AllAllergy.Net - Allergy Advisor Digest

Allergy Advisor Digest - July 2017
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Snippets NOT posted in the July 2017 Advisor Digest Newsletter

Diagnosing allergic sensitizations in the third millennium: why clinicians should know allergen molecule structures.

Hidden causes of anaphylaxis.

Component resolved diagnostics for hymenoptera venom allergy.

Designing predictive models for beta-lactam allergy using the drug allergy and hypersensitivity database.

Low food allergy prevalence despite delayed introduction of allergenic foods

Methods in Allergy/Immunology: Food Challenges.

Prevalence of clinic-defined food allergy in early adolescence: The SchoolNuts study.

Effect of home exposure to Staphylococcus aureus on asthma in adolescents.

Specific allergen profiles of peanut foods and of diagnostic or therapeutic allergenic products.

Dose of allergens in a peanut snack (Bamba(R)) associated with prevention of peanut allergy.

The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up.

Is peanut causing food allergy in Cuba? Preliminary assessment of allergic sensitization and IgE specificity profile to peanut allergens in Cuban allergic patients.

Red meat allergy induced by tick bites: A Norwegian case report.

Phleum pratense molecular pattern across Italy.

House dust mites as potential carriers for IgE sensitisation to bacterial antigens.

Meat allergy associated with alpha-Gal - Closing diagnostic gaps by anti-alpha-Gal IgE immune profiling.

Usefulness of in vivo and in vitro diagnostic tests in the diagnosis of hypersensitivity reactions to quinolones and in the evaluation of cross-reactivity

In vitro diagnostic testing for antibiotic allergy.

Snippets posted in the July 2017 Advisor Digest Newsletter

		Contribution of molecular allergen analysis in diagnosis of milk allergy.
		Intimate behaviour and anaphylaxis
		Risk of anaphylaxis in complementary and alternative medicine.
		Intradermal skin testing in allergic rhinitis and asthma with negative skin prick tests.
		Enhanced Pru p 3 IgE binding activity by selective free fatty acid-interaction.
		Component-resolved diagnosis in hymenoptera allergy.
		Single and multiple food allergies in infants with proctocolitis.
		Tolerance to baked and fermented cow's milk in children with IgE-mediated and non-IgE-mediated cow's milk allergy in patients under two years of age.
		Utility of minor determinants for skin testing in inpatient penicillin allergy evaluation.
		Food allergy phenotypes: the key to personalized therapy.

Diagnosing allergic sensitizations in the third millennium: why clinicians should know allergen molecule structures.
Diagnostic tests to detect allergic sensitization were introduced at the end of the nineteenth century but only in the late 1990s did the advent of molecular allergology revolutionize the approach to the allergic patient. Personalized Medicine, a medical procedure that separates patients into different groups with different medical decisions, practices and interventions has sanctioned this change. In fact, in the last few years molecular allergology and the observation that not every patient has the same allergic profile, even when allergic to the same allergenic source, has originated the concept 'one size does not fit all'. This new approach requires the identification of still unknown allergens, but also the more detailed investigation of those already known. In depth studies of the structure-function relationships in allergenic molecules can reveal the structural determinants involved in the IgE-binding. Then, the knowledge of the epitope profile of each allergen and of the environmental/experimental conditions affecting the exposure of IgE-binding epitopes can provide important contributions to the understanding of cross-reaction processes and to the improvement of diagnosis, immunotherapy and the overall patient treatment. The evolution of diagnostic systems cannot ignore these new needs in this field.

Diagnosing allergic sensitizations in the third millennium: why clinicians should know allergen molecule structures.
Alessandri C, Ferrara R, Bernardi ML, Zennaro D, Tuppo L, Giangrieco I, Tamburrini M, Mari A, Ciardiello MA.
Clin Transl Allergy 2017;721

Hidden causes of anaphylaxis.
This study aimed to review important hidden causes of anaphylaxis in ingestants, non-ingestants, and uncommon settings. Multiple new and elusive causes of anaphylaxis have been described over the past 35 years. Further research is required to identify the epidemiology, pathophysiology, and clinical impact of these hidden causes. Although these culprits should be considered in the appropriate clinical scenarios, many remain exceedingly rare.

