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 Allergy Advisor Digest - October 2016
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Snippets NOT posted in the October 2016 Advisor Digest Newsletter

Read Allergen-specific IgE to food molecular components and age: From early childhood to adulthood.
Read Cross-sectional study on allergic sensitization of Austrian adolescents using molecule-based IgE profiling.
Read IgE-associated allergic disorders: Recent advances in etiology, diagnosis and treatment.
Read Role of food and aeroallergen sensitization in eosinophilic esophagitis in adults.
Read Non coeliac gluten sensitivity - A new disease with gluten intolerance.
Read Specific antibodies for the detection of Alternaria allergens and the identification of cross-reactive antigens in other fungi.
Read Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins?
Read Hypersensitivity reactions to implanted metal devices: facts and fictions.
Read Allergenic characterization of 27-kDa Glycoprotein, a novel heat stable allergen, from the pupa of silkworm, Bombyx mori.
Read Search for allergens from the pollen proteome of sunflower (Helianthus annuus l.): a major sensitizer for respiratory allergy patients.
Read Identification of novel short ragweed pollen allergens
Read Is kiwifruit allergy a matter in kiwifruit-cultivating regions? A population-based study.
Read Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2-9 years.
Read Motivations for avoiding wheat consumption in Australia: results from a population survey.
Read Rare, severe hypersensitivity reaction to potassium iodide.
Read Heated egg yolk challenge predicts the natural course of hen's egg allergy: a retrospective study.

Snippets posted in the October 2016 Advisor Digest Newsletter

Read IgE cross-reactivity of peanut with walnut and soybean in children with food allergy.
Read Alpha-gal is a possible target of IgE-mediated reactivity to antivenom.
Read Threshold dose distribution and eliciting dose of cashew nut allergy.
Read Anaphylaxis conundrum: a trojan horse phenomenon.
Read Initial and accidental reactions are managed inadequately in children with sesame allergy.
Read Relevance of allergenic sensitization to Cynodon dactylon and Phragmites communis: Cross-reactivity with Pooideae grasses.
Read Hypersensitivity to quail egg proteins: what about hen egg?
Read Occupational asthma in a fruit and vegetables vendor
Read A Single-Chain Antibody for Detection of Major Fish Allergens, Parvalbumins
Read Hypersensitivity linked to exposure of broad bean protein(s)
Read Evaluation of the antigenic activity of camel whey protein hydrolysate

Allergy and Intolerance Abstracts
Allergen-specific IgE to food molecular components and age: From early childhood to adulthood.
This study aimed to evaluate the impact of age on serum allergen-specific IgE to molecular component levels in a large sample of subjects. Serum IgE to: rCor a11, rPru p3, nJug r3, rAra h8, rGly m4, rCor a8, nPen m1, nAct d8, Bos d 8, and nGal d2 were assessed by ISAC method. Sera from 2795 patients, median age 23 years were analysed. The number of positive tests (i.e. sensitisation) tended to increase between birth and school-age until young adulthood and then decreased. A similar age-dependent trend was observed considering the levels of each allergen components: the levels of each allergen component tended to increase until early adulthood, but Gal d 2 and Bos d 8 (rapidly diminishing), and then to decrease over time. However, the pattern is significantly dependent on each single tested food.

Allergen-specific IgE to food molecular components and age: From early childhood to adulthood.  
Tosca MA, Silvestri M, Olcese R, Sacco O, Pistorio A, Rossi GA, Ciprandi G.
Allergol Immunopathol (Madr ) 2016 Oct 5;

Click to view abstract

Index
Allergy and Intolerance Abstracts
Cross-sectional study on allergic sensitization of Austrian adolescents using molecule-based IgE profiling.
The aim of this cross-sectional study was to analyze the sensitization profiles of an Austrian adolescent population utilizing molecule-based IgE diagnosis. Serum samples of 501 non-selected pupils from Salzburg, Austria, were tested in ImmunoCAP ISAC(R) for IgE reactivity to 112 single allergens. In the population aged 12-21 years, 53.5% showed IgE reactivity to at least one allergen tested. The highest prevalence was found for Phl p 1 from grass pollen (26.5%), group 2 mite allergens (18.2%), Bet v 1 from birch pollen (16.3%) and Fel d 1 from cat (14.4%). The majority of participants showed a complex sensitization profile and reacted on average to 9 allergens. Pollen sensitization was highly prevalent (41.7%) and mainly driven by group I grass and PR-10 allergens of the birch family, while Pla l 1 represented the most relevant weed. Diagnosed and self-reported allergies were noted in 21.8% and 55.5% of participants, respectively and correlated well with in vitro results. Among atopic individuals, 71.4% reported to suffer from at least one allergy; concordance was found for grass and cat sensitization while venom and weed pollen positive individuals were frequently asymptomatic.

