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 Allergy Advisor Digest - June 2017
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Snippets NOT posted in the June 2017 Advisor Digest Newsletter

Read A prospective microbiome-wide association study of food sensitization and food allergy in early childhood.
Read Drug allergy evaluation for betalactam hypersensitivity: Cross-reactivity with cephalosporines, carbapenems and negative predictive value.
Read Cross-React: a new structural bioinformatics method for predicting allergen cross-reactivity.
Read Artificial sweeteners and mixture of food additives cause to break oral tolerance and induce food allergy in murine oral tolerance model for food allergy.
Read Anticonvulsant hypersensitivity syndrome after phenytoin administration in an adolescent patient
Read Systemic allergic dermatitis caused by sesquiterpene lactones.
Read Evaluation of penicillin allergy in the hospitalized patient: opportunities for antimicrobial stewardship.
Read Patient-centered outcomes in food allergy.
Read Molecular aspects of allergens in atopic dermatitis.
Read Apheresis in food allergies.
Read Contact allergy cross-reactions: retrospective clinical data and review of the literature.
Read Impact of traffic-related air pollution on the expression of Platanus orientalis (Oriental Plane tree) pollen allergens.
Read Sensitising effects of genetically modified enzymes used in flavour, fragrance, detergence and pharmaceutical production: cross-sectional study.
Read Risk factors for developing food-induced bronchospasm during oral food challenge.
Read Contact alopecia: improvement of alopecia with discontinuation of fluocinolone oil in individuals allergic to balsam fragrance.
Read Species identification and prevalence of house dust mites as respiratory allergen in kindergartens of the Bandar Abbas City.
Read Triosephosphate Isomerase and Filamin C share common epitopes as novel allergens of Procambarus clarkii.
Read Purification and Characterization of a Black Walnut (Juglans nigra) allergen, Jug n 4.
Read Allergy testing in predicting outcome of open food challenge to peanut.
Read Troponin as a cause of hypersensitivity to barnacle.

Snippets posted in the June 2017 Advisor Digest Newsletter

Read Identification of a novel food allergen in lotus root.
Read A case of eel collagen allergy.
Read A case of green tea (Camellia sinensis) imbibement causing possible anaphylaxis.
Read Modifying the infant's diet to prevent food allergy.
Read Component resolved diagnosis in hymenoptera anaphylaxis.
Read Evaluation of food allergy in children by skin prick tests with commercial extracts and fresh foods, specific IgE and, open oral food challenge-our five years experience in food allergy work-up.
Read Natural variability of allergen levels in conventional soybeans: assessing variation across north and South America from five production Years.
Read Distribution of peanut protein in school and home environments of inner-city children.
Read A limited survey of dark chocolate bars obtained in the United States for undeclared milk and peanut allergens.
Read Component-resolved diagnosis of dog allergy.
Read Steps towards clarifying the clinical relevance of minor olive allergens in areas with extremely high levels of olive pollen.

Allergy and Intolerance Abstracts
A prospective microbiome-wide association study of food sensitization and food allergy in early childhood.
The temporal association between bacterial colonization and food sensitization and allergy suggests that the microbiome may have a causal role in the development of food allergy. Our findings have therapeutic implications for the prevention and treatment of food allergy.

A prospective microbiome-wide association study of food sensitization and food allergy in early childhood.  
Savage JH, Lee-Sarwar KA, Sordillo J, Bunyavanich S, Zhou Y, O'Connor G, Sandel M, Bacharier L, Zeiger R, Sodergren E, Weinstock GM, Gold DR, Weiss ST, Litonjua AA.
Allergy 2017 Jun 20;

Index
Allergy and Intolerance Abstracts
Drug allergy evaluation for betalactam hypersensitivity: Cross-reactivity with cephalosporines, carbapenems and negative predictive value.
Carbapenems and cephalosporines can be safely given to penicillin allergic patients by means of skin testing and if negative, proceeding with a graded challenge. Our calculated NPV for penicillin testing is similar to other studies.

Drug allergy evaluation for betalactam hypersensitivity: Cross-reactivity with cephalosporines, carbapenems and negative predictive value.  
Al-Ahmad M, Rodriguez-Bouza T.
Asian Pac J Allergy Immunol 2017 Jun 1;

Index
Allergy and Intolerance Abstracts
Cross-React: a new structural bioinformatics method for predicting allergen cross-reactivity.
The phenomenon of cross-reactivity between allergenic proteins plays an important role to understand how the immune system recognizes different antigen proteins. Allergen proteins are known to cross-react if their sequence comparison shows a high sequence identity which also implies that the proteins have a similar 3D fold. In such cases, linear sequence alignment methods are frequently used to predict cross-reactivity between allergenic proteins. However, the prediction of cross-reactivity between distantly related allergens continues to be a challenging task. To overcome this problem, we developed a new structure-based computational method, Cross-React, to predict cross-reactivity between allergenic proteins available in the Structural Database of Allergens (SDAP). Our method is based on the hypothesis that we can find surface patches on 3D structures of potential allergens with amino acid compositions similar to an epitope in a known allergen. We applied the Cross-React method to a diverse set of seven allergens, and successfully identified several cross-reactive allergens with high to moderate sequence identity which have also been experimentally shown to cross-react. Based on these findings, we suggest that Cross-React can be used as a predictive tool to assess protein allergenicity and cross-reactivity. Availability and Implementation: : Cross-React is available at: http://curie.utmb.edu/Cross-React.html. Contact: [email protected]