Hidden causes of anaphylaxis.
Nanagas VC, Baldwin JL, Karamched KR.
Curr Allergy Asthma Rep 2017 Jul;17(7):44

Component resolved diagnostics for hymenoptera venom allergy.
We review recent studies on the use of component-resolved diagnostics in the field of Hymenoptera venom allergy (HVA) and discuss its benefits and limitations. Component resolution in HVA has moved from single molecules to panels of allergens. Detection of specific immunoglobulin E (sigE) to marker and cross-reactive venom allergens has been reported to facilitate the discrimination between primary sensitization and cross-reactivity and thus, to provide a better rationale for prescribing venom immunotherapy (VIT), particularly in patients sensitized to both honeybee and vespid venom. Characterization of IgE reactivity to a broad panel of venom allergens has allowed the identification of different sensitization profiles that in honeybee venom allergy were associated with increased risks for side effects or treatment failure of VIT. In contrast, component resolution so far has failed to provide reliable markers for the discrimination of sensitizations to venoms of different members of Vespidae.

Component resolved diagnostics for hymenoptera venom allergy.
Jakob T, Muller U, Helbling A, Spillner E.
Curr Opin Allergy Clin Immunol 2017 Jul 29;

Designing predictive models for beta-lactam allergy using the drug allergy and hypersensitivity database.
The objectives of this study was to design predictive models for the diagnosis of beta-lactam allergy, based on the clinical history of patients with suspicions of allergic reactions to beta-lactams. The study concludes that two different independent methods using clinical history predictors were unable to accurately predict beta-lactam allergy and replace a conventional allergy evaluation for suspected beta-lactam allergy

Designing predictive models for beta-lactam allergy using the drug allergy and hypersensitivity database.
Chiriac AM, Wang Y, Schrijvers R, Bousquet PJ, Mura T, Molinari N, Demoly P.
J Allergy Clin Immunol Pract 2017 Jul 21;

Low food allergy prevalence despite delayed introduction of allergenic foods
There is mounting evidence that early introduction of allergenic food decreases the risk of food allergy development, especially in high-risk infants with eczema. However, there is a lack of data to suggest whether this association holds true in Asian populations. This study concludes that food allergy rates in Singapore are low despite delayed introduction of allergenic foods. Early introduction of allergenic foods may thus not be necessary in populations in which overall food allergy prevalence is low, and thus infant feeding recommendations should be carefully tailored to individual populations

Low food allergy prevalence despite delayed introduction of allergenic foods-data from the GUSTO Cohort.
Tham EH, Lee BW, Chan YH, Loo EXL, Toh JY, Goh A, Teoh OH, Yap F, Tan KH, Godfrey KM, Chong MFF, Van Bever HPS, Chong YS, Shek LP.
J Allergy Clin Immunol Pract 2017 Jul 19;

Methods in Allergy/Immunology: Food Challenges.
Since there is no in vitro test, which can accurately predict the clinical relevance of a sensitization to food, the oral food challenge still remains the most reliable procedure to confirm or exclude food allergy and to assess the development of tolerance in children with potentially transient food allergies such as to cow's milk, hen's egg, wheat or soy. Although in the last few years component-resolved diagnostic has improved the food allergy diagnostics, especially in peanut and tree nut allergy, the majority of patients still need to undergo oral food challenge. The following paper will describe in whom and how to perform an oral food challenge as well as its interpretation of the results with a focus on suspected IgE-mediated food allergy

Methods in Allergy/Immunology: Food Challenges.
Ballmer-Weber BK, Beyer K.
J Allergy Clin Immunol 2017 Jul 27;

Prevalence of clinic-defined food allergy in early adolescence: The SchoolNuts study.
Approximately 1 in 20 10- to 14-year-old school students in Melbourne has current food allergy. This high prevalence suggests that the previously reported rise in food-induced anaphylaxis in this age group may reflect an increasing prevalence of food allergy rather than simply increased reporting of anaphylaxis

Prevalence of clinic-defined food allergy in early adolescence: The SchoolNuts study.
Sasaki M, Koplin JJ, Dharmage SC, Field MJ, Sawyer SM, McWilliam V, Peters RL, Gurrin LC, Vuillermin PJ, Douglass J, Pezic A, Brewerton M, Tang MLK, Patton GC, Allen KJ.
J Allergy Clin Immunol 2017 Jul 21;