Cross-sectional study on allergic sensitization of Austrian adolescents using molecule-based IgE profiling.  
Stemeseder T, Klinglmayr E, Moser S, Lueftenegger L, Lang R, Himly M, Oostingh GJ, Zumbach J, Bathke AC, Hawranek T, Gadermaier G.
Allergy 2016 Oct 18;

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Index
Allergy and Intolerance Abstracts
IgE-associated allergic disorders: Recent advances in etiology, diagnosis and treatment.
IgE-associated allergic diseases belong to the most common inflammatory conditions. Their clinical manifestation ranges from mild symptoms to life-threatening episodes. Often patients experience a reduction in physical and psychologic well-being and suffer from a decreased quality-of-life due to disease activity. The continuously rising number of people that are affected by an allergic condition indicates an urgent need for better diagnostics and more efficient treatment options. Recent progress in the understanding of pathophysiologic mechanisms underlying IgE-associated allergic disorders have led to the identification of novel therapeutic targets and the development of drug candidates that are currently under evaluation. In this review, we highlight studies and clinical trials, which have helped to gain further insight in the etiology of IgE-associated allergic conditions as well as advances in the development of diagnostic tools and therapeutic approaches recently published in the European Journal of Allergy and Clinical Immunology.

IgE-associated allergic disorders: Recent advances in etiology, diagnosis and treatment.  
Zellweger F, Eggel A.
Allergy 2016 Oct 6;

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Index
Allergy and Intolerance Abstracts
Role of food and aeroallergen sensitization in eosinophilic esophagitis in adults.
Evaluation of IgE-mediated food sensitivity is frequently performed for patients with eosinophilic esophagitis (EoE). However, the clinical relevance of identifying IgE-mediated sensitivity to foods in adults is unclear. The objective of this study was to determine whether EoE associated with food or aeroallergen sensitivity represents a phenotype of EoE with distinct clinical or biological features. It concludes that adults with EoE and IgE-mediated food sensitivity are not phenotypically different than non-food sensitive patients. There is no clear clinical utility in identifying food sensitivity in adults with EoE. Further studies are needed to determine whether aeroallergen sensitivity represents a distinct phenotype of EoE

Role of food and aeroallergen sensitization in eosinophilic esophagitis in adults.  
Olson AA, Evans MD, Johansson MW, Kim CH, Manthei DM, Gaumnitz EA, Mathur SK.
Ann Allergy Asthma Immunol 2016 Oct;117(4):387-393

Click to view abstract

Index
Allergy and Intolerance Abstracts
Non coeliac gluten sensitivity - A new disease with gluten intolerance.
Until recently gluten intolerance has been believed to be typical of celiac disease (CD) and wheat allergy (WA). In the last few years, however, several study results have been published that have proved that gluten intolerance can also affect people who do not suffer from any of the above mentioned diseases. The new syndrome has been named non-celiac gluten sensitivity (NCGS) or gluten sensitivity (GS). It has been included in the new list of gluten-related disorders published in 2012. Researchers believe that NCGS is the most common syndrome of gluten intolerance. This review discusses many aspects of NCGS epidemiology, pathophysiology, clinical spectrum, and treatment and current tools to identify patients suffering from CD, WA, and NCGS

Non coeliac gluten sensitivity - A new disease with gluten intolerance.  
Czaja-Bulsa G.
Clin Nutr 2015 Apr;34(2):189-194

Click to view abstract

Index
Allergy and Intolerance Abstracts
Specific antibodies for the detection of Alternaria allergens and the identification of cross-reactive antigens in other fungi.
A. alternata extracts show great variations regarding allergenic potency. The aim of this study was to generate antibody probes specific for important Alternaria allergens and to use them to study allergen expression, depending on different culture conditions, as well as to search for cross-reactive allergens in other mould species. Synthetic peptides from antigenic regions of A. alternata allergens (Alt a 1, Alt a 2, Alt a 3, Alt a 6 and Alt a 8) were used to raise highly specific rabbit antibodies. These antibodies and IgE from allergic patients were used to detect allergens by immunoblotting in extracts of 4 A. alternata strains grown under varying culturing conditions, in commercial skin-prick extracts and in closely (Cladosporium herbarum and Aureobasidium pullulans) or distantly related (Aspergillus niger and Penicillium chrysogenum) mould species.

There was a wide variation of expression of the individual A. Alternata allergens, depending on the strain and culture conditions, but the antibody probes allowed us to distinguish strains and culture conditions with low and high allergen expression. In the commercial skin-prick solutions, varying levels of Alt a 1 were found, but no other allergens were detectable. Alt a 1 was identified as species-specific A. Alternata allergen, whereas Alt a 3, 6- and Alt a 8-cross-reactive antigens were found in C.herbarum and/or A. pullulans.

Specific antibodies for the detection of Alternaria allergens and the identification of cross-reactive antigens in other fungi.  
Twaroch TE, Curin M, Sterflinger K, Focke-Tejkl M, Swoboda I, Valenta R.
Int Arch Allergy Immunol 2016 Oct 26;170(4):269-278

Click to view abstract

Index
Allergy and Intolerance Abstracts
Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins?
In this study, the house dust mite Dermatophagoides pteronyssinus (DP) proteome was evaluated using RNA-seq methods as a proxy to assess the abundance of all proteins in this source. In addition, the thermodynamic stabilities of 656 nonallergens and 19 allergens were evaluated using a combined chemical denaturation and mass spectrometry approach. The results showed that when expression and stability are considered in combination, the allergens are a statistically different population from other DP proteins. The allergens are more stable and more highly expressed. The combination of high levels of transcription and stability for the major allergens Der p 1, Der p 2, and Der p 23 is rare (<2% of all DP proteins) but not unique.

Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins?  
Ogburn RN, Randall TA, Xu Y, Roberts JH, Mebrahtu B, Karnuta JM, Rider SD, Kissling GE, London RE, Pomes A, Arlian L, Fitzgerald MC, Mueller GA.
J Allergy Clin Immunol 2016 Oct 13;

Index
Allergy and Intolerance Abstracts
Hypersensitivity reactions to implanted metal devices: facts and fictions.
The use of metals in the medical field has become increasingly prevalent over the past few decades. Patients find themselves being exposed to metals in a variety of ways, ranging from external exposure to instruments such as the stainless steel in surgical blades to internal exposure via medical devices being implanted in their bodies. There has been growing interest in the possibility of developing hypersensitivity reactions to constituent metals in medical implant devices, both in cutaneous and systemic forms. Hypersensitivity reactions to metals are uncommon, but they are reported and require appropriate evaluation and management, particularly if they are symptomatic. In view of the lack of consensus in the field on the appropriate steps to evaluate and manage patients with suspected metal hypersensitivity reactions, this review aims to analyze current evidence on hypersensitivity reactions to metallic implants in orthopedic surgery, endovascular surgery, obstetrics and gynecology, and dental surgery.

Hypersensitivity reactions to implanted metal devices: facts and fictions.  
Teo Wendy ZW, Schalock PC.
J Investig Allergol Clin Immunol 2016 Oct;26(5):279-294

Click to view abstract

Index
Allergy and Intolerance Abstracts
Allergenic characterization of 27-kDa Glycoprotein, a novel heat stable allergen, from the pupa of silkworm, Bombyx mori.
Boiled silkworm pupa is a traditional food in Asia, and patients with silkworm pupa food allergy are common in these regions. Only one allergen from silkworm, arginine kinase, has been identified. The purpose of this study was to identify novel food allergens in silkworm pupa by analyzing a protein extract after heat treatment. Heat treated extracts were examined by proteomic analysis. A 27-kDa glycoprotein was identified, expressed in Escherichia coli, and purified. The molecular identities of these proteins, however, could not be determined. IgE reactivity toward a 27-kDa glycoprotein was also increased after heating the protein extract. The recombinant protein was recognized by IgE antibodies from allergic subjects (33.3%). Glycation or aggregation of protein by heating may create new IgE binding epitopes. Heat stable allergens are shown to be important in silkworm allergy.

Allergenic characterization of 27-kDa Glycoprotein, a novel heat stable allergen, from the pupa of silkworm, Bombyx mori.  
Jeong KY, Son M, Lee JY, Park KH, Lee JH, Park JW.
J Korean Med Sci 2016 Jan;31(1):18-24

Index
Allergy and Intolerance Abstracts
Search for allergens from the pollen proteome of sunflower (Helianthus annuus l.): a major sensitizer for respiratory allergy patients.
The present study aimed to identify the prevalence of sunflower pollinosis among the Indian allergic population and characterizes the pollen allergens using immuno-proteomic tools. Prevalence of sunflower pollen sensitization was observed among 21% of the pollen allergic population and associated with elevated level of specific IgE and histamine in the sera of these patients. Immunoscreening of sunflower pollen proteome with patient sera detected seven IgE-reactive proteins with varying molecular weight and pI. Hierarchical clustering of 2D-immunoblot data highlighted three allergens characterized by a more frequent immuno-reactivity and increased levels of IgE antibodies in the sera of susceptible patients. These allergens were considered as the major allergens of sunflower pollen. Homology search identified seven previously unreported allergens from sunflower pollen. Three major allergenic proteins were identified as two pectate lyases and a cysteine protease. (Ghosh 2015 ref.32288 5)

Search for allergens from the pollen proteome of sunflower (Helianthus annuus l.): a major sensitizer for respiratory allergy patients.  
Ghosh N, Sircar G, Saha B, Pandey N, Gupta Bhattacharya S.
Miscellaneous PLoS One 2015 Sep 29;10(9):e0138992.

Abstract

Index
Allergy and Intolerance Abstracts
Identification of novel short ragweed pollen allergens
Allergy to short ragweed (Ambrosia artemisiifolia) pollen is a serious and expanding health problem in North America and Europe. Whereas only 10 short ragweed pollen allergens are officially recorded, patterns of IgE reactivity observed in ragweed allergic patients suggest that other allergens contribute to allergenicity. The objective of the present study was to identify novel allergens following extensive characterization of the transcriptome and proteome of short ragweed pollen. 573 proteins were detected in the short ragweed pollen. Patterns of IgE reactivity of individual sera from 22 allergic patients were assessed. Analyses revealed the presence of multiple unreported IgE reactive proteins, including new Amb a 1 and Amb a 3 isoallergens as well as 7 novel candidate allergens reacting with IgEs from 20-70% of patients. The latter encompass members of the carbonic anhydrase, enolase, galactose oxidase, GDP dissociation inhibitor, pathogenesis related-17, polygalacturonase and UDP-glucose pyrophosphorylase families. These findings have implications for both diagnosis and allergen immunotherapy purposes.