Cross-React: a new structural bioinformatics method for predicting allergen cross-reactivity.  
Negi SS, Braun W.
Bioinformatics 2017 Apr 1;33(7):1014-1020

Click to view abstract

Index
Allergy and Intolerance Abstracts
Artificial sweeteners and mixture of food additives cause to break oral tolerance and induce food allergy in murine oral tolerance model for food allergy.
The authors hypothesized that food additives prevent acquisition of oral tolerance and aimed to verify the safety of food additives. They induced experimental oral tolerance in mice for ovalbumin (OVA), a food antigen, by previous oral treatment with OVA before sensitization with OVA injections. Food additives were administered at the induction of oral tolerance, and food allergy was induced by repeated administration of OVA. Symptoms of food allergy were defined as a change in body temperature and allergic diarrhoea. Saccharin sodium and a mixture of food additives inhibited acquisition of oral tolerance. Hypothermia and allergic diarrhoea with elevation of OVA-specific IgE were induced in the murine model of oral tolerance. Analyses of antigen-presenting cells in mesenteric lymph nodes showed that food additives affected their manner of migration.

Artificial sweeteners and mixture of food additives cause to break oral tolerance and induce food allergy in murine oral tolerance model for food allergy.  
Yamashita H, Matsuhara H, Miotani S, Sako Y, Matsui T, Tanaka H, Inagaki N.
Clin Exp Allergy 2017 Mar 29;

Click to view abstract

Index
Allergy and Intolerance Abstracts
Anticonvulsant hypersensitivity syndrome after phenytoin administration in an adolescent patient
A 15 year old presented with intermittent high grade fever, jaundice, rash and skin peeling. On examination, she had axillary and inguinal lymphadenopathy, moderate splenomegaly and diffuse maculopapular rash. The patient was on phenytoin which started 1 month prior to her presentation as a seizure prophylaxis due to previous head injury. Eventually, the patient was diagnosed with AHS/DRESS.

Anticonvulsant hypersensitivity syndrome after phenytoin administration in an adolescent patient: a case report and review of literature.  
Ghannam M, Mansour S, Nabulsi A, Abdoh Q.
Clin Mol Allergy 2017;1514

Index
Allergy and Intolerance Abstracts
Systemic allergic dermatitis caused by sesquiterpene lactones.
Patients with Compositae sensitization are routinely warned against the ingestion of vegetables, spices, teas and herbal remedies from this family of plants. The evidence for the occurrence of systemic allergic dermatitis caused by sesquiterpene lactone-containing plants is mostly anecdotal and based on statements from patients rather than scientific data. However, a few clinical reports on accidental sensitization and exposure and oral challenge prove the existence of this kind of reaction, most convincingly for strong contact allergens such as costunolide in bay leaves, and less so for weak allergens such as those of lettuce. Other Compositae species suspected of causing systemic reactions are artichoke, mugwort, yarrow, dandelion, feverfew, and elecampane. Some Compositae vegetables and teas, such as lettuce and chamomile tea, may induce systemic reactions through both humoral and cell-mediated mechanisms. It is difficult to disentangle the contribution of these reactions to both local and systemic symptoms of skin and mucous membranes in, for example, lettuce contact allergy. Further studies are needed to assess the prevalence of systemic allergic dermatitis caused by sesquiterpene lactones, and to clarify the pathogenesis for individual haptens.

Systemic allergic dermatitis caused by sesquiterpene lactones.  
Paulsen E.
Contact Dermatitis 2017 Jan;76(1):1-10

Click to view abstract

Index
Allergy and Intolerance Abstracts
Evaluation of penicillin allergy in the hospitalized patient: opportunities for antimicrobial stewardship.
Penicillin allergy is often misdiagnosed and is associated with adverse consequences, but testing is infrequently done in the hospital setting. This article reviews historical and contemporary innovations in inpatient penicillin allergy testing and its impact on antimicrobial stewardship. Adoption of the electronic medical record allows rapid identification of admitted patients carrying a penicillin allergy diagnosis. Collaboration with clinical pharmacists and the development of computerized clinical guidelines facilitates increased testing and appropriate use of penicillin and related ß-lactams. Education of patients and their outpatient providers is the key to retaining the benefits of penicillin allergy de-labeling. Penicillin allergy testing is feasible in the hospital and offers tangible benefits towards antimicrobial stewardship. Allergists should take the lead in this endeavor and work towards overcoming personnel limitations by partnering with other health care providers and incorporating technology that improves the efficiency of allergy evaluation.

Evaluation of penicillin allergy in the hospitalized patient: opportunities for antimicrobial stewardship.  
Chen JR, Khan DA.
Curr Allergy Asthma Rep 2017 Jun;17(6):40

Index
Allergy and Intolerance Abstracts
Patient-centered outcomes in food allergy.
Advancements have been made in understanding the impact of food allergies on patient-centered outcomes such as quality of life and economic impact, and attempts have been made to develop tools to assess patient-centered variables. Innovative national and regional initiatives are helping to spread awareness of the disease condition and to create resources, including access to allergen-free foods. While there is a growing momentum toward recognition of food allergic disorders as a condition that profoundly impacts activities of daily living, greater effort needs to be expounded to develop validated tools and interventions that can adequately address these issues.