Effect of home exposure to Staphylococcus aureus on asthma in adolescents.
This is the first study to find that environmental Staphylococcus aureus and staphylococcal enterotoxins in a national population of inner-city adolescents with asthma are common and have the potential to drive asthma symptoms

Effect of home exposure to Staphylococcus aureus on asthma in adolescents.
Davis MF.
J Allergy Clin Immunol 2017 Jul 21;

Specific allergen profiles of peanut foods and of diagnostic or therapeutic allergenic products.
'Generic' immunoassays for peanut cannot discriminate between allergen levels in peanut derived food products or therapeutics. Clinical trials of oral immunotherapy are strengthened by using standardized peanut preparations, with defined doses of major allergens. This paper describes measurement of Ara h 1, Ara h 2 and Ara h 6 in peanut foods and in peanut flour extracts used for allergy diagnosis and oral immunotherapy. Roasted peanut butters contained 991-21,406mug/g Ara h 1 and exceeded Ara h 2 and Ara h 6 levels by 2-4 fold. Similarly, NIST SRM 2387 contained 11,275mug/g Ara h 1; 2,522mug/g Ara h 2 and 2,036mug/g Ara h 6. In contrast, peanut flours contained 787-14,631mug/g Ara h 2 and exceeded Ara h 1 levels by 2-20 fold. Flour extracts used for oral immunotherapy contained 394-505mug/ml Ara h 1, 1,187-5,270mug/ml Ara h 2 and 1,104-8,092mug/ml Ara h 6. In most cases, specific peanut allergens were not detected in tree nut butters or peanut oils. The results show marked differences in specific peanut allergen profiles in peanut butter, flour and peanut preparations for clinical use. Roasting may increase Ara h 1 levels in peanut butter. Variability in allergen levels could affect the outcome of clinical trials of peanut oral immunotherapy, especially with respect to Ara h 1. Specific allergen measurements will improve standardization and provide accurate dosing of peanut preparations that are being used for oral immunotherapy

Specific allergen profiles of peanut foods and of diagnostic or therapeutic allergenic products.
Filep S, Block D, Smith BRE, King EM, Commins S, Kulis M, Vickery BP, Chapman MD.
J Allergy Clin Immunol 2017 Jul 11;

Dose of allergens in a peanut snack (Bamba(R)) associated with prevention of peanut allergy.
This letter reports the dose of specific allergens (Ara h 1, Ara h 2 and Ara h 6) in the peanut snack (Bamba(R)) that was successfully used to prevent peanut allergy in the Learning Early About Peanut (LEAP) study. The results provide weekly doses of specific allergen that are associated with prevention of peanut allergy

Dose of allergens in a peanut snack (Bamba(R)) associated with prevention of peanut allergy.
Hindley JP, Filep S, Block D, King EM, Chapman MD.
J Allergy Clin Immunol 2017 Jul 11;

The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up.
Although the prevalence of food allergy decreased between age 1 year and age 4 years in this population-based cohort, the prevalence of any allergic disease among 4-year-old children in Melbourne, Australia, is remarkably high. The prevalence of challenge-confirmed food allergy at age 1 and 4 years was 11.0% and 3.8%, respectively. At age 4 years, peanut allergy prevalence was 1.9% (95% CI, 1.6% to 2.3%), egg allergy was 1.2% (95% CI, 0.9% to 1.6%), and sesame allergy was 0.4% (95% CI, 0.3% to 0.6%). Late-onset peanut allergy at age 4 years was rare (0.2%).

The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up.
Peters RL, Koplin JJ, Gurrin LC, Dharmage SC, Wake M, Ponsonby AL, Tang MLK, Lowe AJ, Matheson M, Dwyer T, Allen KJ.
J Allergy Clin Immunol 2017 Jul;140(1):145-153

Is peanut causing food allergy in Cuba? Preliminary assessment of allergic sensitization and IgE specificity profile to peanut allergens in Cuban allergic patients.
The study estimated a relatively high prevalence of peanut sensitization in population. Data reported here suggest that IgE sensitization in Cuban patients is focused mostly on MW bands corresponding to the major allergens Ara h 6 and Ara h 2.

