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 Allergy Advisor Digest - March 2012
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Read Is food allergy testing reliable in pediatric atopic dermatitis?
Read Subtropical grass pollen allergens are important for allergic respiratory diseases in subtropical regions.
Read Effect of simulated gastro-duodenal digestion on the allergenic reactivity of beta-lactoglobulin.
Read Impact of Aspergillus fumigatus in allergic airway diseases.
Read Not all shellfish "allergy" is allergy!
Read Difference in symptom severity between early and late grass pollen season in patients with seasonal allergic rhinitis.
Read Exhaled nitric oxide decreases after positive food-allergen challenge.
Read Risk of allergic reactions to wine, in milk, egg and fish-allergic patients.
Read Quantification of p-phenylenediamine and 2-hydroxy-1,4-naphthoquinone in henna tattoos.
Read Endemic air-borne contact dermatitis of a rare contact allergy in a waste collection facility.
Read Diagnostic value of specific IgE analysis in latex allergy.
Read Modulation of the Humoral Response to Dermatophagoides pteronyssinus Allergens in BALB/c Mice by Extract Modification and Adjuvant Use.
Read ICON: Food allergy.
Read A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarraundery immunoassay.
Read Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives.
Read Effect of lactose on gut microbiota and metabolome of infants with cow's milk allergy.
Read Cow's milk and ovalbumin-specific IgG and IgA in children with eczema: low beta-lactoglobulin-specific IgG4 levels are associated with cow's milk allergy.
Read The effect of cigarette smoking on allergic conditions in Maltese children (ISAAC).
Read An estimate of the threshold for reacting to a single open application of nickel in nickel-allergic subjects.
Read Are anti-Phl p 12 IgE levels predictive of oral allergy syndrome in profilin hypersensitive patients?
Read Sensitization profiles in polysensitized patients from a restricted geographical area: further lessons from multiplexed component resolved diagnosis.
Read Prevalence of wheat allergy in Japanese adults.
Read Increase in allergen-specific IgE and ex vivo Th2 responses after a single bronchial challenge with house dust mite in allergic asthmatics.
Read A 71-year-old man with anaphylaxis after eating grits (maize).
Read Changes in prevalence and characteristics of IgE-mediated food allergies in children in Texas.
Read Occupational asthma related to low levels of airborne methylene diphenyl diisocyanate (MDI) in orthopedic casting work.
Read IgE reactivity patterns in patients with allergic rhinoconjunctivitis to ragweed and mugwort pollens.
Read Characterization of occupational sensitization by multiallergen immunoblotting in workers exposed to laboratory animals.
Read A case of severe asthma and peach allergy that improved with omalizumab therapy: a case report.

Abstracts shared in March 2012 Advisor Digest Newsletter

Read Anaphylactic reactions to oligosaccharides (alpha-gal) in red meat: a syndrome in evolution.
Read Sensitization to cereals and peanut evidenced by skin prick test and specific IgE in food-tolerant, grass pollen allergic patients.
Read Immediate and delayed allergic hypersensitivity to corticosteroids: practical guidelines.
Read Anisakis simplex recombinant allergens increase diagnosis specificity preserving high sensitivity.
Read Allergenicity and cross-reactivity of booklice: a common household insect pest in Japan.
Read Double positivity to bee and wasp venom: Improved diagnostic procedure by recombinant allergen-based IgE testing and basophil activation test including data about cross-reactive carbohydrate determinants.
Read Increasing the accuracy of peanut allergy diagnosis by using Ara h 2.
Read Allergenicity of Bos d 5 in children with cow's milk allergy is reduced by transglutaminase polymerization.
Read Intake of alcohol and risk of adult-onset asthma.
Read Molecular allergology in practice: an unusual case of LTP allergy.
Read Airborne contact dermatitis to drugs.
Read Poor cross-reactivity between hamster species may influence diagnosis.

Allergy and Intolerance Abstracts
Is food allergy testing reliable in pediatric atopic dermatitis?
The authors sought to assess the value and reliability of serologic testing for predicting clinical food allergy in a population-based cohort of infants with atopic dermatitis (AD). Infants 3-18 months of age, recruited from the general population, were followed quarterly for 3 years and carefully evaluated for evidence of immediate reactions to foods. Specific serum IgE levels for six foods were assayed at 3-5 years. Nine of the 40 patients (23%) who completed 3 years of follow-up had reactions to one or more foods. Reactions occurred in 5, 11 and 18% to milk, peanut and egg ingestion, respectively. In contrast, 30% of food-specific serum IgE tests were above normal. Predictive reliability of tests was generally low unless values were in the high range for peanut and milk. Conversely, egg allergy could be seen across a nearly full-spectrum of IgE values, making prediction highly unreliable. The authors conclude that physician and patient misinterpretation of the relevance and reliability of allergy testing may misdirect proper prevention and therapy of AD.

Is food allergy testing reliable in pediatric atopic dermatitis? A population-based study.  
Keck LE, Simpson EL, Berry TM, Hanifin JM.
Chem Immunol Allergy 2012;96108-112

Index
Allergy and Intolerance Abstracts
Subtropical grass pollen allergens are important for allergic respiratory diseases in subtropical regions.
This article compares allergy to subtropical and temperate grass pollens in patients with allergic rhinitis from a subtropical region of Australia. Sensitization to pollen extracts of the subtropical Bahia grass (Paspalum notatum), Johnson grass (Sorghum halepense) and Bermuda grass (Cynodon dactylon) as well as the temperate Ryegrass (Lolium perenne) were measured by skin prick in 233 subjects from Brisbane. Patients with grass pollen allergy from a subtropical region showed higher skin prick diameters with subtropical Bahia grass and Bermuda grass pollens than with Johnson grass and Ryegrass pollens. IgE reactivity was higher with pollen of Bahia grass than Bermuda grass, Johnson grass and Ryegrass. Patients showed asymmetric cross-inhibition of IgE reactivity with subtropical grass pollens that was not blocked by temperate grass pollen allergens indicating the presence of species-specific IgE binding sites of subtropical grass pollen allergens that are not represented in temperate grass pollens. Subtropical grass pollens are more important allergen sources than temperate grass pollens for patients from a subtropical region. Targeting allergen-specific immunotherapy to subtropical grass pollen allergens in patients with allergic rhinitis in subtropical regions could improve treatment efficacy thereby reducing the burden of allergic rhinitis and asthma.

Subtropical grass pollen allergens are important for allergic respiratory diseases in subtropical regions.  
Davies JM, Li H, Green M, Towers M, Upham JW.
Clin Transl Allergy 2012 Mar 5;2(1):4.

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Allergy and Intolerance Abstracts
Effect of simulated gastro-duodenal digestion on the allergenic reactivity of beta-lactoglobulin.
This study used an in vitro digestion system to investigate the digestibility of ß-lactoglobulin (blg) during gastrointestinal transit and to assess the impact of this process on blg allergenic reactivity in CM allergic children. Blg was only broken down to smaller peptides after gastro-duodenal digestion although a sizeable amount of intact protein still remained. Digestion did not modify the IgE binding capacity of blg except for gastro-duodenal digestion performed in the absence of PC. These results are consistent with the quantity of intact blg remaining in the digesta. Overall both gastric and gastroduodenal digestion enhanced activation of sensitized basophils and proliferation of sensitized lymphocytes by blg. However, there was a tendency towards reduction in mean diameter of SPT following digestion, the PC alone during phase 1 digestion causing a significant increase in mean diameter.

Effect of simulated gastro-duodenal digestion on the allergenic reactivity of beta-lactoglobulin.  
Bossios A, Theodoropoulou M, Mondoulet L, Rigby NM, Papadopoulos NG, Bernard H, Adel-Patient K, Wal JM, Mills CE, Papageorgiou P.
Clin Transl Allergy 2011 Aug 9;1(1):6.

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Allergy and Intolerance Abstracts
Impact of Aspergillus fumigatus in allergic airway diseases.
In contrast to type I-mediated allergies caused by pollen, fungi cause a large number of allergic diseases such as allergic bronchopulmonary mycoses, rhinitis, allergic sinusitis and hypersensitivity pneumonitis. Amongst the fungi, Aspergillus fumigatus is the most prevalent cause of severe pulmonary allergic disease, including allergic bronchopulmonary aspergillosis (ABPA), known to be associated with chronic lung injury and deterioration in pulmonary function in people with chronic asthma and cystic fibrosis (CF). The goal of this review is to discuss new understandings of host-pathogen interactions in the genesis of allergic airway diseases caused by A. fumigatus. Host and pathogen related factors that participate in triggering the inflammatory cycle leading to pulmonary exacerbations in ABPA are discussed.