Patient-centered outcomes in food allergy.  
Polk BI, Dinakar C.
Curr Allergy Asthma Rep 2017 Jun;17(6):39

Index
Allergy and Intolerance Abstracts
Molecular aspects of allergens in atopic dermatitis.
Atopic dermatitis, a chronic inflammatory skin disease is almost always associated with IgE sensitization to allergens. However, also non-IgE-mediated pathomechanisms seem to be operative in atopic dermatitis and it is often difficult to identify the disease-causing allergens. Here we review recent work showing the usefulness of molecular allergology to study mechanisms of atopic dermatitis, for diagnosis and eventually for treatment and prevention of atopic dermatitis. IgE sensitization to airborne, food-derived, microbial allergens, and autoallergens has been found to be associated with atopic dermatitis. Using defined allergen molecules and non-IgE-reactive allergen derivatives, evidence could be provided for the existence of IgE- and non-IgE-mediated mechanisms of inflammation in atopic dermatitis. Furthermore, effects of epicutaneous allergen administration on systemic allergen-specific immune responses have been studied. Multi-allergen tests containing micro-arrayed allergen molecules have been shown to be useful for the identification of culprit allergens in atopic dermatitis and may improve the management of atopic dermatitis by allergen-specific immunotherapy, allergen avoidance, and IgE-targeting therapies in a personalized medicine approach.

Molecular aspects of allergens in atopic dermatitis.  
Campana R, Dzoro S, Mittermann I, Fedenko E, Elisyutina O, Khaitov M, Karaulov A, Valenta R.
Curr Opin Allergy Clin Immunol 2017 Jun 15;

Index
Allergy and Intolerance Abstracts
Apheresis in food allergies.
Decreasing IgE becomes a rational approach and could be obtained by immunoapheresis. The aim of this review is to evaluate the rationale and advantages of immunoapheresis. The majority of the available adsorbers remove aspecifically all classes of immunoglobulins. Recently, IgE-specific adsorbers have been approved. Data on immunoapheresis for the treatment of allergic diseases with pathologically elevated IgE levels are emerging. In atopic dermatitis, this therapy alone seems to be beneficial. IgE-selective apheresis appears to be sufficient to reduce the risk of anaphylaxis in multiple food allergy (MFA) and, when IgE titers are high, to open the way to treatment with Omalizumab.

Apheresis in food allergies.  
Dahdah L, Leone G, Artesani M, Riccardi C, Mazzina O.
Curr Opin Allergy Clin Immunol 2017 Jun;17(3):227-231

Index
Allergy and Intolerance Abstracts
Contact allergy cross-reactions: retrospective clinical data and review of the literature.
We discuss cross-reactions that can occur when a patient allergic to a specific allergen also reacts to a similar allergen. Currently, The American Contact Dermatitis Society Contact Allergy Management Program, which allows physicians to identify safe products for their patients, uses a 10% threshold to distinguish significant cross-reactors. New clinical data from a patch testing center along with previous data in the literature are analyzed to help determine whether current cross-reactor definitions are reasonable or should be altered

Contact allergy cross-reactions: retrospective clinical data and review of the literature.  
Scheman A, Hipolito R, Severson D, Youkhanis N.
Dermatitis 2017 Mar;28(2):128-140

Click to view abstract

Index
Allergy and Intolerance Abstracts
Impact of traffic-related air pollution on the expression of Platanus orientalis (Oriental Plane tree) pollen allergens.
Protein and gene expression levels of Pla or 1 and Pla or 3 were considerably greater in pollen samples from highly polluted areas than in pollen from unpolluted areas (p < 0.05). In contrast, no statically significant difference in Pla or 2 protein and mRNA expression level was found between samples from the two areas.

Impact of traffic-related air pollution on the expression of Platanus orientalis pollen allergens.  
Sedghy F, Sankian M, Moghadam M, Ghasemi Z, Mahmoudi M, Varasteh AR.
Int J Biometeorol 2017 Jan;61(1):1-9

Index
Allergy and Intolerance Abstracts
Sensitising effects of genetically modified enzymes used in flavour, fragrance, detergence and pharmaceutical production: cross-sectional study.
Specific IgE antibodies against workplace-specific individual enzymes were measured by the specific fluorescence enzyme-labelled immunoassay in 813 exposed workers seen in cross-sectional surveys. Twenty-three per cent of all exposed workers showed type I sensitisation with IgE antibodies directed against respective workplace-specific enzymes. The highest sensitisation frequencies observed were for workers exposed enzymes derived from alpha-amylase (44%), followed by stainzyme (41%), pancreatinin (35%), savinase (31%), papain (31%), ovozyme (28%), phytase (16%), trypsin (15%) and lipase (4%). The highest individual antibody levels (up to 110 kU/L) were detected in workers exposed to phytase, xylanase and glucanase. In a subgroup comprising 134 workers, detailed clinical diagnostics confirmed work-related symptoms.

