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 Allergy Advisor Digest - September 2012
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Read Environmental and demographic risk factors for egg allergy in a population-based study of infants.
Read Immunologic evaluation of drug allergy.
Read Allergen component testing for food allergy: ready for prime time?
Read Immune response to nanomaterials: implications for medicine and literature review.
Read Usefulness and limitations of sequential serum tryptase for the diagnosis of anaphylaxis
Read Anaphylactic versus mild reactions to hazelnut and apple in a birch-endemic area: different sensitization profiles?
Read Increased level of antibodies cross-reacting with Ves v 5 and CRISP-2 in MAR-positive patients.
Read Parent report of physician diagnosis in pediatric food allergy.
Read Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy

Abstracts shared in September 2012 Advisor Digest Newsletter

Read Two flushing-like reaction cases from calcium pidolate who tolerated calcium carbonate.
Read IgE detection to alpha/beta/gamma-gliadin and its clinical relevance in wheat-dependent exercise-induced anaphylaxis.
Read Clinical features and the diagnostic value of component allergen-specific IgE in hymenoptera venom allergy.
Read The cockroach and allergic diseases.
Read Food-cooking processes modulate allergenic properties of hen's egg white proteins.
Read The achilles heel in melatonin: asthma.
Read Almond allergens: molecular characterization, detection, and clinical relevance.
Read Anaphylactic reaction to probiotics. Cow's milk and hen's egg allergens in probiotic compounds.

Allergy and Intolerance Abstracts
Environmental and demographic risk factors for egg allergy in a population-based study of infants.
Although egg allergy is the most common food allergy in infants and young children, risk factors for egg allergy remain largely unknown. In a study of 5276 infants (HealthNuts), infants underwent skin prick testing (SPT) to egg white at 12 months of age. Questionnaire data on relevant exposures were obtained. 699/873 (80%) infants eligible for oral food challenge (detectable wheal on SPT) attended for formal assessment of egg allergy status; 453 had confirmed egg allergy (positive challenge and SPT >/= 2 mm). Children with older siblings and those with a pet dog at home were less likely to develop egg allergy by 1 year of age. Caesarean section delivery, antibiotic use in infancy, childcare attendance and maternal age were not associated with egg allergy. History of allergic disease in an immediate family member and having parents born in East Asia were strong risk factors for infantile egg allergy.

Environmental and demographic risk factors for egg allergy in a population-based study of infants.  
Koplin JJ, Dharmage SC, Ponsonby AL, Tang ML, Lowe AJ, Gurrin LC, Osborne NJ, Martin PE, Robinson MN, Wake M, Hill DJ, Allen KJ.
Allergy 2012 Sep 7;

Click to view abstract

Index
Allergy and Intolerance Abstracts
Immunologic evaluation of drug allergy.
Hypersensitivity drug reactions (HDR) consist of an individual abnormal response with the involvement of the immunological system. In addition to specific immunological mechanisms where specific antibodies or sensitised T cells participate, release of inflammatory mediators by non-specific immunological recognition may also occur. Within this category are one of the most common groups of drugs, the non-steroidal anti-inflammatory drugs. In addition to chemical drugs new emerging ones with an increasing protagonism are biological agents like humanised antibodies and others. For IgE dependent reactions both in vivo and in vitro tests can be used for the immunological evaluation. Sensitivity of these is not optimal and very often a drug provocation test must be considered for knowing the mechanism involved and/or establishing the diagnosis. For non-immediate reactions also both in vivo and in vitro tests can be used. Sensitivity for in vivo tests is generally low and in vitro tests may be needed for the immunological evaluation. Immunohistochemical studies of the affected tissue enable a more precise classification of non-immediate reactions. The monitorization of the acute response of the reactions has given clues for understanding these reactions and has promising results for the future of the immunological evaluation of HDR.

Immunologic evaluation of drug allergy.  
Gomez E, Torres MJ, Mayorga C, Blanca M.
Allergy Asthma Immunol Res 2012 Sep;4(5):251-263

Click to view abstract

Index
Allergy and Intolerance Abstracts
Allergen component testing for food allergy: ready for prime time?
Food allergies can cause life-threatening reactions and greatly influence quality of life. Accurate diagnosis of food allergies is important to avoid serious allergic reactions and prevent unnecessary dietary restrictions, but can be difficult. Skin prick testing (SPT) and serum food-specific IgE (sIgE) levels are extremely sensitive testing options, but positive test results to tolerated foods are not uncommon. Allergen component-resolved diagnostics (CRD) have the potential to provide a more accurate assessment in diagnosing food allergies. Recently, a number of studies have demonstrated that CRD may improve the specificity of allergy testing to a variety of foods including peanut, milk, and egg. While it may be a helpful adjunct to current diagnostic testing, CRD is not ready to replace existing methods of allergy testing, as it not as sensitive, is not widely available, and evaluations of component testing for a number of major food allergens are lacking

