allergic reactions in humans. This study purified and characterized IgE-binding proteins from horsefly salivary glands. Two IgE-binding proteins, Tab a 1 and Tab a 2 with molecular weight of 26 and 35 kd, respectively, were purified and characterized from horsefly salivary glands of Tabanus yao. Immunoblotting demonstrated IgE binding by 32 and 34 of 37 (86.5% and 91.8%) subjects' sera to Tab a 1 and Tab a 2, respectively. They were identified as an antigen 5-related (Ag 5) protein and hyaluronidase, respectively. In addition, these proteins showed some IgE-binding capacity to sera of subjects with wasp sting allergy. Therefore these allergens are thus not only found in stinging but also found in hematophagous insects. These results also provided support for the presence of the so-called wasp-horsefly syndrome (WHS).

Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanusyao.  
Ma D, Li Y, Dong J, An S, Wang Y, Liu C, Yang X, Yang H, Xu X, Lin D, Lai R.
Allergy 2010 Jul 2;

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Allergy and Intolerance Abstracts
Multiple epinephrine doses for stinging insect hypersensitivity reactions treated in the emergency department.
The object of this study was to establish the frequency of receiving more than 1 dose of epinephrine in patients presenting to the emergency department (ED) with stinging insect hypersensitivity (SIH) reactions. A medical record review of all 153 patients with SIH reactions presenting to 3 Eds in Boston, Massachusetts, were reviewed. Bees were the most frequently reported triggering insect (74%). A total of 59% of patients experienced large local reactions, whereas 36% had systemic reactions (10% cutaneous systemic and 26% anaphylaxis). Overall, 35% of patients with systemic reactions received epinephrine, and among this subset, 16% received more than 1 dose. Most patients with systemic reactions (67%) were discharged to home. Among patients with systemic SIH reactions who received epinephrine, 16% received a second dose. Physicians should consider prescribing 2 doses of self-injectable epinephrine for patients at risk for systemic SIH reactions.

Multiple epinephrine doses for stinging insect hypersensitivity reactions treated in the emergency department.  
Rudders SA, Banerji A, Katzman DP, Clark S, Camargo CA.
Ann Allergy Asthma Immunol 2010 Jul;105(1):85-93

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Allergy and Intolerance Abstracts
Arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization.
Extract from cowshed dust (CDE) is a source of immunomodulating substances. The authors have previously shown that such substances protect from experimental allergic disorders in a mouse model of asthma. The objective of this study was to identify immunomodulatory molecules in extracts of dust from an allergy protective farming environment. The authors found that plant arabinogalactans are contained in CDE in high concentrations. The source of this arabinogalactan is fodder, in particular a prevalent grass species known as Alopecurus pratensis. Treatment of murine dendritic cells with grass arabinogalactan resulted in autocrine IL-10 production. The authors conclude that grass arabinogalactans are important immunomodulatory substances that contribute to the protection from allergic airway inflammation, airway hyperresponsiveness, and atopic sensitization in a mouse model of asthma.

Arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization.  
Peters M, Kauth M, Scherner O, Gehlhar K, Steffen I, Wentker P, von ME, Holst O, Bufe A.
J Allergy Clin Immunol 2010 Jul 9;

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Allergy and Intolerance Abstracts
Survey on the prevalence of peanut, tree nut, and shellfish allergy in 2 Asian populations.
There has been a substantial increase in the prevalence of peanut and tree nut allergy in Western populations in the last 2 decades. However, there is an impression that peanut and tree nut allergy is relatively uncommon in Asia. This study evaluatee the prevalence of peanut, tree nut, and shellfish allergy in schoolchildren in 2 Asian countries (Singapore and Philippines). A total of 25,692 schoolchildren responded to the survey (response rate, 74.2%). Of these, 23,425 responses fell within the study protocol's 4 to 6 and 14 to 16 year age groups and were included in the analysis. The prevalence of convincing peanut and tree nut allergy were similar in both local Singapore (4-6 years, 0.64%, 0.28%; 14-16 years, 0.47%, 0.3%, respectively) and Philippine (14-16, 0.43%, 0.33%, respectively) schoolchildren, but was higher in the Singapore expatriates (4-6 years, 1.29%, 1.12%; 14-16 years, both 1.21%, respectively; 4-6 years, expatriates vs local Singaporeans: peanut). Conversely, shellfish allergy was more common in the local Singapore (4-6 years, 1.19%; 14-16 years, 5.23%) and Philippine (14-16 years, 5.12%) schoolchildren compared with expatriate children (4-6 years, 0.55%; 14-16 years, 0.96%). When data were pooled, respondents born in Western countries were at higher risk of peanut and tree nut allergy compared with those born in Asia.