Impact of Aspergillus fumigatus in allergic airway diseases.  
Chaudhary N, Marr KA.
Clin Transl Allergy 2011 Jun 10;1(1):4.

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Allergy and Intolerance Abstracts
Not all shellfish "allergy" is allergy!
The popularity of shellfish has been increasing worldwide, with a consequent increase in adverse reactions that can be allergic or toxic. The approximate prevalence of shellfish allergy is estimated at 0.5-2.5% of the general population, depending on degree of consumption by age and geographic regions. The manifestations of shellfish allergy vary widely, but it tends to be more severe than most other food allergens.Tropomyosin is the major allergen and is responsible for cross-reactivity between members of the shellfish family, particularly among the crustacea. Newly described allergens and subtle differences in the structures of tropomyosin between different species of shellfish could account for the discrepancy between in vitro cross-antigenicity and clinical cross-allergenicity. The diagnosis requires a thorough medical history supported by skin testing or measurement of specific IgE level, and confirmed by appropriate oral challenge testing unless the reaction was life-threatening.Management of shellfish allergy is basically strict elimination, which in highly allergic subjects may include avoidance of touching or smelling and the availability of self-administered epinephrine. Specific immunotherapy is not currently available and requires the development of safe and effective protocols. Other causes, e.g., Azaspiracids shellfish poisoning, diarrhetic shellfish poisoning, are also discussed.

Not all shellfish "allergy" is allergy!  
Woo CK, Bahna SL.
Clin Transl Allergy 2011 Jun 10;1(1):3.

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Allergy and Intolerance Abstracts
Difference in symptom severity between early and late grass pollen season in patients with seasonal allergic rhinitis.
This study concluded that seasonal allergic rhinitis symptoms at similar grass pollen concentrations are more severe in the early flowering season as compared to those in the late flowering season. This finding is not only relevant for development of forecasts for seasonal allergic rhinitis symptoms but also for understanding symptom development and planning and analysis of clinical studies.

Difference in symptom severity between early and late grass pollen season in patients with seasonal allergic rhinitis.  
de Weger LA, Beerthuizen T, Gast-Strookman JM, van der Plas DT, Terreehorst I, Hiemstra PS, Sont JK.
Clin Transl Allergy 2011 Dec 21;1(1):18.

Index
Allergy and Intolerance Abstracts
Exhaled nitric oxide decreases after positive food-allergen challenge.
These results show a significant decrease in FeNO (exhaled nitric oxide) after a positive food challenge suggesting involvement of the lower airways despite absence of clinical and functional changes of lower airways. Prospective blinded studies are needed to confirm these results.

Exhaled nitric oxide decreases after positive food-allergen challenge.  
Benhamou AH, Koehli A, Rochat I, Inci D, Moeller A, Taramarcaz P, Lauener RP, Eigenmann PA.
Clin Transl Allergy 2011 Nov 28;1(1):14.

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Allergy and Intolerance Abstracts
Risk of allergic reactions to wine, in milk, egg and fish-allergic patients.
European legislators and wine producers still debate on the requirement for labeling of wines fined with potentially allergenic food proteins (casein, egg white or fish-derived isinglass). This study investigated whether wines fined with known concentrations of these proteins have the potential to provoke clinical allergic reactions in relevant patients. In-house wines were produced for the study, fined with different concentrations of casein (n = 7), egg albumin (n = 1) and isinglass (n = 3). Possible reactions to wine was obtained in a multinational cohort of milk, egg or fish allergic patients (n = 53) and patients allergic to irrelevant foods as controls (n = 13). Fining agents were not detectable in wines with the available laboratory methods. Nevertheless, positive skin prick test reactions and basophil activation to the relevant wines were observed in the majority of patients with allergy to milk, egg or fish, correlating with the concentration of the fining agent. Among patients consuming wine, reported reactions were few and mild and similar with the ones reported from the control group. The study concludes that casein, isinglass or egg, remaining in traces in wine after fining, present a very low risk for the respective food allergic consumers.

Risk of allergic reactions to wine, in milk, egg and fish-allergic patients.  
Vassilopoulou E, Karathanos A, Siragakis G, Giavi S, Sinaniotis A, Douladiris N, Fernandez-Rivas M, Clausen M, Papadopoulos NG.
Clin Transl Allergy 2011 Oct 17;1(1):10.

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Allergy and Intolerance Abstracts
Quantification of p-phenylenediamine and 2-hydroxy-1,4-naphthoquinone in henna tattoos.
The aim of this study was to quantify the amounts of lawsone (2-hydroxy-1,4-naphthoquinone, the active ingredient in henna) and p-phenylenediamine (PPD) in products used by tattoo artists and in commercial henna preparations used as hair dyes or to create temporary tattoos. Henna leaves contained 1.85-1.87% lawsone. Only one of the three preparations used by tattoo artists contained lawsone (0.21-0.35%), and all three were adulterated with PPD (1-64%). Of the 11 commercial henna preparations analysed, nine contained lawsone (1-2%) and two contained PPD (2% and 12%). Therefore products purporting to be henna, but that in fact contain no henna, are being offered. Moreover, these products may contain PPD, which is associated with health risks, especially severe allergic reactions.

Quantification of p-phenylenediamine and 2-hydroxy-1,4-naphthoquinone in henna tattoos.  
Almeida PJ, Borrego L, Pulido-Melian E, Gonzalez-Diaz O.
Contact Dermatitis 2012 Jan;66(1):33-37

Click to view abstract

Index
Allergy and Intolerance Abstracts
Endemic air-borne contact dermatitis of a rare contact allergy in a waste collection facility.
Numerous cases of work-related air-borne contact dermatitis of the face were encountered in a waste collection facility. Potential allergens contained in the dust at the facility could be identified. In 5 of 7 symptomatic workers a type-IV sensitization to p-aminodiphenylamine could be documented. Since there is no commercial patch test preparation for p-aminodiphenylamine available, it had to be prepared for each patient individually. (This substance is also found in hair dyes. A patch test is now available. Ed)

Endemic air-borne contact dermatitis? Frequent occurrence of a rare contact allergy in a waste collection facility. [German]  
Skudlik C, Meyer E, Allmers H, Domagalski E, John SM.
Hautarzt 2011 Oct;62(10):765-769

Click to view abstract

Index
Allergy and Intolerance Abstracts
Diagnostic value of specific IgE analysis in latex allergy.
Neither the skin prick test (SPT) nor the latex-specific IgE assay has 100% diagnostic accuracy in latex allergy. The authors assessed the diagnostic value of latex-specific IgE by concomitant use of the SPT and nasal provocation test (NPT). Twenty-seven latex-sensitive patients (group 1), 46 aeroallergen-sensitive patients (group 2a) and 33 healthy subjects (group 2b) participated in the study. Latex-specific IgE was positive in 92.6, 30.4 and 9.1% of groups 1, 2a and 2b, respectively. The 11 aeroallergen-sensitive patients in group 1 and all of the patients in group 2a were predominantly sensitised to pollens (grass, weed and tree) and reacted to a lesser degree to house dust mite, moulds and animal dander. Combined pollinosis was remarkably more prevalent in patients with positive latex-specific IgE in group 2a than in those with negative latex-specific IgE. The NPT was positive in 84.6% of group 1 and negative in all control subjects. The sensitivity, specificity, negative predictive value and positive predictive value of the latex-specific IgE assay were 90.9, 72.2, 96.3 and 50%, respectively. The high rate of false-positive results for latex-specific IgE by ImmunoCAP should be taken into account when making a diagnosis of latex allergy in patients with pollinosis, especially in those sensitised to more than one pollen species.