Identification of novel short ragweed pollen allergens using combined transcriptomic and immunoproteomic approaches.  
Bordas-Le Floch V, Le Mignon M, Bouley J, Groeme R, Jain K, Baron-Bodo V, Nony E, Mascarell L, Moingeon P.
Miscellaneous PLoS One 2015 Aug 28;10(8):e0136258.

Abstract

Index
Allergy and Intolerance Abstracts
Is kiwifruit allergy a matter in kiwifruit-cultivating regions? A population-based study.
Although kiwifruit is known as a common cause of food allergy, population based studies concerning the prevalence of kiwifruit allergy does not exist. The authors aimed to determine the prevalence and clinical characteristics of IgE-mediated kiwifruit allergy in 6-18 year old urban schoolchildren in a region where kiwifruit is widely cultivated. The study recruited 20,800 of the randomly selected 6-18-year-old urban schoolchildren from the Rize city in the eastern Black Sea region of Turkey. The response rate to the questionnaire was 75.9%. The estimated prevalence of parental-perceived IgE-mediated kiwifruit allergy was 0.5%. Of the 72 children, 52 (72.2%) were skin tested, and 17 (32.7%) were found to be positive to kiwifruit with both commercial extract and kiwifruit. The most frequently reported symptoms in kiwi SPT-positive children were cutaneous (n = 10, 58.8%) followed by gastrointestinal (n = 6, 35.3%) and bronchial (n = 4, 23.5%). Oral symptoms were reported in six (35.3%) children. All children with kiwifruit positive SPTs were found positive during the oral challenge. The confirmed prevalence of IgE-mediated kiwifruit allergy by means of open OFC in 6-18-year-old urban schoolchildren living in Rize city was 0.10%.

Is kiwifruit allergy a matter in kiwifruit-cultivating regions? A population-based study.  
Haktanir AM, Dereci S, Hacisalihoglu S, Orhan F.
Pediatr Allergy Immunol 2016 Oct 12;

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Allergy and Intolerance Abstracts
Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2-9 years.
Recently, a few studies have linked soft drink consumption to increased asthma risk, but the contribution of different types of soft drinks is unknown. We investigated cross-sectional associations between six different types of soft drinks and asthma in 11-year-old children. We analyzed data of 2406 children participating in the Dutch Prevention and Incidence of Asthma and Mite Allergy birth cohort. At age 11, children self-reported consumption of sugar-added drinks, diet drinks, sweetened milk drinks, 100% fruit juice, energy drinks and sport drinks. The definition of asthma was based on parental reports of wheezing, prescription of inhaled corticosteroids and doctor's diagnosis of asthma. The prevalence of asthma in this study was 5.8%. In adjusted logistic regression analyses, asthma risk was increased for high (?10 glasses/week (gl/wk) versus low (<4 gl/wk) consumption of 100% fruit juice (odds ratio (OR): 2.09, 95% confidence interval (CI): 1.21-3.60), sugar-added drinks (OR: 1.56, 95%CI: 0.95-2.56) and for very high (>21.5 gl/wk) versus low (<12.5 gl/wk) total sugar-containing beverage (SCB) consumption (OR: 1.91, 95%CI: 1.04-3.48). Consumption of other beverages and consumption of fruit were not associated with increased asthma risk. No evidence for mediation of the observed associations by body mass index was found.

CONCLUSIONS:

This study indicates that high consumption of 100% fruit juice and total SCBs is associated with increased asthma risk in children. The positive association between consumption of 100% fruit juice and asthma is an unexpected finding that needs confirmation in future studies.

Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2-9 years.  
DeChristopher LR, Uribarri J, Tucker KL.
Public Health Nutr 2016 Jan;19(1):123-130

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Allergy and Intolerance Abstracts
Motivations for avoiding wheat consumption in Australia: results from a population survey.
The data indicate that many adult Australians are consciously avoiding consumption of wheat foods, predominantly without any formal diagnosis. Reported symptoms suggest a physiological but not allergenic basis to this behaviour. Questions to be answered concern whether symptoms are attributed correctly to wheat, the agents (wheat components, dietary factors or additives) and physiological mechanism(s) involved, the nutritional adequacy of avoiders' diets, and the clinical and psychosocial processes that lead a substantial number of adults to avoid consuming wheat (or any other dietary factor) apparently independently of a medical diagnosis

Motivations for avoiding wheat consumption in Australia: results from a population survey.  
Golley S, Corsini N, Topping D, Morell M, Mohr P.
Public Health Nutr 2015 Feb;18(3):490-499

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Index
Allergy and Intolerance Abstracts
Rare, severe hypersensitivity reaction to potassium iodide.
A severe hypersensitivity reaction to potassium iodide in a 51-year-old woman with Graves' thyrotoxicosis is described. Following administration the patient developed sialadenitis, conjunctivitis, stomatitis and acneiform iododerma that responded dramatically to withdrawal of the potassium iodide and administration with corticosteroids.