A population-based questionnaire survey on the prevalence of peanut, tree nut, and shellfish allergy in 2 Asian populations.  
Shek LP, Cabrera-Morales EA, Soh SE, Gerez I, Ng PZ, Yi FC, Ma S, Lee BW.
J Allergy Clin Immunol 2010 Jul 10;

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Index
Allergy and Intolerance Abstracts
Specific IgE of common foods in Chinese children with eczema.
This Chinese study evaluated whether any association existed between atopic dermatitis (AD) severity, quality of life, total IgE, eosinophil counts, and the number of food items sensitized. Specific IgE of ten common food items was measured for a group of consecutive AD patients (n = 85) enrolled during a randomized trial and correlated the findings with eczema severity. Twenty-four patients (28%) were negative for any of the ten common food items. The most commonly sensitized foods were shrimp (54%), egg white (43%), wheat (42%), and peanut (41%). Atopy to beef as a protein and orange as a fruit were least common among the food items studied, even among patients positive for 8-9 IgE items.

Specific IgE of common foods in Chinese children with eczema.  
Hon KL, Chan IH, Chow CM, Wang SS, Lam CW, Ng PC, Leung TF.
Pediatr Allergy Immunol 2010 Jul 1;

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Index

Allergen-, Food allergy-, Intolerance-related articles

Authentication of food allergen quality by physicochemical and immunological methods.  
Sancho AI, Hoffmann-Sommergruber K, Alessandri S, Conti A, Giuffrida MG, Shewry P, Jensen BM, Skov P, Vieths S.
Clin Exp Allergy 2010 Jul;40(7):973-986
Click to view abstract

The role of cross-reactive carbohydrate determinants in the diagnosis of occupational allergy.  
Quirce S, Salcedo G.
Clin Exp Allergy 2010 Jul;40(7):962-964

Socio-economic status, geographic remoteness and childhood food allergy and anaphylaxis in Australia.  
Mullins RJ, Clark S, Camargo CA.
Clin Exp Allergy 2010 Jul 16;
Click to view abstract

CD14, a key candidate gene associated with a specific immune response to cockroach.  
Gao P, Grigoryev DN, Rafaels NM, Mu D, Wright JM, Cheadle C, Togias A, Beaty TH, Mathias RA, Schroeder JT, Barnes KC.
Clin Exp Allergy 2010 Jul 4;
Click to view abstract

Cow's milk allergy as a predictor of bronchial hyperresponsiveness and airway inflammation at school age.  
Malmberg LP, Saarinen KM, Pelkonen AS, Savilahti E, Makela MJ.
Clin Exp Allergy 2010 Jul 4;
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The HealthNuts population-based study of paediatric food allergy: validity, safety and acceptability.  
Osborne NJ, Koplin JJ, Martin PE, Gurrin LC, Thiele L, Tang ML, Ponsonby AL, Dharmage SC, Allen KJ.
Clin Exp Allergy 2010 Jul 1;
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How do we know when peanut and tree nut allergy have resolved, and how do we keep it resolved?  
Byrne AM, Malka-Rais J, Burks AW, Fleischer DM.
Clin Exp Allergy 2010 Jul 20;
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Impact of cross-reactive carbohydrate determinants on wood dust sensitization.  
Kespohl S, Schlunssen V, Jacobsen G, Schaumburg I, Maryska S, Meurer U, Bruning T, Sigsgaard T, Raulf-Heimsoth M.
Clin Exp Allergy 2010 Jul;40(7):1099-1106
Click to view abstract