Diagnostic value of specific ige analysis in latex allergy.  
Unsel M, Mete N, Ardeniz O, Sin A, Gulbahar O, Kokuludag A.
Int Arch Allergy Immunol 2012 Mar 6;158(3):281-287

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Allergy and Intolerance Abstracts
Modulation of the Humoral Response to Dermatophagoides pteronyssinus Allergens in BALB/c Mice by Extract Modification and Adjuvant Use.
These results suggest that the depigmentation and polymerisation process modifies the native extract's antigenic and immunogenic properties and converts the depigmented-polymerised extract into a better choice for allergen-specific immunotherapy

Modulation of the Humoral Response to Dermatophagoides pteronyssinus Allergens in BALB/c Mice by Extract Modification and Adjuvant Use.  
Pico de CY, Carnes J, Gallego MT, Alonso C, Parody N.
Int Arch Allergy Immunol 2012;157(4):331-338

Index
Allergy and Intolerance Abstracts
ICON: Food allergy.
Food allergies can result in life-threatening reactions and diminish quality of life. In the last several decades, the prevalence of food allergies has increased in several regions throughout the world. Although more than 170 foods have been identified as being potentially allergenic, a minority of these foods cause the majority of reactions, and common food allergens vary between geographic regions. Treatment of food allergy involves strict avoidance of the trigger food. Medications manage symptoms of disease, but currently, there is no cure for food allergy. In light of the increasing burden of allergic diseases, the American Academy of Allergy, Asthma & Immunology; European Academy of Allergy and Clinical Immunology; World Allergy Organization; and American College of Allergy, Asthma & Immunology have come together to increase the communication of information about allergies and asthma at a global level. Within the framework of this collaboration, termed the International Collaboration in Asthma, Allergy and Immunology, a series of consensus documents called International Consensus ON (ICON) are being developed to serve as an important resource and support physicians in managing different allergic diseases. An author group was formed to describe the natural history, prevalence, diagnosis, and treatment of food allergies in the context of the global community.

ICON: Food allergy.  
Burks AW, Tang M, Sicherer S, Muraro A, Eigenmann PA, Ebisawa M, Fiocchi A, Chiang W, Beyer K, Wood R, Hourihane J, Jones SM, Lack G, Sampson HA.
J Allergy Clin Immunol 2012 Feb 22;

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Allergy and Intolerance Abstracts
A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarraundery immunoassay.
The complexity and potential of double-blind, placebo-controlled food challenge to cause life-threatening allergic reactions affects its clinical application. A laboratory test that could accurately diagnose symptomatic peanut allergy would greatly facilitate clinical practice. The authors sought to develop an allergy diagnostic method that could correctly predict symptomatic peanut allergy by using peptide microarray immunoassays and bioinformatic methods. Microarray immunoassays were performed by using the sera from 62 patients (31 with symptomatic peanut allergy and 31 who had outgrown their peanut allergy or were sensitized but were clinically tolerant to peanut). Specific IgE and IgG(4) binding to 419 overlapping peptides (15 mers, 3 offset) covering the amino acid sequences of Ara h 1, Ara h 2, and Ara h 3 were measured by using a peptide microarray immunoassay. Individuals with peanut allergy showed significantly greater IgE binding and broader epitope diversity than did peanut-tolerant individuals. No significant difference in IgG(4) binding was found between groups. Four peptide biomarkers were identified and prediction models that can predict the outcome of double-blind, placebo-controlled food challenges with high accuracy were developed by using a combination of the biomarkers.

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarraundery immunoassay.  
Lin J, Bruni FM, Fu Z, Maloney J, Bardina L, Boner AL, Gimenez G, Sampson HA.
J Allergy Clin Immunol 2012 Mar 23;

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Allergy and Intolerance Abstracts
Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives.
The role of diet and of food colors in attention-deficit/hyperactivity disorder (ADHD) or its symptoms warrants updated quantitative meta-analysis, in light of recent divergent policy in Europe and the United States. Studies were identified through a literature search. Twenty-four publications met inclusion criteria for synthetic food colors; 10 additional studies informed analysis of dietary restriction. A random-effects meta-analytic model generated summary effect sizes. Restriction diets reduced ADHD symptoms at an effect of g = 0.29 (95% CI, 0.07-0.53). For food colors, parent reports yielded an effect size of g = 0.18 (95% CI, 0.08-0.24; p = .0007), which decreased to 0.12 (95% CI, 0.01-0.23; p < .05) after adjustment for possible publication bias. The effect was reliable in studies restricted to food color additives (g = 0.21, 95% CI = 0.06-0.36) but did not survive correction for possible publication bias and was not reliable in studies confined to Food and Drug Administration-approved food colors. Teacher/observer reports yielded a nonsignificant effect. However, high-quality studies confined to color additives yielded a reliable effect (g = 0.22, 95% CI = 0.10-0.41, p = .030) that survived correction. In psychometric tests of attention, the summary effect size was 0.27 (95% CI = 0.07-0.47; p = .007) and survived correction. An estimated 8% of children with ADHD may have symptoms related to synthetic food colors. The study concludes that a restriction diet benefits some children with ADHD. Effects of food colors were notable were but susceptible to publication bias or were derived from small, nongeneralizable samples. Renewed investigation of diet and ADHD is warranted.

Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives. J Am Acad Child Adolesc Psychiatry. 2012;51(1):86-97.  
Nigg JT, Lewis K, Edinger T, Falk M.
Miscellaneous

Index
Allergy and Intolerance Abstracts
Effect of lactose on gut microbiota and metabolome of infants with cow's milk allergy.
Allergic infants have an unusual gastrointestinal microbiota with low numbers of Bifidobacterium/Lactobacilli and high levels of Clostridium, staphylococci and Escherichia coli. Hydrolyzed formula used to treat these infants is deprived of lactose that instead may influence the gut microbial composition. The aim of the present study is to investigate the influence of lactose on the composition of the gut microbiota and metabolome of infants with cow's milk allergy. Infants prospectively enrolled received an extensively hydrolyzed formula with no lactose for 2 months followed by an identical lactose-containing formula for an additional 2 months. Healthy, age-gender-matched infants were used as controls. The following determinations were performed before and after the introduction of lactose in the diet: enumeration of cells present in the feces using FISH, counts of viable bacterial cells and gas-chromatography mass spectrometry/solid-phase microextraction analysis. The addition of lactose to the diet significantly increases the counts of Bifidobacteria and lactic acid bacteria (p < 0.01), decreases that of Bacteroides/clostridia (p < 0.05) reaching counts found in healthy controls; lactose significantly increases the concentration of total short-chain fatty acids (p < 0.05). The addition of lactose to an extensively hydrolyzed formula is able to positively modulate the composition of gut microbiota by increasing the total fecal counts of Lactobacillus/Bifidobacteria and decreasing that of Bacteroides/Clostridia. The positive effect is completed by the increase of median concentration of short chain fatty acids, especially for acetic and butyric acids demonstrated by the metabolomic analysis

Effect of lactose on gut microbiota and metabolome of infants with cow's milk allergy.  
Francavilla R, Calasso M, Calace L, Siragusa S, Ndagijimana M, Vernocchi P, Brunetti L, Mancino G, Tedeschi G, Guerzoni E, Indrio F, Laghi L, Miniello VL, Gobbetti M, De AM.
Pediatr Allergy Immunol 2012 Mar 22;

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Allergy and Intolerance Abstracts
Cow's milk and ovalbumin-specific IgG and IgA in children with eczema: low beta-lactoglobulin-specific IgG4 levels are associated with cow's milk allergy.
Tolerance to allergens may partly depend on allergen-specific IgG and IgG subclasses and IgA antibodies. This study investigated whether specific IgG and IgG subclasses and IgA antibodies to beta-lactoglobulin, alpha-casein, and ovalbumin differed between infants who had verified cow's milk allergy (CMA) and infants with cow's milk (CM)-associated eczema, but negative CM oral challenge. The study population comprised 95 infants with clinical eczema that was by history associated with the consumption of CM. After an elimination period, a double-blind, placebo-controlled (DBPC) CM oral challenge confirmed CMA in 45 infants. Skin prick tests (SPT) were performed with CM and hen's egg. Serum levels of IgE antibodies to CM and hen's egg were measured with UniCAP, and levels of IgA, IgG, IgG1, and IgG4 antibodies to beta-lactoglobulin, alpha-casein, and ovalbumin were measured with enzyme-linked immunosorbent assay. Infants with CMA had lower IgG4 levels to beta-lactoglobulin than infants with negative DBPC CM challenge. Positive CM SPT was associated with lower IgG4 levels to alpha-casein. The relation of CM IgE to beta-lactoglobulin and alpha-casein IgG4 was higher in CMA than in infants with negative challenge. Positive egg SPT was associated with elevated levels of specific IgG to ovalbumin, beta-lactoglobulin, and alpha-casein as well as IgA to alpha-casein. This study thus shows that low beta-lactoglobulin-specific serum IgG4 levels may differentiate eczematous infants with CMA from infants who have eczema with only suspected association with CM.