Sensitising effects of genetically modified enzymes used in flavour, fragrance, detergence and pharmaceutical production: cross-sectional study.  
Budnik LT, Scheer E, Burge PS, Baur X.
Occup Environ Med 2017 Jan;74(1):39-45

Click to view abstract

Index
Allergy and Intolerance Abstracts
Risk factors for developing food-induced bronchospasm during oral food challenge.
Prevalence of both asthma and food allergy is increasing in Western Europe. In France, according to recent surveys, the prevalence of asthma is 9.4% in children and 7% in adults. Food allergy proven by oral food challenges (OFC) affects between 1 to 10% of the population. Studies have been considering both disorders as comorbidities under the atopic disease concept. Asthmatic children with food allergy have an increased risk for asthma exacerbation and severe asthma, especially when developing anaphylactic reactions. Each part of the respiratory system (the nose, the larynx, and the lungs) may be involved in food-induced allergic reactions, especially in IgE-mediated allergic reactions, and food allergies play a role in the pathogenesis of respiratory tract symptoms.

Risk factors for developing food-induced bronchospasm during oral food challenge.  
Lagreula M, Chiriac AM, Leoni MC, Demoly P, Caimmi D.
Pediatr Allergy Immunol 2017 Jun 20;

Index
Allergy and Intolerance Abstracts
Contact alopecia: improvement of alopecia with discontinuation of fluocinolone oil in individuals allergic to balsam fragrance.
Inflammatory scalp dermatoses can be associated with alopecia, which is nonscarring and reversible in its early stages. This association has been described in seborrheic dermatitis, psoriasis, and atopic dermatitis. We describe three girls with alopecia aggravated by contact allergy to balsam fragrances. All three had complete resolution with avoidance of balsam of Peru and other balsam derivatives (including discontinuation of fluocinolone oil, which contains balsam of pine)

Contact alopecia: improvement of alopecia with discontinuation of fluocinolone oil in individuals allergic to balsam fragrance.  
Admani S, Goldenberg A, Jacob SE.
Pediatr Dermatol 2017 Jan;34(1):e57-e60

Click to view abstract

Index
Allergy and Intolerance Abstracts
Species identification and prevalence of house dust mites as respiratory allergen in kindergartens of the Bandar Abbas City.
The aim of this study was to identify the species and prevalence of house dust mites (HDMs) in kindergartens in Bandar Abbas, south of Iran. 10 kindergartens were selected randomly in five areas of Bandar Abbas. In total, 1758 mites were collected and identified, which consisted of five species: Dermatophagoides pteronyssinus (31.06%), D. evansi (23.49%), D. farinae (17.75%), Ornithonyssus bacoti (19.45%), and Cheyletus malaccensis (8.25%). Two main allergenic dust mite species D. pteronyssinus and D. farinae, coinhabited and were collected from all of kindergartens. Results of this study have revealed that D. pteronyssinus is the most prevalent HDMs in Bandar Abbas Kindergartens and all studied areas are contaminated by more than one dust mite.

Species identification and prevalence of house dust mites as respiratory allergen in kindergartens of the Bandar Abbas City.  
Soleimani-Ahmadi M, Zare M, Abtahi SM, Khazeni A.
Iran J Allergy Asthma Immunol 2017 Apr;16(2):133-139

Index
Allergy and Intolerance Abstracts
Triosephosphate Isomerase and Filamin C share common epitopes as novel allergens of Procambarus clarkii.
Triosephosphate isomerase (TIM) is a key enzyme in glycolysis and has been identified as an allergen in saltwater products. In this study, TIM with a molecular mass of 28 kDa was purified from the freshwater crayfish (Procambarus clarkii) muscle. A 90-kDa protein that showed IgG/IgE cross-reactivity with TIM was purified and identified as filamin C (FLN c), which is an actin-binding protein. TIM showed similar thermal and pH stability with better digestion resistance compared with FLN c. Epitopes of TIM and FLN c demonstrated the sharing of certain residues; the occurrence of common epitopes in the two allergens accounts for their cross-reactivity.

Triosephosphate Isomerase and Filamin C share common epitopes as novel allergens of Procambarus clarkii.  
Yang Y, Zhang YX, Liu M, Maleki SJ, Zhang ML, Liu QM, Cao MJ, Su WJ, Liu GM.
J Agric Food Chem 2017 Feb 1;65(4):950-963

Click to view abstract

Index
Allergy and Intolerance Abstracts
Purification and Characterization of a Black Walnut (Juglans nigra) allergen, Jug n 4.
The purpose of this study was to purify and characterize potential food allergens from black walnut. The authors report the isolation of the black walnuts allergen Jug n 4 (an 11S globulin). 32% of the sera from 25 patients with double-blind, placebo-controlled clinical walnut allergy contained IgE antibodies that recognized Jug n 4, indicating that it is a walnut allergen.