Is peanut causing food allergy in Cuba? Preliminary assessment of allergic sensitization and IgE specificity profile to peanut allergens in Cuban allergic patients.
Mateo-Morejon M, Labrada-Rosado A, Torralba-Averoff D, Cruz-Jimenez R, Oliva-Diaz Y, varez-Castello M, Ciria-Martin A, Jimenez-Frandin M, Reyes-Zamora MC, Castro-Almarales RL, Tamarg.
World Allergy Organ J 2017;10(1):26

Red meat allergy induced by tick bites: A Norwegian case report.
Food allergies, especially delayed hypersensitivity reactions, are often challenging for both patients and clinicians. Here, we report the case of a 64-year-old man who had allergic reactions six hours after eating a meal containing red meat. He reported that he had several tick bites in months before the reaction. High serum specific IgE levels of alpha-gal confirmed the diagnosis of alpha-gal allergic reaction with delayed onset after red meat ingestion caused by tick bite

Red meat allergy induced by tick bites: A Norwegian case report.
Arslan LG.
Eur Ann Allergy Clin Immunol 2017 Jul;49(4):186-188

Phleum pratense molecular pattern across Italy.
Phleum pratense (Timothy grass) is the most frequent cause of grass allergy in Europe. The present study was aimed to investigate the possible relationships between Graminaceae pollen data and the pattern of IgE reactivity to different allergen components across Italy. Pollen data, including duration and quantity, were recorded over a 10-year period in 24 Italian centres located along the Italian peninsula. Phl p molecular patterns (Phl p 1, 5, 7, 12) were evaluated in 4 different Italian geographical areas. There were significant differences about pollen count and sensitization prevalence across Italy. Different molecular patterns were defined considering the different Italian locations.

Phleum pratense molecular pattern across Italy.
Ciprandi G, Scala E, Ariano R.
Eur Ann Allergy Clin Immunol 2017 Jul;49(4):176-180

House dust mites as potential carriers for IgE sensitisation to bacterial antigens.
This article argues that HDM may serve as carriers of bacteria responsible for the induction of IgE sensitisation to microbial antigens.

House dust mites as potential carriers for IgE sensitisation to bacterial antigens.
Dzoro S, Mittermann I, Resch Y, Vrtala S, Nehr M, Hirschl AM, Wikberg G, Lundeberg L, Johansson C, Scheynius A, Valenta R.
Allergy 2017 Jul 25;

Meat allergy associated with alpha-Gal - Closing diagnostic gaps by anti-alpha-Gal IgE immune profiling.
Glycoproteins and glycolipids of some mammalian species contain the disaccharide galactosyl-alpha-(1,3)-galactose (alpha-Gal). It is known that alpha-Gal is immunogenic in humans and causes glycan-specific IgG and also IgE responses with clinical relevance. alpha-Gal is part of the IgE-reactive monoclonal therapeutic antibody cetuximab and is associated with delayed anaphylaxis to red meat. In this study, different alpha-Gal-containing analytes are examined in singleplex and multiplex assays to resolve individual sensitization patterns with IgE against alpha-Gal.

Three serum groups, alpha-Gal-associated meat allergy (MA) patients, idiopathic anaphylaxis (IA) patients with suspected meat allergy and non-meat-allergic healthy control individuals (HC), were analyzed via singleplex allergy diagnostics and a newly established immunoblot diagnostic system. The new dot blot detection system resolved individual IgE sensitization profiles for alpha-Gal-containing analytes cetuximab, bovine thyroglobulin and HSA-conjugated alpha-Gal.

Singleplex allergy diagnostics using the alpha-Gal-analytes cetuximab and bovine thyroglobulin confirms the history of meat allergy patients in 91% and 88% of the cases, respectively. A novel dot-blot-based assay system for the detection of IgE against alpha-Gal reveals individual IgE sensitization profiles for alpha-Gal-containing analytes. An alpha-Gal-associated IgE cross-reactivity profile (IgE against cetuximab, bovine thyroglobulin and HSA-alpha-Gal) was identified, which is associated with meat allergy.

Detection of individual sensitization patterns with different alpha-Gal-containing analytes provides the basis for an individual allergy diagnosis for alpha-Gal sensitized patients. Higher amounts of alpha-Gal in pork and beef innards compared to muscle meat as indicated by a higher staining intensity are a plausible explanation for the difference in allergic symptom severity.