Cow's milk and ovalbumin-specific IgG and IgA in children with eczema: low beta-lactoglobulin-specific IgG4 levels are associated with cow's milk allergy.  
Savilahti EM, Viljanen M, Kuitunen M, Savilahti E.
Pediatr Allergy Immunol 2012 Mar 22;

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Allergy and Intolerance Abstracts
The effect of cigarette smoking on allergic conditions in Maltese children (ISAAC).
This ISAAC study of Maltese children concludes that children smoking more than 10 cigarettes/day persisted with wheezing (p = 0.04) had more frequent episodes of exercise-induced wheeze (p = 0.04), nocturnal cough (p < 0.0001), and rhinoconjunctivitis (p = 0.02) than milder smokers. Smoking seems to be affecting childhood allergies in Maltese children quite significantly.

The effect of cigarette smoking on allergic conditions in Maltese children (ISAAC).  
Montefort S, Ellul P, Montefort M, Caruana S, Grech V, Muscat HA.
Pediatr Allergy Immunol 2012 Mar 22;

Index
Allergy and Intolerance Abstracts
An estimate of the threshold for reacting to a single open application of nickel in nickel-allergic subjects.
This study confirms that nickel levels on the skin in coin handling occupations and some others are sufficient to induce an allergic contact dermatitis in some nickel-allergic subjects. A single application of 5mugcm(-2) when read at 2days induced a dermatitis reaction in six of 21 nickel-allergic subjects.

Nickel skin levels in different occupations and an estimate of the threshold for reacting to a single open application of nickel in nickel-allergic subjects.  
Gawkrodger DJ, McLeod CW, Dobson K.
Br J Dermatol 2012 Jan;166(1):82-87

Click to view abstract

Index
Allergy and Intolerance Abstracts
Are anti-Phl p 12 IgE levels predictive of oral allergy syndrome in profilin hypersensitive patients?
This study investigated whether the levels of profilin IgE are predictive of the development of food allergy in hypersensitive patients. IgE specific for Phl p 12, the grass pollen profilin, were measured in 37 subjects monosensitized to profilin with (n = 11) or without (n = 26) oral allergy syndrome (OAS) following the ingestion of plant-derived foods. Patients without a history of OAS showed higher levels of IgE specific for Phl p 12 than patients with OAS (median 4.74 [range 0.7-41.6] KU/L vs 2.14 [range 0.32-10.2] KU/L, respectively) although the difference did not reach statistical significance (p = 0.07). Therefor factors causing the onset of OAS in profilin-hypersensitive patients remain presently unclear

Are anti-Phl p 12 IgE levels predictive of oral allergy syndrome in profilin hypersensitive patients?  
Asero R, Villalta D.
Eur Ann Allergy Clin Immunol 2011 Dec;43(6):184-187

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Allergy and Intolerance Abstracts
Sensitization profiles in polysensitized patients from a restricted geographical area: further lessons from multiplexed component resolved diagnosis.
The authors studied the sensitisation pattern in a population of polysensitized patients with respiratory allergy, living in a restricted geographical area in the north-west Italy. The 70 patients included had specific IgE towards a mean of 4.3 allergens/patient (range 2-12 allergens). Sixty three (90%) had specific IgE to at least one genuine grass pollen allergen, 32 (45.7%) had Ole e 1 specific IgE antibodies, although olive tree is not present in the area. Sensitisation to mite was found in 47,1%. True co-sensitisation to grass-pollen allergens/Bet v 1/Ole e 1 was observed in 15 individuals (21.4%). Prup 1 was the sensitising allergen in 23 patients (32.9%), 4 of whom were co-sensitised to Prup 3 and/or Art v 3. The authors state that a detailed knowledge of the sensitisation pattern may have relevant implications for the prescription of specific immunotherapy. Moreover, sensitisation to PR-10 (or profilin), frequently associated to oral allergy syndrome, in some cases could hide the sensitisation to LTPs which are clinically more relevant.

Sensitization profiles in polysensitized patients from a restricted geographical area: further lessons from multiplexed component resolved diagnosis.  
Rossi RE, Melioli G, Monasterolo G, Harwanegg C, Rossi L, Canonica GW, Passalacqua G.
Eur Ann Allergy Clin Immunol 2011 Dec;43(6):171-175

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Allergy and Intolerance Abstracts
Prevalence of wheat allergy in Japanese adults.
In this Japanese study, 935 adults were enrolled in a cohort study. A screening was conducted by a questionnaire-based examination and a detection of serum omega-5 gliadin-specific IgE. Subjects who tested positive in the questionnaire-based examination and/or the serum omega-5 gliadin-specific IgE test were further examined by detailed interviews and skin prick tests. A total of 22 subjects were picked up by the screening process, and 17 of these were further examined by secondary testing. Only two subjects were conclusively identified as having wheat allergy. The prevalence of wheat allergy in Japanese adults was found to be 0.21%.

Prevalence of wheat allergy in Japanese adults.  
Morita E, Chinuki Y, Takahashi H, Nabika T, Yamasaki M, Shiwaku K.
Allergol Int 2012 Mar;61(1):101-105

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Allergy and Intolerance Abstracts
Increase in allergen-specific IgE and ex vivo Th2 responses after a single bronchial challenge with house dust mite in allergic asthmatics.
Bronchial allergen challenge is believed to be safe since the allergen-induced effects such as bronchial responses and eosinophilic inflammation return to baseline within a few weeks. The aim of this study was to test the hypothesis that a positive reaction to a single bronchial challenge may enhance an increase in allergen-specific IgE-synthesis and a Th2-cell response to the allergen.

Serum IgE antibodies and Th2/Th1-cell responses to house dust mite were tested before and five weeks after allergen bronchial challenge in mite allergic asthmatics. IgE antibodies to house dust mite extract and the mite allergen components Der p 1 and Der p 2 were significantly (p<0.05) increased (roughly 10%) 5 weeks after a challenge. No significant increase was seen in serum IgE to other sensitizing allergens of the patients. The increase in mite-specific IgE was significantly (p<0.001) associated (r=0.734) with the PC20 methacholine response at baseline. A significant (p<0.001 to p=0.014) increase in Th2-related (IL-4, IL-5, IL13) but not Th1-related cytokines (IL12, INF-g) was shown in mite exposed mononuclear blood cells 5 weeks after challenge.

In conclusion the authors speculate that allergen challenge might reflect the effect of natural exposure and patients with little airway hyper-reactivity are at greatest risk since they will be exposed to highest doses to reach a decrease of 20% in FEV1 during the provocation.

Increase in allergen-specific IgE and ex vivo Th2 responses after a single bronchial challenge with house dust mite in allergic asthmatics.  
van de Pol MA, Lutter R, van RR, van der Zee JS.
Allergy 2011 Sep 29;

Index
Allergy and Intolerance Abstracts
A 71-year-old man with anaphylaxis after eating grits (maize).
A 71-year-old man with no history of food allergy or atopy presented to the emergency room after suffering anaphylaxis after a meal of grits and shrimp. The underlying diagnosis requires a high index of suspicion and should be included in the differential diagnosis of any patient presenting with unexplained anaphylaxis.

A 71-year-old man with anaphylaxis after eating grits.  
Posthumus J, Borish L.
Allergy Asthma Proc 2012 Jan;33(1):110-113

Index
Allergy and Intolerance Abstracts
Changes in prevalence and characteristics of IgE-mediated food allergies in children in Texas.
This study was performed to determine the trends in prevalence and clinical characteristics of physician-diagnosed pediatric food allergy (FA) at a large urban-based tertiary care center in Texas from 2003 to 2008. Patients with allergies to cow's milk, eggs, fish, peanuts, sesame, shellfish, soy, tree nuts, and wheat were included. The percentage of FA clinic patients increased from 3 to 8% over 5 years. The severity of initial reactions to food also increased from 2003 to 2008 (p < 0.05). Mean initial food-specific IgE decreased from 52 kU/L in 2003 to 40 kU/L in 2003. The age at diagnosis decreased from 2003 to 2008 for cow's milk (2.64-1.36 years) and fish (5.10-2.86 years) allergies. Peanuts and shellfish were associated with anaphylaxis and severe symptoms in 2008.