Rare, severe hypersensitivity reaction to potassium iodide. [Danish]  
Korsholm AS, Ebbehoj E, Richelsen B.
Ugeskr Laeger 2014 Jul 7;176(28):V01140002

Index
Allergy and Intolerance Abstracts
Heated egg yolk challenge predicts the natural course of hen's egg allergy: a retrospective study.
Children do not always outgrow hen's egg allergies in early childhood. Because egg yolks are less allergenic than egg whites, we performed an oral food challenge with heated egg yolk slightly contaminated with egg white (EYSEW OFC) in infants allergic to hen's egg. We hypothesized that the EYSEW OFC results would predict the egg allergy's natural course. Of the 197 included participants (median age: 18.3 months; range: 12.1-23.8 months), 179 (90.9 %) were EYSEW tolerant and 18 (9.1 %) were EYSEW reactive. At 36 months after the first EYSEW OFC, 164 EYSEW-tolerant (91.6 %) and 12 EYSEW-reactive participants (66.7 %) achieved heated hen's egg tolerance. In the univariate logistic regression analyses, EYSEW-reactive participants and those with baseline egg white sIgE levels had greater odds of persistent allergy to hen's egg at 36 months after the first EYSEW OFC. Classifying infants who are allergic to hen's egg into EYSEW tolerant and EYSEW reactive groups was useful in determining prognosis

Heated egg yolk challenge predicts the natural course of hen's egg allergy: a retrospective study.  
Okada Y, Yanagida N, Sato S, Ebisawa M.
World Allergy Organ J 2016;9(1):31

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Index

Allergen-, Food allergy-, Intolerance-related articles

IgE cross-reactivity of peanut with walnut and soybean in children with food allergy.  
Kim MN, Lee KE, Hong JY, Kim KW, Kim KE, Sohn MH, Park JW.
Allergol Immunopathol (Madr ) 2016 Oct 7;
Click to view abstract

Allergen-specific IgE to food molecular components and age: From early childhood to adulthood.  
Tosca MA, Silvestri M, Olcese R, Sacco O, Pistorio A, Rossi GA, Ciprandi G.
Allergol Immunopathol (Madr ) 2016 Oct 5;
Click to view abstract

Assessment of IgE-mediated food allergies in children with atopic dermatitis.  
Mavroudi A, Karagiannidou A, Xinias I, Cassimos D, Karantaglis N, Farmaki E, Imvrios G, Fotoulaki M, Eboriadou M, Tsanakas J.
Allergol Immunopathol (Madr ) 2016 Oct 4;
Click to view abstract

Food allergy: Current perspectives.  
Ebisawa M, Izuhara K.
Allergol Int 2016 Oct;65(4):361-362

European symposium on the awareness of allergy: report of the promotional campaign in the European Parliament (April 26-28, 2016).  
Muraro A, Steelant B, Pietikainen S, Borrelli D, Childers N, Callebaut I, Kortekaas K, Martens K, Pugin B, Dan-Popescu F, Vieru M, Jutel M, Agache I, Hellings PW.
Allergy 2016 Oct 3;
Click to view abstract

Alpha-gal is a possible target of IgE-mediated reactivity to antivenom.  
Fischer J, Eberlein B, Hilger C, Eyer F, Eyerich S, Ollert M, Biedermann T.
Allergy 2016 Oct 24;
Click to view abstract

Cross-sectional study on allergic sensitization of Austrian adolescents using molecule-based IgE profiling.  
Stemeseder T, Klinglmayr E, Moser S, Lueftenegger L, Lang R, Himly M, Oostingh GJ, Zumbach J, Bathke AC, Hawranek T, Gadermaier G.
Allergy 2016 Oct 18;
Click to view abstract

Patching it together: Epicutaneous vaccination with heat labile Escherichia coli toxin against birch pollen allergy.  
Killingbeck SS, Ge MQ, Haczku A.
Allergy 2016 Oct 7;
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IgE-associated allergic disorders: Recent advances in etiology, diagnosis and treatment.  
Zellweger F, Eggel A.
Allergy 2016 Oct 6;
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Adrenaline in anaphylaxis treatment and self-administration: experience from an inner city emergency department.  
Mostmans Y, Grosber M, Blykers M, Mols P, Naeije N, Gutermuth J.
Allergy 2016 Oct 6;
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Air pollution, epigenetics, and asthma.  
Ji H, Biagini Myers JM, Brandt EB, Brokamp C, Ryan PH, Khurana Hershey GK.
Allergy Asthma Clin Immunol 2016;1251
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Influence of an Allergen-Specific Th17 Response on Remodeling of the Airways.  
Peters M, Kohler-Bachmann S, Lenz-Habijan T, Bufe A.
Am J Respir Cell Mol Biol 2016 Mar;54(3):350-358

Approach to the evaluation of adverse antibiotic reactions in patients with cystic fibrosis.  
Petroni DH, Aitken ML, Ham E, Chung S, Menalia L, Altman MC, Ayars AG.
Ann Allergy Asthma Immunol 2016 Oct;117(4):378-381
Click to view abstract

Role of food and aeroallergen sensitization in eosinophilic esophagitis in adults.  
Olson AA, Evans MD, Johansson MW, Kim CH, Manthei DM, Gaumnitz EA, Mathur SK.
Ann Allergy Asthma Immunol 2016 Oct;117(4):387-393
Click to view abstract