Exposure to dogs is associated with a decreased tumour necrosis factor-alpha-producing capacity in early life.  
Lappalainen MH, Huttunen K, Roponen M, Remes S, Hirvonen MR, Pekkanen J.
Clin Exp Allergy 2010 Jul 13;
Click to view abstract

Performance of a component-based allergen-microarray in the diagnosis of cow's milk and hen's egg allergy.  
D'Urbano LE, Pellegrino K, Artesani MC, Donnanno S, Luciano R, Riccardi C, Tozzi AE, Rava L, De BF, Cavagni G.
Clin Exp Allergy 2010 Jul 13;
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IgG transmitted from allergic mothers decreases allergic sensitization in breastfed offspring.  
Matson AP, Thrall RS, Rafti E, Lingenheld EG, Puddington L.
Clin Mol Allergy 2010 Jul 13;8(1):9
Click to view abstract

Respiratory allergy induced by exclusive polysensitization to serum albumins of furry animals.  
Liccardi G, Dente B, Restani P, Senna G, Falagiani P, Ballabio C, D'Amato G.
Eur Ann Allergy Clin Immunol 2010 Jun;42(3):127-130
Click to view abstract

Cypress pollen does not cross-react to plant-derived foods.  
Panzani R, Ariano R, Mistrello G.
Eur Ann Allergy Clin Immunol 2010 Jun;42(3):125-126
Click to view abstract

Prospective study of sensitization and food allergy to flaxseed in 1317 subjects.  
Fremont S, Moneret-Vautrin DA, Franck P, Morisset M, Croizier A, Codreanu F, Kanny G.
Eur Ann Allergy Clin Immunol 2010 Jun;42(3):103-111
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Airborne allergy to tomato proteins.  
Asero R, Mistrello G, Amato S.
Allergy 2010 Jul 5;

The role of hen's egg-specific IgE, IgG and IgG4 in the diagnostic procedure of hen's egg allergy.  
Ahrens B, Lopes de Oliveira LC, Schulz G, Borres MP, Niggemann B, Wahn U, Beyer K.
Allergy 2010 Jul 5;
Click to view abstract

Purification and characterization of two new allergens from the salivary glands of the horsefly, Tabanusyao.  
Ma D, Li Y, Dong J, An S, Wang Y, Liu C, Yang X, Yang H, Xu X, Lin D, Lai R.
Allergy 2010 Jul 2;
Click to view abstract

Multiple epinephrine doses for stinging insect hypersensitivity reactions treated in the emergency department.  
Rudders SA, Banerji A, Katzman DP, Clark S, Camargo CA.
Ann Allergy Asthma Immunol 2010 Jul;105(1):85-93
Click to view abstract

Work-related sensitization and respiratory symptoms in carpentry apprentices exposed to wood dust and diisocyanates.  
Campo P, Aranda A, Rondon C, Donia I, az-Perales A, Canto G, Lisbona FJ, Pineda F, Blanca M.
Ann Allergy Asthma Immunol 2010 Jul;105(1):24-30
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Dermatophagoides species.  
Weber RW.
Ann Allergy Asthma Immunol 2010 Jul;105(1):A4

Detection of airborne Par j 1 and Par j 2 allergens in relation to Urticaceae pollen counts in different bioclimatic areas.  
Jato V, Rodriguez-Rajo FJ, Gonzalez-Parrado Z, Elvira-Rendueles B, Moreno-Grau S, Vega-Maray A, Fernandez-Gonzalez D, Asturias JA, Suarez-Cervera M.
Ann Allergy Asthma Immunol 2010 Jul;105(1):50-56
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Bronchial reactivity in schoolchildren allergic to food.  
Krogulska A, Dynowski J, Wasowska-Krolikowska K.
Ann Allergy Asthma Immunol 2010 Jul;105(1):31-38
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Severe type 1-allergy to raw bell pepper. [German]  
Ruger RD, Wagner S, Simon JC, Treudler R.
Hautarzt 2010 Apr;61(4):339-342