Changes in prevalence and characteristics of IgE-mediated food allergies in children referred to a tertiary care center in 2003 and 2008.  
Amin AJ, Davis CM.
Allergy Asthma Proc 2012 Jan;33(1):95-101

Index
Allergy and Intolerance Abstracts
Occupational asthma related to low levels of airborne methylene diphenyl diisocyanate (MDI) in orthopedic casting work.
A report on two occupational asthma cases due to methylene diphenyl diisocyanate (MDI) in nurses irregularly applying orthopedic plaster casts, verified with placebo controlled specific inhalation challenge. The levels of MDI in the air were measuredand the concentrations were well below the occupational exposure limit in both specific inhalation challenge and hospital measurements. Based on these findings, even minor exposure to airborne MDI in casting work can cause an asthmatic reaction in some patients.

Occupational asthma related to low levels of airborne methylene diphenyl diisocyanate (MDI) in orthopedic casting work.  
Suojalehto H, Linstrom I, Henriks-Eckerman ML, Jungewelter S, Suuronen K.
Am J Ind Med 2011 Dec;54(12):906-910

Click to view abstract

Index
Allergy and Intolerance Abstracts
IgE reactivity patterns in patients with allergic rhinoconjunctivitis to ragweed and mugwort pollens.
Differential diagnosis between ragweed and mugwort pollen allergy represents a large clinical problem in areas where both plants are present. The aim of this study was to investigate ragweed- and mugwort-sensitized patients to identify specific IgE reactivity profiles. Seventy-four patients with allergic rhinoconjunctivitis between July and October were examined. Seventy-one patients revealed positive SPT reactivity against mugwort and 60 patients against ragweed extracts. Of these patients, 74 revealed IgE antibodies against mugwort extracts, whereas anti-Art v 1 antibodies were detectable in 50 individuals. Fifty-five patients showed IgE antibodies against natural ragweed extracts; anti-Amb v 1 antibodies were detected in six cases only. Using standardized clinical history and HRQL questionnaires we were not able to detect any differences within different reactivity patterns. The study concludes that within the investigated population of 74 weed-allergic patients the prevalence of true mugwort and ragweed sensitization was calculated as 68 and 8%. High prevalence of ragweed sensitization when testing with full extracts can be explained by cross-reactivity between other weeds, e.g., mugwort rather than cosensitization.

IgE reactivity patterns in patients with allergic rhinoconjunctivitis to ragweed and mugwort pollens.  
Canis M, Becker S, Groger M, Kramer MF.
Am J Rhinol Allergy 2012 Jan;26(1):31-35

Index
Allergy and Intolerance Abstracts
Characterization of occupational sensitization by multiallergen immunoblotting in workers exposed to laboratory animals.
Studies have estimated that 10% to 23% of workers exposed to laboratory animals report symptoms of laboratory animal allergy. This study's aim was to determine the level of occupational sensitization in workers exposed to laboratory animals and to develop a diagnosis system based on a multiallergen IgE immunoblot. A total of 75 workers exposed to laboratory animals were initially studied with skin prick tests performed with animal epithelia extracts. The workers with suspected occupational disease and positive skin prick test results were further studied with the ImmunoCAP system to determine specific IgE levels to urine and epithelia allergens and with multiallergen IgE immunoblotting to detect specific IgE levels to epithelia allergens and bovine serum albumin. Twenty of the 75 workers were studied with ImmunoCAP and multiallergen IgE immunoblotting. Nine were polysensitized and 3 were sensitized to only one animal. The results obtained by ImmunoCAP and multiallergen IgE immunoblotting were concordant except for in 3 workers, who had low or negative values of specific IgE determined by ImmunoCAP but positive allergen detections by immunoblotting. On the basis of the results of the study and the clinical symptoms related by workers, 16% were diagnosed as having occupational allergy. Therefore multiallergen immunoblotting by means of a unique test offers a graphic representation of sensitization to the different animals to which workers are exposed, providing additional information on the clinical symptoms caused by the involved allergens. The results presented suggest that this system can improve the diagnosis of laboratory animal allergy by obtaining a sensitization profile for each exposed worker

Characterization of occupational sensitization by multiallergen immunoblotting in workers exposed to laboratory animals.  
Caballero ML, Ordaz E, Bermejo M, Rodriguez-Perez R, Alday E, Maqueda J, Moneo I.
Ann Allergy Asthma Immunol 2012 Mar;108(3):178-181

Index
Allergy and Intolerance Abstracts
A case of severe asthma and peach allergy that improved with omalizumab therapy: a case report.
A 30-year-old woman with refractory asthma also experienced severe anaphylaxic episodes after ingesting peaches. Skin and serologic testing confirmed severe allergy to house dust, mites and peaches. Ingesting 6.5 g of peach induced dyspnea. Her asthma could not be controlled despite a leukotriene receptor antagonist and combination inhalation of high-dose salmeterol xinafoate/fluticasone propionate. Treatment with omalizumab (150 mg, once a month) to ensure asthma control was initiated. The asthmatic symptoms ameliorated. The restriction on peach consumption was lifted and a challenge showed tolerance of 290 mg of peach at 28 weeks after starting omalizumab therapy. The patient subsequently did not experience allergic symptoms on ingesting peaches. Thus, in this patient, omalizumab therapy was highly effective in achieving remission from both asthma and peach allergy.

A case of severe asthma and peach allergy that improved with omalizumab therapy: a case report. [Japanese]  
Suzuki S, Matsuura T, Kimura T, Tazaki T, Fukuda M, Homma T, Matsukura S, Kurokawa M, Adachi M.
Arerugi 2012 Feb;61(2):215-223

Index

Allergen-, Food allergy-, Intolerance-related articles

Purified Timothy grass pollen major allergen Phl p 1 may contribute to the modulation of allergic responses through a pleiotropic induction of cytokines and chemokines from airway epithelial cells.  
Roschmann KI, van Kuijen AM, Luiten S, Jonker MJ, Breit TM, Fokkens WJ, Petersen A, van Drunen CM.
Clin Exp Immunol 2012 Mar;167(3):413-421
Click to view abstract

Serine protease Per a 10 from Periplaneta americana bias dendritic cells towards type 2 by upregulating CD86 and low IL-12 secretions.  
Goel C, Govindaraj D, Singh BP, Farooque A, Kalra N, Arora N.
Clin Exp Allergy 2012 Mar;42(3):412-422

Is food allergy testing reliable in pediatric atopic dermatitis? A population-based study.  
Keck LE, Simpson EL, Berry TM, Hanifin JM.
Chem Immunol Allergy 2012;96108-112

Can microbial superantigens influence atopic dermatitis flares?  
Alomar A.
Chem Immunol Allergy 2012;9673-76

What can dogs bring to atopic dermatitis research?  
Olivry T.
Chem Immunol Allergy 2012;9661-72

Mechanisms of immune tolerance to allergens.  
Fujita H, Meyer N, Akdis M, Akdis CA.
Chem Immunol Allergy 2012;9630-38

Anaphylactic reactions to oligosaccharides in red meat: a syndrome in evolution.  
Saleh H, Embry S, Nauli A, Atyia S, Krishnaswamy G.
Clin Mol Allergy 2012 Mar 7;10(1):5

Subtropical grass pollen allergens are important for allergic respiratory diseases in subtropical regions.  
Davies JM, Li H, Green M, Towers M, Upham JW.
Clin Transl Allergy 2012 Mar 5;2(1):4.

Effect of simulated gastro-duodenal digestion on the allergenic reactivity of beta-lactoglobulin.  
Bossios A, Theodoropoulou M, Mondoulet L, Rigby NM, Papadopoulos NG, Bernard H, Adel-Patient K, Wal JM, Mills CE, Papageorgiou P.
Clin Transl Allergy 2011 Aug 9;1(1):6.