Threshold dose distribution and eliciting dose of cashew nut allergy.  
van der Valk JP, Gerth van Wijk R, Baumert JL, Nordlee JA, Vlieg-Boerstra BJ, de Groot H, Dubois AE, de Jong NW.
Ann Allergy Asthma Immunol 2016 Oct 20;

Patterns of allergen sensitization and self-reported allergic disease in parents of food allergic children.  
Makhija MM, Robison RG, Caruso D, Cai M, Wang X, Pongracic JA.
Ann Allergy Asthma Immunol 2016 Oct;117(4):382-386
Click to view abstract

Evaluation of venom allergy.  
Philipp A, Ferdman RM, Tam JS.
Ann Allergy Asthma Immunol 2016 Oct;117(4):344-347

Aphthous stomatitis.  
Shah K, Guarderas J, Krishnaswamy G.
Ann Allergy Asthma Immunol 2016 Oct;117(4):341-343

Clinical practice guideline for diagnosis and management of urticaria.  
Kulthanan K, Tuchinda P, Chularojanamontri L, Chanyachailert P, Korkij W, Chunharas A, Wananukul S, Limpongsanurak W, Benjaponpitak S, Wisuthsarewong W, Aunhachoke K, Wessagowit V, Cha.
Asian Pac J Allergy Immunol 2016 Sep;34(3):190-200
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An extensively hydrolysed casein-based formula for infants with cows' milk protein allergy: tolerance/hypo-allergenicity and growth catch-up.  
Dupont C, Hol J, Nieuwenhuis EE.
Br J Nutr 2015 Apr 14;113(7):1102-1112
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Effect of a protein-free diet in the development of food allergy and oral tolerance in BALB/c mice.  
Paula-Silva J, Santiago AF, Oliveira RP, Rosa ML, Carvalho CR, Amaral JF, Faria AM.
Br J Nutr 2015 Mar 28;113(6):935-943
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Nutritional adequacy of goat milk infant formulas for term infants: a double-blind randomised controlled trial.  
Zhou SJ, Sullivan T, Gibson RA, Lonnerdal B, Prosser CG, Lowry DJ, Makrides M.
Br J Nutr 2014 May;111(9):1641-1651
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Non coeliac gluten sensitivity - A new disease with gluten intolerance.  
Czaja-Bulsa G.
Clin Nutr 2015 Apr;34(2):189-194
Click to view abstract

Noncoeliac gluten sensitivity: a diagnostic dilemma.  
Branchi F, Aziz I, Conte D, Sanders DS.
Curr Opin Clin Nutr Metab Care 2015 Sep;18(5):508-514
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Food intolerance and allergy: increased incidence or contemporary inadequate diets?  
Skypala I, Vlieg-Boerstra B.
Curr Opin Clin Nutr Metab Care 2014 Sep;17(5):442-447
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Food allergy in children: what is new?  
Turner PJ, Boyle RJ.
Curr Opin Clin Nutr Metab Care 2014 May;17(3):285-293
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Excess free fructose and childhood asthma.  
DeChristopher LR.
Eur J Clin Nutr 2015 Dec;69(12):1371

Cow's milk allergy and neonatal short bowel syndrome: comorbidity or true association?  
Diamanti A, Fiocchi AG, Capriati T, Panetta F, Pucci N, Bellucci F, Torre G.
Eur J Clin Nutr 2015 Jan;69(1):102-106
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Associations of sugar-containing beverages with asthma prevalence in 11-year-old children: the PIAMA birth cohort.  
Berentzen NE, van S, Gehring U, Koppelman GH, Schaap LA, Smit HA, Wijga AH.
Eur J Clin Nutr 2015 Mar;69(3):303-308
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Semen allergy. [German]  
Allam JP, Haidl G, Novak N.
Hautarzt 2015 Dec;66(12):919-923

Pathogenesis of Aspirin-Induced Reactions in Aspirin-Exacerbated Respiratory Disease.  
Cahill KN, Laidlaw TM.
Immunol Allergy Clin North Am 2016 Nov;36(4):681-691
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Aspirin-Exacerbated Respiratory Disease as an Endotype of Chronic Rhinosinusitis.  
Stevens WW, Schleimer RP.
Immunol Allergy Clin North Am 2016 Nov;36(4):669-680
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Diagnostic Evaluation in Aspirin-Exacerbated Respiratory Disease.  
Williams AN.
Immunol Allergy Clin North Am 2016 Nov;36(4):657-668
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Clinical Characteristics of Aspirin-Exacerbated Respiratory Disease.  
Stevenson DD, White AA.
Immunol Allergy Clin North Am 2016 Nov;36(4):643-655
Click to view abstract

Specific antibodies for the detection of Alternaria allergens and the identification of cross-reactive antigens in other fungi.  
Twaroch TE, Curin M, Sterflinger K, Focke-Tejkl M, Swoboda I, Valenta R.
Int Arch Allergy Immunol 2016 Oct 26;170(4):269-278
Click to view abstract