Purification and Characterization of a Black Walnut (Juglans nigra) allergen, Jug n 4.  
Zhang YZ, Du WX, Fan Y, Yi J, Lyu SC, Nadeau KC, Thomas AL, McHugh T.
J Agric Food Chem 2017 Jan 18;65(2):454-462

Click to view abstract

Index
Allergy and Intolerance Abstracts
Allergy testing in predicting outcome of open food challenge to peanut.
This study demonstrates that in the North West of England an Ara h2 peanut component above baseline (>0.4 kUA/L) predicts the outcome of peanut OFC significantly better than either peanut SPT or peanut specific IgE.

Allergy testing in predicting outcome of open food challenge to peanut.  
Rajput S, Sharma V, Hughes SM, Ewing CI, Arkwright PD.
J Allergy Clin Immunol 2017 Jun 14;

Index
Allergy and Intolerance Abstracts
Troponin as a cause of hypersensitivity to barnacle.
A 25-year-old woman experienced anaphylaxis (generalized urticaria, angioedema, and respiratory distress) immediately after ingestion of barnacles. She tolerated bivalves and cephalopods. Skin prick tests were positive for D pteronyssinus, L destructor, T putrescentiae, Ch. arcuatus, shrimp, and B germanica. Prick-by-prick tests with raw and cooked shrimp and barnacle were positive. Iimmunoblotting revealed IgE binding proteins of approximately 17-18 kDa in barnacle extracts (raw, boiled), D pteronyssinus, L destructor, T putrescentiae, Blomia tropicalis, Glyciphagus domesticus, Penaeus indicus, P americana, and Acarus siro, and no IgE reactive bands in the Ch arcuatus extract. The extracts of D pteronyssinus, L destructor, T putrescentiae, B tropicalis, G domesticus, P indicus, P americana, and A siro completely inhibited IgE binding in the barnacle extract. The 17-kDa protein band of barnacle was identified as troponin C. The cross-reactivity detected between the troponin C of the barnacle and mites led to hypothesize that in this case, sensitization by inhalation to troponin C from mite had predisposed the patient to an allergic reaction due to barnacle consumption.

Troponin as a cause of hypersensitivity to barnacle.  
Rial Prado MJ, Batolome B, Pastor C, Cuesta J, Parra A.
J Investig Allergol Clin Immunol 2017 Jun;27(3):194-195

Index

Allergen-, Food allergy-, Intolerance-related articles

Identification of a novel food allergen in lotus root.  
Hiraguchi Y, Tokuda R, Gen M, Shingaki T, Yoshino S, Kumagai Y, Ebishima Y, Hirayama J, Kainuma K, Nagao M, Owa K, Suehiro Y, Fujisawa T.
Allergol Int 2017 Jun 20;

A case of eel collagen allergy.  
Tamura M, Matsui K, Kobayashi Y, Ogita C, Tsuboi K, Kusakabe M, Azuma K, Abe T, Yoshikawa T, Sekiguchi M, Azuma N, Kitano M, Sano H.
Allergol Int 2017 Jun 2;

A prospective microbiome-wide association study of food sensitization and food allergy in early childhood.  
Savage JH, Lee-Sarwar KA, Sordillo J, Bunyavanich S, Zhou Y, O'Connor G, Sandel M, Bacharier L, Zeiger R, Sodergren E, Weinstock GM, Gold DR, Weiss ST, Litonjua AA.
Allergy 2017 Jun 20;

Insights into the global effect of nickel dermatitis on polysensitization.  
Limone BA, Jacob SE.
Ann Allergy Asthma Immunol 2017 Jun;118(6):749

A case of green tea (Camellia sinensis) imbibement causing possible anaphylaxis.  
Wu SS, Johnson JA, Peppers B, Tcheurekdjian H, Hostoffer R.
Ann Allergy Asthma Immunol 2017 Jun;118(6):747-748

Atopic dermatitis and food sensitization in South African toddlers: Role of fiber and gut microbiota.  
Mahdavinia M, Rasmussen HE, Engen P, Van den Berg JP, Davis E, Engen K, Green SJ, Naqib A, Botha M, Gray C, Lunjani N, Hlela C, Basera W, Hobane L, Watkins A, Tobin MC, Landay A, Keshavarzi.
Ann Allergy Asthma Immunol 2017 Jun;118(6):742-743

Hymenoptera venoms used to produce allergen extracts.  
Plunkett G, Jacobson RS, Golden DBK.
Ann Allergy Asthma Immunol 2017 Jun;118(6):649-654

Modifying the infant's diet to prevent food allergy.  
Grimshaw K, Logan K, O'Donovan S, Kiely M, Patient K, van BJ, Beyer K, Campbell DE, Garcia-Larsen V, Grabenhenrich L, Lack G, Mills C, Wal JM, Roberts G.
Arch Dis Child 2017 Feb;102(2):179-186
Click to view abstract

Quantification of Fel d 1 in house dust samples of cat allergic patients by using monoclonal antibody specific to a novel IgE-binding epitope.  
Tasaniyananda N, Tungtrongchitr A, Seesuay W, Sakolvaree Y, Aiumurai P, Indrawattana N, Chaicumpa W, Sookrung N.
Asian Pac J Allergy Immunol 2017 Jun 1;

Drug allergy evaluation for betalactam hypersensitivity: Cross-reactivity with cephalosporines, carbapenems and negative predictive value.  
Al-Ahmad M, Rodriguez-Bouza T.
Asian Pac J Allergy Immunol 2017 Jun 1;