Impact of Aspergillus fumigatus in allergic airway diseases.  
Chaudhary N, Marr KA.
Clin Transl Allergy 2011 Jun 10;1(1):4.

Not all shellfish "allergy" is allergy!  
Woo CK, Bahna SL.
Clin Transl Allergy 2011 Jun 10;1(1):3.

Difference in symptom severity between early and late grass pollen season in patients with seasonal allergic rhinitis.  
de Weger LA, Beerthuizen T, Gast-Strookman JM, van der Plas DT, Terreehorst I, Hiemstra PS, Sont JK.
Clin Transl Allergy 2011 Dec 21;1(1):18.

Repeated allergen exposure reduce early phase airway response and leukotriene release despite upregulation of 5-lipoxygenase pathways.  
Cui ZH, Radinger M, Sjostrand M, Lotvall J.
Clin Transl Allergy 2012 Mar 22;2(1):7.

Sensitization to cereals and peanut evidenced by skin prick test and specific IgE in food-tolerant, grass pollen allergic patients.  
Martens M, Schnoor HJ, Malling HJ, Poulsen LK.
Clin Transl Allergy 2011 Dec 9;1(1):15.

Exhaled nitric oxide decreases after positive food-allergen challenge.  
Benhamou AH, Koehli A, Rochat I, Inci D, Moeller A, Taramarcaz P, Lauener RP, Eigenmann PA.
Clin Transl Allergy 2011 Nov 28;1(1):14.

Risk of allergic reactions to wine, in milk, egg and fish-allergic patients.  
Vassilopoulou E, Karathanos A, Siragakis G, Giavi S, Sinaniotis A, Douladiris N, Fernandez-Rivas M, Clausen M, Papadopoulos NG.
Clin Transl Allergy 2011 Oct 17;1(1):10.

Allergic contact dermatitis caused by a skin-lightening agent, 5,5'-dipropylbiphenyl-2,2'-diol.  
Suzuki K, Yagami A, Matsunaga K.
Contact Dermatitis 2012 Jan;66(1):51-52

Occupational contact urticaria caused by polyvinylchloride gloves.  
Sasseville D, Theriault M.
Contact Dermatitis 2012 Jan;66(1):49-50

Positive patch test reaction to Lonicera japonica extract in a patient sensitized to formaldehyde.  
Gallo R, Paolino S, Salis A, Cinotti E, Parodi A.
Contact Dermatitis 2012 Jan;66(1):47-49

Case report: allergic contact cheilitis caused by ceresin wax.  
Powell M, Moreau L.
Contact Dermatitis 2012 Jan;66(1):46-47

Allergic complications from orthopaedic joint implants: the role of delayed hypersensitivity to benzoyl peroxide in bone cement.  
Bircher A, Friederich NF, Seelig W, Scherer K.
Contact Dermatitis 2012 Jan;66(1):20-26
Click to view abstract

p-Phenylenediamine and other hair dye sensitizers in Spain.  
Yazar K, Boman A, Liden C.
Contact Dermatitis 2012 Jan;66(1):27-32
Click to view abstract

Immediate and delayed allergic hypersensitivity to corticosteroids: practical guidelines.  
Baeck M, Goossens A.
Contact Dermatitis 2012 Jan;66(1):38-45
Click to view abstract

Quantification of p-phenylenediamine and 2-hydroxy-1,4-naphthoquinone in henna tattoos.  
Almeida PJ, Borrego L, Pulido-Melian E, Gonzalez-Diaz O.
Contact Dermatitis 2012 Jan;66(1):33-37
Click to view abstract

Hypersensitivity reactions to metallic implants - diagnostic algorithm and suggested patch test series for clinical use.  
Schalock PC, Menne T, Johansen JD, Taylor JS, Maibach HI, Liden C, Bruze M, Thyssen JP.
Contact Dermatitis 2012 Jan;66(1):4-19
Click to view abstract

Contact dermatitis. Allergology must show its expertise. [German]  
John SM, Werfel T.
Hautarzt 2011 Oct;62(10):731

Allergic contact dermatitis and atopy. [German]  
Niebuhr M, Kapp A, Werfel T, Heratizadeh A.
Hautarzt 2011 Oct;62(10):744-750
Click to view abstract

Genetics of contact allergy. [German]  
Schnuch A.
Hautarzt 2011 Oct;62(10):732-738
Click to view abstract

Current contact allergens. [German]  
Geier J, Uter W, Lessmann H, Schnuch A.
Hautarzt 2011 Oct;62(10):751-756
Click to view abstract

Endemic air-borne contact dermatitis? Frequent occurrence of a rare contact allergy in a waste collection facility. [German]  
Skudlik C, Meyer E, Allmers H, Domagalski E, John SM.
Hautarzt 2011 Oct;62(10):765-769
Click to view abstract

Farmer's Lung in a Case after Bullectomy.  
Koschel D, Holfert J, Rolle A, Holotiuk O, Hoffken G.
Int Arch Allergy Immunol 2012 Mar 6;158(3):313-316

Drug Allergy in Hospitalized Patients: The Contribution of Allergy Consultation and a Structured Questionnaire.  
Confino-Cohen R, Leader A, Klein N, Pereg D, Khoury S, Perl L, Goldberg A.
Int Arch Allergy Immunol 2012 Mar 6;158(3):307-312

Atopy Is Inversely Related to Schistosome Infection Intensity: A Comparative Study in Zimbabwean Villages with Distinct Levels of Schistosoma haematobium Infection.  
Rujeni N, Nausch N, Bourke CD, Midzi N, Mduluza T, Taylor DW, Mutapi F.
Int Arch Allergy Immunol 2012 Mar 6;158(3):288-298

Diagnostic value of specific ige analysis in latex allergy.  
Unsel M, Mete N, Ardeniz O, Sin A, Gulbahar O, Kokuludag A.
Int Arch Allergy Immunol 2012 Mar 6;158(3):281-287

Early life interventions to prevent allergy in the offspring: the role of maternal immunization and postnatal mucosal allergen exposure.  
Hansen JS, Nygaard UC, Lyle R, Lovik M.
Int Arch Allergy Immunol 2012 Mar 2;158(3):261-275

Estrogen stimulates th2 cytokine production and regulates the compartmentalisation of eosinophils during allergen challenge in a mouse model of asthma.  
Cai Y, Zhou J, Webb DC.
Int Arch Allergy Immunol 2012 Mar 2;158(3):252-260

Anisakis simplex recombinant allergens increase diagnosis specificity preserving high sensitivity.  
Caballero ML, Umpierrez A, Perez-Pinar T, Moneo I, de BC, Asturias JA, Rodriguez-Perez R.
Int Arch Allergy Immunol 2012 Mar 2;158(3):232-240

Allergenicity and cross-reactivity of booklice (Liposcelis bostrichophila): a common household insect pest in Japan.  
Fukutomi Y, Kawakami Y, Taniguchi M, Saito A, Fukuda A, Yasueda H, Nakazawa T, Hasegawa M, Nakamura H, Akiyama K.
Int Arch Allergy Immunol 2012;157(4):339-348

Modulation of the Humoral Response to Dermatophagoides pteronyssinus Allergens in BALB/c Mice by Extract Modification and Adjuvant Use.  
Pico de CY, Carnes J, Gallego MT, Alonso C, Parody N.
Int Arch Allergy Immunol 2012;157(4):331-338

Skin prick testing to aeroallergen extracts: what is the optimal panel in children and adolescents in Turkey?  
Sahiner UM, Civelek E, Yavuz ST, Buyuktiryaki AB, Tuncer A, Sekerel BE.
Int Arch Allergy Immunol 2012;157(4):391-398

Validation of a phage display and computational algorithm by mapping a conformational epitope of Bla g 2.  
Tiwari R, Negi SS, Braun B, Braun W, Pomes A, Chapman MD, Goldblum RM, Midoro-Horiuti T.
Int Arch Allergy Immunol 2012;157(4):323-330

Cow's milk anaphylaxis in children first report of Iranian food allergy registry.  
Teymourpour P, Pourpak Z, Fazlollahi MR, Barzegar S, Shokouhi R, Akramian R, Movahedi M, Mansouri M, Mirsaeedghazi B, Moin M.
Iran J Allergy Asthma Immunol 2012 Mar;11(1):29-36