Meat allergy associated with alpha-Gal - Closing diagnostic gaps by anti-alpha-Gal IgE immune profiling.
Jappe U, Minge S, Kreft B, Ludwig A, Przybilla B, Walker A, Varga R, Seidel P, Biedermann T, Anemuller W, Kromminga A, Rueff F, Merk H, Wagner N, Treudler R, Worm M, Waldmann I, Saloga J, Be.
Allergy 2017 Jul 3;

Usefulness of in vivo and in vitro diagnostic tests in the diagnosis of hypersensitivity reactions to quinolones and in the evaluation of cross-reactivity
Reports evaluating diagnosis and cross reactivity of quinolone hypersensitivity have revealed contradictory results. Furthermore, there are no reports investigating the cross-reactivity between gemifloxacin (GFX) and the others. We aimed to detect the usefulness of diagnostic tests of hypersensitivity reactions to quinolones and to evaluate the cross reactivity between different quinolones including the latest quinolone GFX. We studied 54 patients (mean age 42.31+/-10.39 years; 47 female) with 57 hypersensitivity reactions due to different quinolones and 10 nonatopic quinolone tolerable control subjects. A detailed clinical history, skin test (ST), and single-blind placebo-controlled drug provocation test (SBPCDPT), as well as basophil activation test (BAT) and lymphocyte transformation test (LTT) were performed with the culprit and alternative quinolones including ciprofloxacin (CFX), moxifloxacin (MFX), levofloxacin (LFX), ofloxacin (OFX), and GFX.

The majority (75.9%) of the patients reported immediate type reactions to various quinolones. The most common culprit drug was CFX (52.6%) and the most common reaction type was urticaria (26.3%). A quarter of the patients (24.1%) reacted to SBPCDPTs, although their STs were negative; while false ST positivity was 3.5% and ST/SBPCDPTs concordance was only 1.8%. Both BAT and LTT were not found useful in quinolone hypersensitivity. Cross-reactivity was primarily observed between LFX and OFX (50.0%), whereas it was the least between MFX and the others, and in GFX hypersensitive patients the degree of cross-reactivity to the other quinolones was 16.7%. These results suggest that STs, BAT, and LTT are not supportive in the diagnosis of a hypersensitivity reaction to quinolone as well as in the prediction of cross-reactivity. Drug provocation tests (DPTs) are necessary to identify both culprit and alternative quinolones

Usefulness of in vivo and in vitro diagnostic tests in the diagnosis of hypersensitivity reactions to quinolones and in the evaluation of cross-reactivity: A comprehensive study including the latest quinolone Gemifloxacin.
Demir S, Gelincik A, Akdeniz N, ktas-Cetin E, Olgac M, Unal D, Ertek B, Coskun R, Colakoglu B, Deniz G, Buyukozturk S.
Allergy Asthma Immunol Res 2017 Jul;9(4):347-359

In vitro diagnostic testing for antibiotic allergy.
Allergy to antibiotics is an important worldwide problem, with an estimated prevalence of up to 10% of the population. Reaction patterns for different antibiotics have changed in accordance with consumption trends. Most of the allergic reactions to antibiotics have been reported for betalactams, followed by quinolones and macrolides and, to a lesser extent, to others, such as metronidazole clindamycin and sulfonamides. The diagnostic procedure includes a detailed clinical history, which is not always possible and can be unreliable. This is usually followed by in vivo, skin, and drug provocation tests. These are not recommended for severe, potentially lifethreaten reactions or for drugs that are known to produce a high rate of false positive results. Given the limitations of in vivo tests, in vitro test can be helpful for diagnosis, despite having suboptimal sensitivity. The most highly employed techniques for diagnosing immediate reactions to antibiotics are immunoassays and basophil activation tests, while lymphocyte transformation tests are more commonly used to diagnose non-immediate reactions. In this review, we describe different in vitro techniques employed to diagnose antibiotic allergy

In vitro diagnostic testing for antibiotic allergy.
Dona I, Torres MJ, Montanez MI, Fernandez TD.
Allergy Asthma Immunol Res 2017 Jul;9(4):288-298

Allergen-, Food allergy-, Intolerance-related articles

Diagnosing allergic sensitizations in the third millennium: why clinicians should know allergen molecule structures.
Alessandri C, Ferrara R, Bernardi ML, Zennaro D, Tuppo L, Giangrieco I, Tamburrini M, Mari A, Ciardiello MA. Clin Transl Allergy 2017;721