Cross-React: a new structural bioinformatics method for predicting allergen cross-reactivity.  
Negi SS, Braun W.
Bioinformatics 2017 Apr 1;33(7):1014-1020
Click to view abstract

An alternative inhibition method for determining cross-reactive allergens.  
Schmidt-Hieltjes Y, Teodorowicz M, Jansen A, den HG, Elfvering-Berendsen L, de Jong NW, Savelkoul HF, Ruinemans-Koerts J.
Clin Chem Lab Med 2017 Feb 1;55(2):248-253

Artificial sweeteners and mixture of food additives cause to break oral tolerance and induce food allergy in murine oral tolerance model for food allergy.  
Yamashita H, Matsuhara H, Miotani S, Sako Y, Matsui T, Tanaka H, Inagaki N.
Clin Exp Allergy 2017 Mar 29;
Click to view abstract

Mechanisms underlying induction of allergic sensitization by Pru p 3.  
Tordesillas L, Cubells-Baeza N, Gomez-Casado C, Berin C, Esteban V, Barcik W, O'Mahony L, Ramirez C, Pacios LF, Garrido-Arandia M, az-Perales A.
Clin Exp Allergy 2017 Jun 15;

Roadmap for the clinical application of the basophil activation test in food allergy.  
Santos AF, Shreffler WG.
Clin Exp Allergy 2017 Jun 15;

Nut allergy guideline.  
Roberts G.
Clin Exp Allergy 2017 Jun;47(6):708-709

Anticonvulsant hypersensitivity syndrome after phenytoin administration in an adolescent patient: a case report and review of literature.  
Ghannam M, Mansour S, Nabulsi A, Abdoh Q.
Clin Mol Allergy 2017;1514

The impact of penicillin allergy labels on antibiotic and health care use in primary care: a retrospective cohort study.  
Su T, Broekhuizen BDL, Verheij TJM, Rockmann H.
Clin Transl Allergy 2017;718

Presence of allergens in the vehicles of Brazilian dermatological products.  
Rocha VB, Machado CJ, Bittencourt FV.
Contact Dermatitis 2017 Feb;76(2):126-128

Contact allergy trends in Singapore - a retrospective study of patch test data from 2009 to 2013.  
Ochi H, Cheng SW, Leow YH, Goon AT.
Contact Dermatitis 2017 Jan;76(1):49-50

Release of nickel and chromium in common foods during cooking in 18/10 (grade 316) stainless steel pots.  
Guarneri F, Costa C, Cannavo SP, Catania S, Bua GD, Fenga C, Dugo G.
Contact Dermatitis 2017 Jan;76(1):40-48
Click to view abstract

Patch testing with hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) - a multicentre study of the Swedish Contact Dermatitis Research Group.  
Engfeldt M, Hagvall L, Isaksson M, Matura M, Mowitz M, Ryberg K, Stenberg B, Svedman C, Bruze M.
Contact Dermatitis 2017 Jan;76(1):34-39
Click to view abstract

The reactivity of the back revisited. Are there differences in reactivity in different parts of the back?  
Bjork AK, Bruze M, Engfeldt M, Nielsen C, Svedman C.
Contact Dermatitis 2017 Jan;76(1):19-26
Click to view abstract

Systemic allergic dermatitis caused by sesquiterpene lactones.  
Paulsen E.
Contact Dermatitis 2017 Jan;76(1):1-10
Click to view abstract

Effects of long-term exposure to traffic-related air pollution on lung function in children.  
Schultz ES, Litonjua AA, Melen E.
Curr Allergy Asthma Rep 2017 Jun;17(6):41

Evaluation of penicillin allergy in the hospitalized patient: opportunities for antimicrobial stewardship.  
Chen JR, Khan DA.
Curr Allergy Asthma Rep 2017 Jun;17(6):40

Patient-centered outcomes in food allergy.  
Polk BI, Dinakar C.
Curr Allergy Asthma Rep 2017 Jun;17(6):39

Component resolved diagnosis in hymenoptera anaphylaxis.  
Tomsitz D, Brockow K.
Curr Allergy Asthma Rep 2017 Jun;17(6):38

Photodermatitis for the Allergist.  
Coffin SL, Turrentine JE, Cruz PD.
Curr Allergy Asthma Rep 2017 Jun;17(6):36

Food allergy in South Africa.  
Gray CL.
Curr Allergy Asthma Rep 2017 Jun;17(6):35

Reactions to cytostatic agents in children.  
Cernadas JR.
Curr Opin Allergy Clin Immunol 2017 Jun 14;

Molecular aspects of allergens in atopic dermatitis.  
Campana R, Dzoro S, Mittermann I, Fedenko E, Elisyutina O, Khaitov M, Karaulov A, Valenta R.
Curr Opin Allergy Clin Immunol 2017 Jun 15;

Drug allergy/hypersensitivity in adults and children.  
Thong BY, Blanca M.
Curr Opin Allergy Clin Immunol 2017 Jun 8;

Apheresis in food allergies.  
Dahdah L, Leone G, Artesani M, Riccardi C, Mazzina O.
Curr Opin Allergy Clin Immunol 2017 Jun;17(3):227-231