Positive patch test reactions in older individuals: retrospective analysis from the North American Contact Dermatitis Group, 1994-2008.  
Warshaw EM, Raju SI, Fowler JF, Maibach HI, Belsito DV, Zug KA, Rietschel RL, Taylor JS, Mathias CG, Fransway AF, DeLeo VA, Marks JG, Storrs FJ, Pratt MD, Sasseville D.
J Am Acad Dermatol 2012 Feb;66(2):229-240
Click to view abstract

Double positivity to bee and wasp venom: Improved diagnostic procedure by recombinant allergen-based IgE testing and basophil activation test including data about cross-reactive carbohydrate determinants.  
Eberlein B, Krischan L, Darsow U, Ollert M, Ring J.
J Allergy Clin Immunol 2012 Mar 14;

Reduced expression of the prostaglandin E(2) receptor E-prostanoid 2 on bronchial mucosal leukocytes in patients with aspirin-sensitive asthma.  
Corrigan CJ, Napoli RL, Meng Q, Fang C, Wu H, Tochiki K, Reay V, Lee TH, Ying S.
J Allergy Clin Immunol 2012 Mar 12;

ICON: Food allergy.  
Burks AW, Tang M, Sicherer S, Muraro A, Eigenmann PA, Ebisawa M, Fiocchi A, Chiang W, Beyer K, Wood R, Hourihane J, Jones SM, Lack G, Sampson HA.
J Allergy Clin Immunol 2012 Feb 22;

Effect of precautionary statements on the purchasing practices of Canadians directly and indirectly affected by food allergies.  
Ben-Shoshan M, Sheth S, Harrington D, Soller L, Fragapane J, Joseph L, St PY, La VS, Elliott S, Waserman S, Alizadehfar R, Harada L, Allen M, Allen MH, Clarke AE.
J Allergy Clin Immunol 2012 Mar 14;

A bioinformatics approach to identify patients with symptomatic peanut allergy using peptide microarraundery immunoassay.  
Lin J, Bruni FM, Fu Z, Maloney J, Bardina L, Boner AL, Gimenez G, Sampson HA.
J Allergy Clin Immunol 2012 Mar 23;

Pulmonary alveolar proteinosis in patients with adenosine deaminase deficiency.  
Grunebaum E, Cutz E, Roifman CM.
J Allergy Clin Immunol 2012 Mar 10;

Oral food challenges in a practice setting apart from hospitals and academic centers.  
Bock SA, Cherrington L.
J Allergy Clin Immunol 2012 Mar 10;

House dust bioactivities predict skin prick test reactivity for children with high risk of allergy.  
Kim H, Tse K, Levin L, Bernstein D, Reponen T, Lemasters G, Lummus Z, Horner AA.
J Allergy Clin Immunol 2012 Feb 29;

Increasing the accuracy of peanut allergy diagnosis by using Ara h 2.  
Dang TD, Tang M, Choo S, Licciardi PV, Koplin JJ, Martin PE, Tan T, Gurrin LC, Ponsonby AL, Tey D, Robinson M, Dharmage SC, Allen KJ.
J Allergy Clin Immunol 2012 Feb 29;

Decreased expression of acetaminophen-metabolizing enzymes and glutathione in asthmatic children after acetaminophen exposure.  
Stephenson ST, Hadley G, Brown LA, Fitzpatrick AM.
J Allergy Clin Immunol 2012 Mar;129(3):867-869

Daily vacuuming of mattresses significantly reduces house dust mite allergens, bacterial endotoxin, and fungal beta-glucan.  
Wu FF, Wu MW, Pierse N, Crane J, Siebers R.
J Asthma 2012 Mar;49(2):139-143

Meta-analysis of attention-deficit/hyperactivity disorder or attention-deficit/hyperactivity disorder symptoms, restriction diet, and synthetic food color additives. J Am Acad Child Adolesc Psychiatry. 2012;51(1):86-97.  
Nigg JT, Lewis K, Edinger T, Falk M.
Miscellaneous

Vemurafenib sensitivity skin reaction after ipilimumab.  
Harding JJ, Pulitzer M, Chapman PB.
N Engl J Med 2012 Mar 1;366(9):866-868

A prediction rule for food challenge outcome in children.  
Zomer-Kooijker K, Slieker MG, Kentie PA, van der Ent CK, Meijer Y.
Pediatr Allergy Immunol 2012 Feb 23;

Cost-effectiveness of using an extensively hydrolysed formula compared to an amino acid formula as first-line treatment for cow milk allergy in the UK.  
Taylor RR, Sladkevicius E, Panca M, Lack G, Guest JF.
Pediatr Allergy Immunol 2012 Feb 23;

Effect of endotoxin and allergens on neonatal lung function and infancy respiratory symptoms and eczema.  
bbing-Karahagopian V, van der Gugten AC, van der Ent CK, Uiterwaal C, de JM, Oldenwening M, Brunekreef B, Gehring U.
Pediatr Allergy Immunol 2012 Mar 22;

Unraveling the relationship between aeroallergen sensitization, gender, second-hand smoke exposure, and impaired lung function.  
Brunst KJ, Ryan PH, Lockey JE, Bernstein DI, McKay RT, Khurana Hershey GK, Villareal M, Biagini Myers JM, Levin L, Burkle J, Evans S, Lemasters GK.
Pediatr Allergy Immunol 2012 Mar 22;

Effect of lactose on gut microbiota and metabolome of infants with cow's milk allergy.  
Francavilla R, Calasso M, Calace L, Siragusa S, Ndagijimana M, Vernocchi P, Brunetti L, Mancino G, Tedeschi G, Guerzoni E, Indrio F, Laghi L, Miniello VL, Gobbetti M, De AM.
Pediatr Allergy Immunol 2012 Mar 22;

Cow's milk and ovalbumin-specific IgG and IgA in children with eczema: low beta-lactoglobulin-specific IgG4 levels are associated with cow's milk allergy.  
Savilahti EM, Viljanen M, Kuitunen M, Savilahti E.
Pediatr Allergy Immunol 2012 Mar 22;

The effect of cigarette smoking on allergic conditions in Maltese children (ISAAC).  
Montefort S, Ellul P, Montefort M, Caruana S, Grech V, Muscat HA.
Pediatr Allergy Immunol 2012 Mar 22;

Practical dietary management of protein energy malnutrition in young children with cow's milk protein allergy.  
Meyer R, Venter C, Fox AT, Shah N.
Pediatr Allergy Immunol 2012 Mar 22;

Tree nut introduction in peanut allergic children is not without risk.  
Stiefel G, Keeton D, Morenas R, Roberts G, Lucas JS, Erlewyn-Lajeunesse M.
Pediatr Allergy Immunol 2012 Mar;23(2):205-206

Intake of alcohol and risk of adult-onset asthma.  
Lieberoth S, Backer V, Kyvik KO, Skadhauge LR, Tolstrup JS, Gronbaek M, Linneberg A, Thomsen SF.
Respir Med 2012 Feb;106(2):184-188
Click to view abstract

Health effects of a subway environment in mild asthmatic volunteers.  
Klepczynska-Nystrom A, Larsson BM, Grunewald J, Pousette C, Lundin A, Eklund A, Svartengren M.
Respir Med 2012 Jan;106(1):25-33
Click to view abstract

Nickel skin levels in different occupations and an estimate of the threshold for reacting to a single open application of nickel in nickel-allergic subjects.  
Gawkrodger DJ, McLeod CW, Dobson K.
Br J Dermatol 2012 Jan;166(1):82-87
Click to view abstract

Is drug allergy less prevalent than previously assumed? A 5-year analysis.  
Heinzerling LM, Tomsitz D, Anliker MD.
Br J Dermatol 2012 Jan;166(1):107-114
Click to view abstract

Transfer of IgE-mediated hypersensitivity with autologous stem cell transplantation.  
Sanchez-Borges M, Goldsztajn HJ.
Eur Ann Allergy Clin Immunol 2011 Dec;43(6):196-198

Molecular allergology in practice: an unusual case of LTP allergy.  
Metz-Favre C, Pauli G, Bessot JC, De BF.
Eur Ann Allergy Clin Immunol 2011 Dec;43(6):193-195

Are anti-Phl p 12 IgE levels predictive of oral allergy syndrome in profilin hypersensitive patients?  
Asero R, Villalta D.
Eur Ann Allergy Clin Immunol 2011 Dec;43(6):184-187