Health Related Quality of Life among schoolchildren aged 12-13 years in relation to food hypersensitivity phenotypes: a population-based study.
Strinnholm A, Hedman L, Winberg A, Jansson SA, Lindh V, Ronmark E. Clin Transl Allergy 2017;720

Nanotechnologies for In Vitro IgE Testing.
Marki I, Rebeaud F. Curr Allergy Asthma Rep 2017 Jul;17(7):50

Contribution of molecular allergen analysis in diagnosis of milk allergy.
Bartuzi Z, Cocco RR, Muraro A, Nowak-Wegrzyn A. Curr Allergy Asthma Rep 2017 Jul;17(7):46

Hidden causes of anaphylaxis.
Nanagas VC, Baldwin JL, Karamched KR. Curr Allergy Asthma Rep 2017 Jul;17(7):44

Component resolved diagnostics for hymenoptera venom allergy.
Jakob T, Muller U, Helbling A, Spillner E. Curr Opin Allergy Clin Immunol 2017 Jul 29;

Anaphylaxis and intimate behaviour.
Liccardi G, Caminati M, Senna GE, Calzetta L, Rogliani P. Curr Opin Allergy Clin Immunol 2017 Jul 22;

Risk of anaphylaxis in complementary and alternative medicine.
Gunawardana NC. Curr Opin Allergy Clin Immunol 2017 Jul 20;

Intradermal skin testing in allergic rhinitis and asthma with negative skin prick tests.
Erel F, Sarioglu N, Kose M, Kaymakci M, Gokcen M, Kepekci AH, Arslan M. Iran J Allergy Asthma Immunol 2017 Jun;16(3):193-197

Designing predictive models for beta-lactam allergy using the drug allergy and hypersensitivity database.
Chiriac AM, Wang Y, Schrijvers R, Bousquet PJ, Mura T, Molinari N, Demoly P. J Allergy Clin Immunol Pract 2017 Jul 21;

Low food allergy prevalence despite delayed introduction of allergenic foods-data from the GUSTO Cohort.
Tham EH, Lee BW, Chan YH, Loo EXL, Toh JY, Goh A, Teoh OH, Yap F, Tan KH, Godfrey KM, Chong MFF, Van Bever HPS, Chong YS, Shek LP. J Allergy Clin Immunol Pract 2017 Jul 19;

Four cases of delayed onset systemic reaction to shellfish.
Huffaker MF, McGhee SA. J Allergy Clin Immunol Pract 2017 Jul 19;

Methods in Allergy/Immunology: Food Challenges.
Ballmer-Weber BK, Beyer K. J Allergy Clin Immunol 2017 Jul 27;

Prevalence of clinic-defined food allergy in early adolescence: The SchoolNuts study.
Sasaki M, Koplin JJ, Dharmage SC, Field MJ, Sawyer SM, McWilliam V, Peters RL, Gurrin LC, Vuillermin PJ, Douglass J, Pezic A, Brewerton M, Tang MLK, Patton GC, Allen KJ. J Allergy Clin Immunol 2017 Jul 21;

Effect of home exposure to Staphylococcus aureus on asthma in adolescents.
Davis MF. J Allergy Clin Immunol 2017 Jul 21;

Sialylation of IgG antibodies inhibits IgG-mediated allergic reactions.
Epp A, Hobusch J, Bartsch YC, Petry J, Lilienthal GM, Koeleman CAM, Eschweiler S, Mobs C, Hall A, Morris SC, Braumann D, Engellenner C, Bitterling J, Rahmoller J, Leliavski A, Thurmann R, . J Allergy Clin Immunol 2017 Jul 17;

Enhanced Pru p 3 IgE binding activity by selective free fatty acid-interaction.
Dubiela P, Aina R, Polak D, Geiselhart S, Humeniuk P, Bohle B, Alessandri S, Del CR, Cantini F, Borowski T, Bublin M, Hoffmann-Sommergruber K. J Allergy Clin Immunol 2017 Jul 14;

Specific allergen profiles of peanut foods and of diagnostic or therapeutic allergenic products.
Filep S, Block D, Smith BRE, King EM, Commins S, Kulis M, Vickery BP, Chapman MD. J Allergy Clin Immunol 2017 Jul 11;