Cedar allergen harvest from tobacco: plant biotechnology for recombinant allergens.  
Takai T.
Int Arch Allergy Immunol 2010 Jul 14;153(4):431-433
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From Bench to Bedside: Use of Proteomics for Identification and Production of Recombinant Allergens.  
Andre C.
Int Arch Allergy Immunol 2010 Jul 14;153(4):428-430
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Gal d 6 is the second allergen characterized from egg yolk.  
Amo A, Rodríguez-Pérez R, Blanco J, Villota J, Juste S, Moneo I, Caballero ML.
J Agric Food Chem 2010 Jun 23;58(12):7453-7.
Abstract

The T-cell response to Amb a 1 is characterized by 3 dominant epitopes and multiple MHC restriction elements.  
Jahn-Schmid B, Wopfner N, Hubinger G, Asero R, Ebner C, Ferreira F, Bohle B.
J Allergy Clin Immunol 2010 Jul 15;

Hypoallergenic derivatives of the major birch pollen allergen Bet v 1 obtained by rational sequence reassembly.  
Campana R, Vrtala S, Maderegger B, Jertschin P, Stegfellner G, Swoboda I, Focke-Tejkl M, Blatt K, Gieras A, Zafred D, Neubauer A, Valent P, Keller W, Spitzauer S, Valenta R.
J Allergy Clin Immunol 2010 Jul 15;
Click to view abstract

Peanut-induced intestinal allergy is mediated through a mast cell-IgE-FcepsilonRI-IL-13 pathway.  
Wang M, Takeda K, Shiraishi Y, Okamoto M, Dakhama A, Joetham A, Gelfand EW.
J Allergy Clin Immunol 2010 Jul 10;
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Comparison of the allergic and nonallergic CD4(+) T-cell responses to the major dog allergen Can f 1.  
Parviainen S, Taivainen A, Liukko A, Nieminen A, Rytkonen-Nissinen M, Kinnunen T, Virtanen T.
J Allergy Clin Immunol 2010 Jul 10;

Arabinogalactan isolated from cowshed dust extract protects mice from allergic airway inflammation and sensitization.  
Peters M, Kauth M, Scherner O, Gehlhar K, Steffen I, Wentker P, von ME, Holst O, Bufe A.
J Allergy Clin Immunol 2010 Jul 9;
Click to view abstract

Food allergen advisory labeling and product contamination with egg, milk, and peanut.  
Ford LS, Taylor SL, Pacenza R, Niemann LM, Lambrecht DM, Sicherer SH.
J Allergy Clin Immunol 2010 Jul 9;

A population-based questionnaire survey on the prevalence of peanut, tree nut, and shellfish allergy in 2 Asian populations.  
Shek LP, Cabrera-Morales EA, Soh SE, Gerez I, Ng PZ, Yi FC, Ma S, Lee BW.
J Allergy Clin Immunol 2010 Jul 10;
Click to view abstract

Trends in pediatric emergency department visits for food-induced anaphylaxis.  
Rudders SA, Banerji A, Vassallo MF, Clark S, Camargo CA.
J Allergy Clin Immunol 2010 Jul 9;

Selective allergic reactions to clavulanic acid: a report of 9 cases.  
Sanchez-Morillas L, Perez-Ezquerra PR, Reano-Martos M, Laguna-Martinez JJ, Sanz ML, Martinez LM.
J Allergy Clin Immunol 2010 Jul;126(1):177-179

Specific IgE of common foods in Chinese children with eczema.  
Hon KL, Chan IH, Chow CM, Wang SS, Lam CW, Ng PC, Leung TF.
Pediatr Allergy Immunol 2010 Jul 1;
Click to view abstract

Sensitization patterns to food and inhalant allergens in childhood: A comparison of non-sensitized, monosensitized, and polysensitized children.  
Baatenburg de JA, Dikkeschei LD, Brand PL.
Pediatr Allergy Immunol 2010 Jul 13;


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