Sensitization profiles in polysensitized patients from a restricted geographical area: further lessons from multiplexed component resolved diagnosis.  
Rossi RE, Melioli G, Monasterolo G, Harwanegg C, Rossi L, Canonica GW, Passalacqua G.
Eur Ann Allergy Clin Immunol 2011 Dec;43(6):171-175

Airborne contact dermatitis to drugs.  
Minciullo PL, Imbesi S, Tigano V, Gangemi S.
Allergol Immunopathol (Madr ) 2012 Mar 23;

New pets, new allergies.  
Marenco-Arellano V, Bartolome B, Reano-Martos M, Marrero C, Rodriguez-Cabreros M, Iglesias-Cadarso A.
Allergol Immunopathol (Madr ) 2012 Mar;40(2):128-129

Cefotaxim induced a near fatal anaphylactic shock in an infant.  
Moreno-Ancillo A, Gil-Adrados AC.
Allergol Immunopathol (Madr ) 2012 Mar;40(2):125-126

Prophylactic probiotics reduce cow's milk protein intolerance in neonates after small intestine surgery and antibiotic treatment presenting symptoms that mimics postoperative infection.  
Ezaki S, Itoh K, Kunikata T, Suzuki K, Sobajima H, Tamura M.
Allergol Int 2012 Mar;61(1):107-113

Prevalence of wheat allergy in Japanese adults.  
Morita E, Chinuki Y, Takahashi H, Nabika T, Yamasaki M, Shiwaku K.
Allergol Int 2012 Mar;61(1):101-105

The definitive diagnostic process and successful treatment for ABPM caused by Schizophyllum commune: a report of two cases.  
Ogawa H, Fujimura M, Takeuchi Y, Makimura K, Satoh K.
Allergol Int 2012 Mar;61(1):163-169

Dissecting the causes of atopic dermatitis in children: less foods, more mites.  
Fuiano N, Incorvaia C.
Allergol Int 2012 Feb 25;0(0):

Increase in allergen-specific IgE and ex vivo Th2 responses after a single bronchial challenge with house dust mite in allergic asthmatics.  
van de Pol MA, Lutter R, van RR, van der Zee JS.
Allergy 2011 Sep 29;

Pholcodine in cough medicines and IgE-sensitization in the EU: an urgent task.  
Florvaag E, Johansson SG.
Allergy 2012 Mar 2;

Practical guide to skin prick tests in allergy to aeroallergens: some concerns.  
Sekerel BE, Sahiner UM, Bousquet J, Demoly P, Zuberbier T, Carlsen KH, Wickman M.
Allergy 2012 Mar;67(3):442

A 71-year-old man with anaphylaxis after eating grits.  
Posthumus J, Borish L.
Allergy Asthma Proc 2012 Jan;33(1):110-113

Changes in prevalence and characteristics of IgE-mediated food allergies in children referred to a tertiary care center in 2003 and 2008.  
Amin AJ, Davis CM.
Allergy Asthma Proc 2012 Jan;33(1):95-101

No systemic reactions to influenza vaccination in egg-sensitized tertiary-care pediatric patients.  
Upton JE, Hummel DB, Kasprzak A, Atkinson AR.
Allergy Asthma Clin Immunol 2012 Mar 2;8(1):2

Occupational asthma related to low levels of airborne methylene diphenyl diisocyanate (MDI) in orthopedic casting work.  
Suojalehto H, Linstrom I, Henriks-Eckerman ML, Jungewelter S, Suuronen K.
Am J Ind Med 2011 Dec;54(12):906-910
Click to view abstract

Is there any correlation between the results of skin-prick test and the severity of symptoms in allergic rhinitis?  
Tatar EC, Surenoglu UA, Saylam G, Isik E, Ozdek A, Korkmaz H.
Am J Rhinol Allergy 2012 Jan;26(1):37-39

Orally exhaled nitric oxide in patients with seasonal allergic rhinitis during natural pollen season.  
Ciebiada M, Cichocki P, Kasztalska K, Majewski S, Gorska-Ciebiada M, Gorski P.
Am J Rhinol Allergy 2012 Jan;26(1):32-36

IgE reactivity patterns in patients with allergic rhinoconjunctivitis to ragweed and mugwort pollens.  
Canis M, Becker S, Groger M, Kramer MF.
Am J Rhinol Allergy 2012 Jan;26(1):31-35

Aspirin-sensitive asthma and upper airway diseases.  
Chang JE, Chin W, Simon R.
Am J Rhinol Allergy 2012 Jan;26(1):27-30

Diagnosis and treatment of allergic rhinitis due to house-dust mites in Spain.  
Valero A, Justicia JL, Vidal C, Rodriguez V, Munoz R, Garcia MA.
Am J Rhinol Allergy 2012 Jan;26(1):23-26

Aspirin-exacerbated respiratory disease in China: A cohort investigation and literature review.  
Fan Y, Feng S, Xia W, Qu L, Li X, Chen S, Ding M, Lai Y, Shi J, Xu G, Li H.
Am J Rhinol Allergy 2012 Jan;26(1):20-22

Allergen of the month-salt cedar.  
Weber RW.
Ann Allergy Asthma Immunol 2012 Mar;108(3):A11

Association of microbial IgE sensitizations with asthma in young children with atopic dermatitis.  
Ong PY, Ferdman RM, Church JA.
Ann Allergy Asthma Immunol 2012 Mar;108(3):212-213

Ranitidine-induced anaphylaxis with detection of serum specific IgE to ranitidine and human serum albumin conjugates.  
Jin HJ, Kim JE, Ye YM, Chang YS, Park HS.
Ann Allergy Asthma Immunol 2012 Mar;108(3):210-212

Intraoperative anaphylaxis induced by the gelatin component of thrombin-soaked gelfoam in a pediatric patient.  
Khoriaty E, McClain CD, Permaul P, Smith ER, Rachid R.
Ann Allergy Asthma Immunol 2012 Mar;108(3):209-210

Anaphylactic shock due to SonoVue.  
Levano JA, Jimenez MA, Laiseca A, Vives R.
Ann Allergy Asthma Immunol 2012 Mar;108(3):208-209

Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin.  
Djuric V, Bogic M, Popadic AP, Spiric VT, Raskovic S.
Ann Allergy Asthma Immunol 2012 Mar;108(3):207-208

Characterization of occupational sensitization by multiallergen immunoblotting in workers exposed to laboratory animals.  
Caballero ML, Ordaz E, Bermejo M, Rodriguez-Perez R, Alday E, Maqueda J, Moneo I.
Ann Allergy Asthma Immunol 2012 Mar;108(3):178-181

Surveillance of contrast-media-induced hypersensitivity reactions using signals from an electronic medical recording system.  
Kim MH, Park CH, Kim DI, Kim KM, Kim HK, Lim KH, Song WJ, Lee SM, Kim SH, Kwon HS, Park HW, Yoon CJ, Cho SH, Min KU, Kim YY, Chang YS.
Ann Allergy Asthma Immunol 2012 Mar;108(3):167-171

Mouse sensitization as an independent risk factor for asthma morbidity.  
Moncrief T, Kahn R, Assa'ad A.
Ann Allergy Asthma Immunol 2012 Mar;108(3):135-140

A case of severe asthma and peach allergy that improved with omalizumab therapy: a case report. [Japanese]  
Suzuki S, Matsuura T, Kimura T, Tazaki T, Fukuda M, Homma T, Matsukura S, Kurokawa M, Adachi M.
Arerugi 2012 Feb;61(2):215-223

Japanese guideline for care of contact dermatitis: the guess and identification of the allergens. [Japanese]  
Takayama K.
Arerugi 2012 Feb;61(2):175-180

Pollen dispersion of Cryptomeria japonica and Cupressaceae in ito city during 10 years. [Japanese]  
Fujii M, Okazaki K, Makiyama K, Hisamatsu K.
Arerugi 2012 Jan;61(1):51-62

Diagnosis and consultation rates of allergic diseases in 11-year old schoolchildren, and usefulness of allergy screening test at school. [Japanese]  
Mukaida K, Kusunoki T, Morimoto T, Sakuma M, Yasumi T, Nishikomori R, Heike T.
Arerugi 2012 Jan;61(1):41-50


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