Dose of allergens in a peanut snack (Bamba(R)) associated with prevention of peanut allergy.
Hindley JP, Filep S, Block D, King EM, Chapman MD. J Allergy Clin Immunol 2017 Jul 11;

The prevalence of food allergy and other allergic diseases in early childhood in a population-based study: HealthNuts age 4-year follow-up.
Peters RL, Koplin JJ, Gurrin LC, Dharmage SC, Wake M, Ponsonby AL, Tang MLK, Lowe AJ, Matheson M, Dwyer T, Allen KJ. J Allergy Clin Immunol 2017 Jul;140(1):145-153

Anaphylaxis to horses and epinephrine use-increasing awareness among pediatric patients and families.
Cosme-Blanco W, Lopez E, Morales-Bronner S, Blouin W, Hernandez-Trujillo V. Pediatr Allergy Immunol 2017 Jul 7;

Sensitization to 10 mites in a tropic area. Der p and Der f are important risk factor for sensitization to other mites from Pyroglyphidae, Acaridae, Chortoglyphidae, and Glyciphagidae familie. [Spanish]
Sanchez J, Calvo V, Sanchez A, Diez S, Cardona R. Rev Alerg Mex 2017 Apr;64(2):153-162

Clinical-epidemiological profile of oral allergy syndrome in the population aged 6 to 18 years. [Spanish]
zamar-Jacome AA, zamar-Jacome MA, Borjas-Aguilar KL, Mendoza-Hernandez DA, Huerta-Lopez JG. Rev Alerg Mex 2017 Apr;64(2):142-152

Is peanut causing food allergy in Cuba? Preliminary assessment of allergic sensitization and IgE specificity profile to peanut allergens in Cuban allergic patients.
Mateo-Morejon M, Labrada-Rosado A, Torralba-Averoff D, Cruz-Jimenez R, Oliva-Diaz Y, varez-Castello M, Ciria-Martin A, Jimenez-Frandin M, Reyes-Zamora MC, Castro-Almarales RL, Tamarg. World Allergy Organ J 2017;10(1):26

Red meat allergy induced by tick bites: A Norwegian case report.
Arslan LG. Eur Ann Allergy Clin Immunol 2017 Jul;49(4):186-188

Effects of food allergy on the dietary habits and intake of primary schools' Cypriot children.
Vassilopoulou E, Christoforou C, Andreou E, Heraclides A. Eur Ann Allergy Clin Immunol 2017 Jul;49(4):181-185

Phleum pratense molecular pattern across Italy.
Ciprandi G, Scala E, Ariano R. Eur Ann Allergy Clin Immunol 2017 Jul;49(4):176-180

Evaluation of the frequency of food allergens based on skin prick test in children in Kurdistan Province - Iran.
Kalmarzi R, Ataee P, Homagostar G, Tagik M, Ghaderi E, Kooti W. Allergol Immunopathol (Madr ) 2017 Jul 24;

Component-resolved diagnosis in hymenoptera allergy.
Antolín-Amérigo D, Ruiz-León B, Boni E, Alfaya-Arias T, Álvarez-Mon M, Barbarroja-Escudero J, González-de-Olano D, Moreno-Aguilar C, Rodríguez-Rodríguez M, Sánchez-González MJ, et al. Allergol Immunopathol (Madr ) 2017 Jul 21;

Single and multiple food allergies in infants with proctocolitis.
Koksal BT, Baris Z, Ozcay F, Yilmaz OO. Allergol Immunopathol (Madr ) 2017 Jul 21;

Tolerance to baked and fermented cow's milk in children with IgE-mediated and non-IgE-mediated cow's milk allergy in patients under two years of age.
Uncuoglu A, Yologlu N, Simsek IE, Uyan ZS, Aydogan M. Allergol Immunopathol (Madr ) 2017 Jul 15;

Immediate-type allergic reactions to local anesthetics.
Nakamura N, Tamagawa-Mineoka R, Masuda K, Katoh N. Allergol Int 2017 Jul 19;

House dust mites as potential carriers for IgE sensitisation to bacterial antigens.
Dzoro S, Mittermann I, Resch Y, Vrtala S, Nehr M, Hirschl AM, Wikberg G, Lundeberg L, Johansson C, Scheynius A, Valenta R. Allergy 2017 Jul 25;