Contact allergy cross-reactions: retrospective clinical data and review of the literature.  
Scheman A, Hipolito R, Severson D, Youkhanis N.
Dermatitis 2017 Mar;28(2):128-140
Click to view abstract

American Contact Dermatitis Society Core Allergen Series: 2017 Update.  
Schalock PC, Dunnick CA, Nedorost S, Brod B, Warshaw E, Mowad C.
Dermatitis 2017 Mar;28(2):141-143
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Anaphylaxis: epidemiology, aetiology and relevance for the clinic.  
Dhami S, Sheikh A.
Expert Rev Clin Immunol 2017 Jun 7;1-7

Assessment of endogenous allergenicity of genetically modified plants exemplified by soybean - Where do we stand?  
Selb R, Wal JM, Moreno FJ, Lovik M, Mills C, Hoffmann-Sommergruber K, Fernandez A.
Food Chem Toxicol 2017 Mar;101139-148
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Modeling pollen time series using seasonal-trend decomposition procedure based on LOESS smoothing.  
Rojo J, Rivero R, Romero-Morte J, Fernandez-Gonzalez F, Perez-Badia R.
Int J Biometeorol 2017 Feb;61(2):335-348

Numerical ragweed pollen forecasts using different source maps: a comparison for France.  
Zink K, Kaufmann P, Petitpierre B, Broennimann O, Guisan A, Gentilini E, Rotach MW.
Int J Biometeorol 2017 Jan;61(1):23-33

Impact of traffic-related air pollution on the expression of Platanus orientalis pollen allergens.  
Sedghy F, Sankian M, Moghadam M, Ghasemi Z, Mahmoudi M, Varasteh AR.
Int J Biometeorol 2017 Jan;61(1):1-9

Sensitising effects of genetically modified enzymes used in flavour, fragrance, detergence and pharmaceutical production: cross-sectional study.  
Budnik LT, Scheer E, Burge PS, Baur X.
Occup Environ Med 2017 Jan;74(1):39-45
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Travelling with food allergy: what to expect from the airlines?  
Padua I, Moreira A, Padrao P, Moreira P, Barros R.
Pediatr Allergy Immunol 2017 Jun 20;

Risk factors for developing food-induced bronchospasm during oral food challenge.  
Lagreula M, Chiriac AM, Leoni MC, Demoly P, Caimmi D.
Pediatr Allergy Immunol 2017 Jun 20;

Contact alopecia: improvement of alopecia with discontinuation of fluocinolone oil in individuals allergic to balsam fragrance.  
Admani S, Goldenberg A, Jacob SE.
Pediatr Dermatol 2017 Jan;34(1):e57-e60
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Angioedema after squaric acid treatment in a 6-year-old girl.  
Chen CA, Carlberg V, Kroshinsky D.
Pediatr Dermatol 2017 Jan;34(1):e44-e46
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Cinnamon sugar scrub dermatitis: 'natural' is not always best.  
Admani S, Hill H, Jacob SE.
Pediatr Dermatol 2017 Jan;34(1):e42-e43
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Learning from the molecular profile of Blattella germanica allergens identified from allergic patients in Tehran, Iran.  
Teifoori F, Postigo I, Martinez J.
Iran J Allergy Asthma Immunol 2017 Apr;16(2):169-170

Species identification and prevalence of house dust mites as respiratory allergen in kindergartens of the Bandar Abbas City.  
Soleimani-Ahmadi M, Zare M, Abtahi SM, Khazeni A.
Iran J Allergy Asthma Immunol 2017 Apr;16(2):133-139

Evaluation of food allergy in children by skin prick tests with commercial extracts and fresh foods, specific IgE and, open oral food challenge-our five years experience in food allergy work-up.  
Zivanovic M, tanaskovic-Markovic M, Medjo B, Gavrovic-Jankulovic M, Smiljanic K, Tmusic V, Djuric V.
Iran J Allergy Asthma Immunol 2017 Apr;16(2):127-132

First-dose anaphylaxis to infliximab: a case of mammalian meat allergy.  
Chitnavis M, Stein DJ, Commins S, Schuyler AJ, Behm B.
J Allergy Clin Immunol Pract 2017 Jun 17;

Anaphylactic shock due to brentuximab-vendotin confirmed by skin test and in vitro tests.  
Noguerado-Mellado B, Rojas-Perez-Ezquerra P, Saenz de Santa Maria Garcia, Rodriguez-Macias G, Tornero P, Bartolome B.
J Allergy Clin Immunol Pract 2017 Jun 17;

Fatal anaphylaxis caused by gadolinium due to beta-tryptase-induced hemorragic diathesis.  
Prieto-Garcia A, Perez-David E, Devesa C, Tornero P, Schwartz LB, Pascual C, Castells MC.
J Allergy Clin Immunol Pract 2017 Jun 17;

Long-term outcomes following baked milk-containing diet for IgE-mediated milk allergy.  
Weinbrand-Goichberg J, Benor S, Rottem M, Shacham N, Mandelberg A, Levine A, Sade K, Kivity S, Dalal I.
J Allergy Clin Immunol Pract 2017 Jun 2;