A review of the nutritional composition, organoleptic characteristics and biological effects of the high oleic peanut.  
Derbyshire EJ.
Int J Food Sci Nutr 2014 Nov;65(7):781-790
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Gluten and wheat intolerance today: are modern wheat strains involved?  
de LM, Salen P.
Int J Food Sci Nutr 2014 Aug;65(5):577-581
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Early exposure to allergens: a new window of opportunity for non-communicable disease prevention in complementary feeding?  
Agostoni C, Laicini E.
Int J Food Sci Nutr 2014 Feb;65(1):1-2
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Occupational sensitization to epoxy resins in Northeastern Italy (1996-2010).  
Prodi A, Rui F, Fortina AB, Corradin MT, Filon FL.
Int J Occup Environ Health 2015;21(1):82-87

Respiratory symptoms, lung functions, and exhaled nitric oxide (FENO) in two types of fish processing workers: Russian trawler fishermen and Norwegian salmon industry workers.  
Shiryaeva O, Aasmoe L, Straume B, Bang BE.
Int J Occup Environ Health 2015;21(1):53-60

Anaphylaxis conundrum: a trojan horse phenomenon.  
Esquivel A, Busse WW.
J Allergy Clin Immunol Pract 2016 Oct 17;
Click to view abstract

Allergy profile should be updated after uneventful administration of a penicillin or penicillin-related antibiotic to a patient with penicillin allergy.  
Oliver WD, Heil EL, Thom KA, Martinez JP, Hayes BD.
J Allergy Clin Immunol Pract 2016 Oct 17;

Initial and accidental reactions are managed inadequately in children with sesame allergy.  
Segal L, Ben-Shoshan M, Alizadehfar R, Primeau MN, Asai Y, Killorn KR, Chan E, Cheuk S, Shand G, St-Pierre Y, Harada L, Clarke A.
J Allergy Clin Immunol Pract 2016 Oct 17;

Pharmacogenomics and adverse drug reactions: Primetime and not ready for primetime tests.  
Khan DA.
J Allergy Clin Immunol 2016 Oct;138(4):943-955
Click to view abstract

Are dust mite allergens more abundant and/or more stable than other Dermatophagoides pteronyssinus proteins?  
Ogburn RN, Randall TA, Xu Y, Roberts JH, Mebrahtu B, Karnuta JM, Rider SD, Kissling GE, London RE, Pomes A, Arlian L, Fitzgerald MC, Mueller GA.
J Allergy Clin Immunol 2016 Oct 13;

House dust mite driven asthma and allergen specific T cells depend on B cells when the amount of inhaled allergen is limiting.  
Dullaers M, Schuijs MJ, Willart M, Fierens K, Van MJ, Hammad H, Lambrecht BN.
J Allergy Clin Immunol 2016 Oct 13;
Click to view abstract

Human milk oligosaccharides and development of cow's milk allergy in infants.  
Seppo AE, Autran CA, Bode L, Jarvinen KM.
J Allergy Clin Immunol 2016 Oct 1;
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Innate generation of thrombin and intracellular oxidants in airway epithelium by allergen Der p 1.  
Zhang J, Chen J, len-Philbey K, Perera BC, Tachie-Menson T, Mangat SC, Garrod DR, Robinson C.
J Allergy Clin Immunol 2016 Oct;138(4):1224-1227

Understanding the feasibility and implications of implementing early peanut introduction for prevention of peanut allergy.  
Koplin JJ, Peters RL, Dharmage SC, Gurrin L, Tang ML, Ponsonby AL, Matheson M, Togias A, Lack G, Allen KJ.
J Allergy Clin Immunol 2016 Oct;138(4):1131-1141
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Relevance of allergenic sensitization to Cynodon dactylon and Phragmites communis: Cross-reactivity with Pooideae grasses.  
Lopez-Matas MA, Moya R, Cardona V, Valero A, Gaig P, Malet A, Vinas M, Garcia-Moral A, Labrador M, Alcoceba E, Ibero M, Carnes J.
J Investig Allergol Clin Immunol 2016 Oct;26(5):295-303
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Hypersensitivity reactions to implanted metal devices: facts and fictions.  
Teo Wendy ZW, Schalock PC.
J Investig Allergol Clin Immunol 2016 Oct;26(5):279-294
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Hypersensitivity to quail egg proteins: what about hen egg?  
Micozzi S, Bartolome B, Sanchis-Merino ME, Alfaya T, Aldunate T, Diaz M, Pastor-Vargas C.
J Investig Allergol Clin Immunol 2016 Oct;26(5):316-318

Allergenic characterization of 27-kDa Glycoprotein, a novel heat stable allergen, from the pupa of silkworm, Bombyx mori.  
Jeong KY, Son M, Lee JY, Park KH, Lee JH, Park JW.
J Korean Med Sci 2016 Jan;31(1):18-24

ASCIA guidelines for prevention of anaphylaxis in schools, pre-schools and childcare: 2015 update.  
Vale S, Smith J, Said M, Mullins RJ, Loh R.
J Paediatr Child Health 2015 Oct;51(10):949-954

Non-celiac gluten sensitivity: literature review.  
Mansueto P, Seidita A, D'Alcamo A, Carroccio A.
J Am Coll Nutr 2014;33(1):39-54
Click to view abstract

Occupational asthma in a fruit and vegetables vendor. [Italian]  
Baldassarre A, Dragonieri S, Luisi V, Musti M, Vimercati L.
Med Lav 2016 Mar 24;107(2):87-91