Computational validation of the recently proposed pollen season definition criteria.
Karatzas K, Riga M, Berger U, Werchan M, Pfaar O, Bergmann KC. Allergy 2017 Jul 18;

Meat allergy associated with alpha-Gal - Closing diagnostic gaps by anti-alpha-Gal IgE immune profiling.
Jappe U, Minge S, Kreft B, Ludwig A, Przybilla B, Walker A, Varga R, Seidel P, Biedermann T, Anemuller W, Kromminga A, Rueff F, Merk H, Wagner N, Treudler R, Worm M, Waldmann I, Saloga J, Be. Allergy 2017 Jul 3;

Usefulness of in vivo and in vitro diagnostic tests in the diagnosis of hypersensitivity reactions to quinolones and in the evaluation of cross-reactivity: A comprehensive study including the latest quinolone Gemifloxacin.
Demir S, Gelincik A, Akdeniz N, ktas-Cetin E, Olgac M, Unal D, Ertek B, Coskun R, Colakoglu B, Deniz G, Buyukozturk S. Allergy Asthma Immunol Res 2017 Jul;9(4):347-359

In vitro diagnostic testing for antibiotic allergy.
Dona I, Torres MJ, Montanez MI, Fernandez TD. Allergy Asthma Immunol Res 2017 Jul;9(4):288-298

Sesame allergy in adults: Investigation and outcomes of oral food challenges.
Li PH, Gunawardana N, Thomas I, Ue KL, Siew L, Watts TJ, Bintcliffe K, Haque R, Rutkowski K, Skypala I, Till SJ. Ann Allergy Asthma Immunol 2017 Jul 22;

Utility of minor determinants for skin testing in inpatient penicillin allergy evaluation.
Geng B, Eastman JJ, Mori K, Braskett M, Riedl MA. Ann Allergy Asthma Immunol 2017 Jul 22;

Delayed stinging insect reactions.
Abrams EM, Becker AB. Ann Allergy Asthma Immunol 2017 Jul 20;

Effects of allergen sensitization on response to therapy in children with eosinophilic esophagitis.
Pesek RD, Rettiganti M, O'Brien E, Beckwith S, Daniel C, Luo C, Scurlock AM, Chandler P, Levy RA, Perry TT, Kennedy JL, Chervinskiy S, Vonlanthen M, Casteel H, Fiedorek SC, Gibbons T, Jones SM. Ann Allergy Asthma Immunol 2017 Jul 1;

Grasshopper anaphylaxis in patients allergic to dust mite, cockroach, and crustaceans: Is tropomyosin the cause?
Sokol WN, Wunschmann S, Agah S. Ann Allergy Asthma Immunol 2017 Jul;119(1):91-92

Drug eruption caused by memantine.
Saito R, Sawada Y, Yamaguchi T, Ohmori S, Haruyama S, Yoshioka M, Okada E, Nakamura M. Ann Allergy Asthma Immunol 2017 Jul;119(1):89-90

Cockroach allergen exposure and plasma cytokines among children in a tropical environment.
Medsker BH, Forno E, Han YY, costa-Perez E, Colon-Semidey A, Alvarez M, Alcorn JF, Canino GJ, Celedon JC. Ann Allergy Asthma Immunol 2017 Jul;119(1):65-70

Mammalian raw materials used to produce allergen extracts.
Fernandez-Caldas E, Cases B, El-Qutob D, Cantillo JF. Ann Allergy Asthma Immunol 2017 Jul;119(1):1-8

Association of IgE Can f 2 and dyspnea in pet allergic patients.
Ukleja-Sokolowska N, Gawronska-Ukleja E, Zbikowska-Gotz M, Socha E, Lis K, Sokolowski L, Bartuzi Z. Ann Allergy Asthma Immunol 2017 Jul;119(1):86-88

Accurate quantification of five German cockroach (GCr) allergens in complex extracts using multiple reaction monitoring mass spectrometry (MRM MS).
Mindaye ST, Spiric J, David NA, Rabin RL, Slater JE. Clin Exp Allergy 2017 Jul 30;

Food allergy phenotypes: the key to personalized therapy.
Deschildre A, Lejeune S, Cap M, Flammarion S, Jouannic L, Amat F, Just J. Clin Exp Allergy 2017 Jul 15;

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