Analysis of essential oils and fragrances with a new generation of highly inert gas chromatographic columns coated with ionic liquids.  
Cagliero C, Bicchi C, Cordero C, Liberto E, Rubiolo P, Sgorbini B.
J Chromatogr A 2017 Apr 28;149564-75
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Chemical photoallergy: photobiochemical mechanisms, classification, and risk assessments.  
Onoue S, Seto Y, Sato H, Nishida H, Hirota M, Ashikaga T, Api AM, Basketter D, Tokura Y.
J Dermatol Sci 2017 Jan;85(1):4-11
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Development of a strategy for the total chemical synthesis of an allergenic protein: the peach LTP Pru p 3.  
Buhler S, Akkerdaas JH, Pertinhez A, van RR, Dossena A, Sforza S, Tedeschi T.
J Pept Sci 2017 Apr;23(4):282-293
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How proteins aggregate can reduce allergenicity: comparison of ovalbumins heated under opposite electrostatic conditions.  
Claude M, Bouchaud G, Lupi R, Castan L, Tranquet O, ery-Papini S, Bodinier M, Brossard C.
J Agric Food Chem 2017 May 10;65(18):3693-3701
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Allergenicity and oral tolerance of enzymatic cross-linked tropomyosin evaluated using cell and mouse models.  
Liu G, Hu M, Sun LC, Han X, Liu Q, Alcocer M, Fei D, Cao MJ, Liu GM.
J Agric Food Chem 2017 Mar 15;65(10):2205-2213
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Comparison of allergenicity at Gly m 4 and Gly m bd 30k of soybean after genetic modification.  
Tsai JJ, Chang CY, Liao EC.
J Agric Food Chem 2017 Feb 15;65(6):1255-1262
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Triosephosphate Isomerase and Filamin C share common epitopes as novel allergens of Procambarus clarkii.  
Yang Y, Zhang YX, Liu M, Maleki SJ, Zhang ML, Liu QM, Cao MJ, Su WJ, Liu GM.
J Agric Food Chem 2017 Feb 1;65(4):950-963
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Natural variability of allergen levels in conventional soybeans: assessing variation across north and South America from five production Years.  
Geng T, Stojsin D, Liu K, Schaalje B, Postin C, Ward J, Wang Y, Liu ZL, Li B, Glenn K.
J Agric Food Chem 2017 Jan 18;65(2):463-472
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Purification and Characterization of a Black Walnut (Juglans nigra) allergen, Jug n 4.  
Zhang YZ, Du WX, Fan Y, Yi J, Lyu SC, Nadeau KC, Thomas AL, McHugh T.
J Agric Food Chem 2017 Jan 18;65(2):454-462
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Evaluation of structure, chaperone-like activity and allergenicity of reduced glycated adduct of Bovine beta-casein.  
Yousefi R, Ferdowsi L, Tavaf Z, Sadeghian T, Tamaddon AM, Moghtaderi M, Pourpak Z.
Protein Pept Lett 2017;24(1):46-55
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Distribution of peanut protein in school and home environments of inner-city children.  
Sheehan WJ, Brough HA, Makinson K, Petty CR, Lack G, Phipatanakul W.
J Allergy Clin Immunol 2017 Jun 21;

Food protein-induced enterocolitis syndromes with and without bloody stool have distinct clinicopathological features.  
Morita H, Suzuki H, Orihara K, Motomura K, Matsuda A, Ohya Y, Saito H, Nomura I, Matsumoto K.
J Allergy Clin Immunol 2017 Jun 16;

Allergy testing in predicting outcome of open food challenge to peanut.  
Rajput S, Sharma V, Hughes SM, Ewing CI, Arkwright PD.
J Allergy Clin Immunol 2017 Jun 14;

Assessment of thunderstorm-induced asthma using Google Trends.  
Bousquet J, O'Hehir RE, Anto JM, D'Amato G, Mosges R, Hellings PW, Van EM, Sheikh A.
J Allergy Clin Immunol 2017 Jun 1;

A limited survey of dark chocolate bars obtained in the United States for undeclared milk and peanut allergens.  
Bedford B, Yu Y, Wang X, Garber EA, Jackson LS.
J Food Prot 2017 Apr;80(4):692-702
Click to view abstract

Troponin as a cause of hypersensitivity to barnacle.  
Rial Prado MJ, Batolome B, Pastor C, Cuesta J, Parra A.
J Investig Allergol Clin Immunol 2017 Jun;27(3):194-195

Component-resolved diagnosis of dog allergy.  
Basagana M, Luengo O, Labrador M, Garriga T, Mattsson L, Lidholm J, Cardona V.
J Investig Allergol Clin Immunol 2017 Jun;27(3):185-187

First case report of aseptic meningitis induced by adalimumab administered for treatment of chronic plaque psoriasis.  
Wang DY, Chong WS, Pan JY, Heng YK.
J Investig Allergol Clin Immunol 2017 Jun;27(3):183-185

Steps towards clarifying the clinical relevance of minor olive allergens in areas with extremely high levels of olive pollen.  
Alcantara M, Saenz de San PB, Canada C, Munoz MA, Jimeno L, Villalba M, de la TF.
J Investig Allergol Clin Immunol 2017;27(2):138-140


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