A Cross-Reactive Human Single-Chain Antibody for Detection of Major Fish Allergens, Parvalbumins, and Identification of a Major IgE-Binding Epitope.  
Bublin M, Kostadinova M, Fuchs JE, Ackerbauer D, Moraes AH, Almeida FC, Lengger N, Hafner C, Ebner C, Radauer C, Liedl KR, Valente AP, Breiteneder H.
Miscellaneous PLoS One 2015 Nov 18;10(11):e0142625.
Abstract

Search for allergens from the pollen proteome of sunflower (Helianthus annuus l.): a major sensitizer for respiratory allergy patients.  
Ghosh N, Sircar G, Saha B, Pandey N, Gupta Bhattacharya S.
Miscellaneous PLoS One 2015 Sep 29;10(9):e0138992.
Abstract

Identification of novel short ragweed pollen allergens using combined transcriptomic and immunoproteomic approaches.  
Bordas-Le Floch V, Le Mignon M, Bouley J, Groeme R, Jain K, Baron-Bodo V, Nony E, Mascarell L, Moingeon P.
Miscellaneous PLoS One 2015 Aug 28;10(8):e0136258.
Abstract

Introducing allergenic foods in infants.  
Bobrow RS.
N Engl J Med 2016 Aug 25;375(8):e16

Hypersensitivity linked to exposure of broad bean protein(s) in allergic patients and BALB/c mice.  
Kumar D, Kumar S, Verma AK, Sharma A, Tripathi A, Chaudhari BP, Kant S, Das M, Jain SK, Dwivedi PD.
Nutrition 2014 Jul;30(7-8):903-914
Click to view abstract

Is refined carbohydrate consumption related to allergic diseases?  
Delibasi T, Cakir E.
Nutrition 2014 Apr;30(4):401-402
Click to view abstract

Incidence rates of occupational diseases in the Dutch construction sector, 2010-2014.  
van der Molen HF, de Vries SC, Stocks SJ, Warning J, Frings-Dresen MH.
Occup Environ Med 2016 May;73(5):350-352

Severe anaphylaxis requiring intensive care during oral food challenge - it is not always peanuts.  
Niggemann B, Yurek S, Beyer K.
Pediatr Allergy Immunol 2016 Oct 25;
Click to view abstract

Is kiwifruit allergy a matter in kiwifruit-cultivating regions? A population-based study.  
Haktanir AM, Dereci S, Hacisalihoglu S, Orhan F.
Pediatr Allergy Immunol 2016 Oct 12;
Click to view abstract

Intakes of apple juice, fruit drinks and soda are associated with prevalent asthma in US children aged 2-9 years.  
DeChristopher LR, Uribarri J, Tucker KL.
Public Health Nutr 2016 Jan;19(1):123-130
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Motivations for avoiding wheat consumption in Australia: results from a population survey.  
Golley S, Corsini N, Topping D, Morell M, Mohr P.
Public Health Nutr 2015 Feb;18(3):490-499
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Sensitisation profile to airborne allergens of patients followed for asthma in Cotonou, Benin. A cross-sectional study using prick-tests. [French]  
Agodokpessi G, Ade G, Dovoedo N, Ade S, Wachinou AP, Fayomi B, Gninafon M.
Rev Mal Respir 2015 Nov;32(9):930-935

Evaluation of the antigenic activity of camel whey protein hydrolysate [French]  
N. Lahouel, O. Kheroua, F. Mezemaz, D. Saidi
Rev Fr Allergol 2016;56(6):471-476
Click to view abstract Click to view abstract

Treating allergic bronchopulmonary aspergillosis: the way forward.  
Moss RB.
Eur Respir J 2016 Feb;47(2):385-387

Chronic pulmonary aspergillosis: rationale and clinical guidelines for diagnosis and management.  
Denning DW, Cadranel J, Beigelman-Aubry C, Ader F, Chakrabarti A, Blot S, Ullmann AJ, Dimopoulos G, Lange C.
Eur Respir J 2016 Jan;47(1):45-68

Increased respiratory symptoms in COPD patients living in the vicinity of livestock farms.  
Borlee F, Yzermans CJ, van Dijk CE, Heederik D, Smit LA.
Eur Respir J 2015 Dec;46(6):1605-1614

Clinical features of serum sickness after Australian snake antivenom.  
Ryan NM, Downes MA, Isbister GK.
Toxicon 2015 Dec 15;108181-183

Rare, severe hypersensitivity reaction to potassium iodide. [Danish]  
Korsholm AS, Ebbehoj E, Richelsen B.
Ugeskr Laeger 2014 Jul 7;176(28):V01140002

Phyto-photo dermatitis. [Danish]  
Kofoed K.
Ugeskr Laeger 2014 Jul 7;176(28):V65019

Pollen information consumption as an indicator of pollen allergy burden. [German]  
Kmenta M, Zetter R, Berger U, Bastl K.
Wien Klin Wochenschr 2016 Jan;128(1-2):59-67

Heated egg yolk challenge predicts the natural course of hen's egg allergy: a retrospective study.  
Okada Y, Yanagida N, Sato S, Ebisawa M.
World Allergy Organ J 2016;9(1):31
Click to view abstract


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