Allergen component testing for food allergy: ready for prime time?  
Kattan JD, Wang J.
Curr Allergy Asthma Rep 2012 Sep 26;

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Index
Allergy and Intolerance Abstracts
Immune response to nanomaterials: implications for medicine and literature review.
A review of the literature revealed an inflammatory response and an increased production of reactive oxidative species (ROS) to be common immune responses to nanomaterial use. The mechanisms by which the inflammatory response and ROS production occur will also be discussed

Immune response to nanomaterials: implications for medicine and literature review.  
Syed S, Zubair A, Frieri M.
Curr Allergy Asthma Rep 2012 Sep 2;

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Index
Allergy and Intolerance Abstracts
Usefulness and limitations of sequential serum tryptase for the diagnosis of anaphylaxis
"Tryptase is a biomarker related to the severity of anaphylaxis. However, since its concentration remains unaltered in a considerable number of patients during acute anaphylaxis, there is a need for more reliable diagnostic biological tests"

Usefulness and limitations of sequential serum tryptase for the diagnosis of anaphylaxis in 102 patients.  
Sala-Cunill A, Cardona V, Labrador-Horrillo M, Luengo O, Esteso O, Garriga T, Vicario M, Guilarte M.
Int Arch Allergy Immunol 2012 Sep 25;160(2):192-199

Click to view abstract

Index
Allergy and Intolerance Abstracts
Anaphylactic versus mild reactions to hazelnut and apple in a birch-endemic area: different sensitization profiles?
In the Mediterranean area, symptoms are more frequently severe and associated with sensitization to lipid transfer protein (LTP). This study compared patients with anaphylactic versus mild reactions to hazelnut and apple in The Netherlands, a birch-endemic area, with respect to sensitization to Bet v 1-homologues (i.e. PR10-proteins) and LTP. Methods: Twenty-one patients fulfilling the criteria for anaphylaxis and 21 with only mild symptoms (oral allergy) to hazelnut and/or apple were recruited. Specific immunoglobulin E to birch pollen, apple, hazelnut and PR10-proteins (rBet v 1, rPru p 1, rMal d 1 and rCor a 1) and recombinant LTP (rPru p 3 and rCor a 8) was measured by ImmunoCAP. Both mild and anaphylactic apple-allergic patients were sensitized to PR10-proteins, whereas only 1/7 of the mild and none of the anaphylactic apple-allergic patients was sensitized to LTP. In contrast, anaphylactic hazelnut-allergic patients displayed no such clear sensitization pattern: some were sensitized to both PR10-proteins and hazelnut LTP (1/9), and others to only LTP (2/9) or to only PR10-proteins (4/9) or to neither PR10-proteins nor LTP (2/9). Conclusion: This study shows that in a birch-endemic area, the sensitization profile to PR10-proteins and LTP in anaphylactic patients may differ between different plant foods. In this patient group, anaphylaxis to hazelnut can be LTP-associated, whereas anaphylaxis to apple is not.

Anaphylactic versus mild reactions to hazelnut and apple in a birch-endemic area: different sensitization profiles?  
Le TM, van HE, Lebens AF, Bruijnzeel-Koomen CA, Knulst AC.
Int Arch Allergy Immunol 2012 Aug 31;160(1):56-62

Click to view abstract

Index
Allergy and Intolerance Abstracts
Increased level of antibodies cross-reacting with Ves v 5 and CRISP-2 in MAR-positive patients.
Anti-sperm antibodies (ASA) have been described to be involved in immunological infertility. A possible antigen for ASA is the human cysteine-rich secretory protein 2 (CRISP-2), a sperm surface protein important in sperm-oocyte interaction. Furthermore, anti-CRISP-2 antibodies were shown to decrease fertility rates in vitro. Recently, cross-reacting antibodies recognizing CRISP-2 and antigen 5 from yellow jacket venom (Ves v 5) in human serum have been reported. This study investigatedd anti-Ves v 5 and CRISP-2 antibodies in sera from two groups of donors: MAR+ and MAR- patients. A higher incidence of allergy against hymenoptera venom was found in MAR+ patients. Interestingly, affinity-purified ASA from MAR+ patients' sera reacted against both Ves v 5 and CRISP-2, leading to sperm immobilization. Immunofluorescence analysis showed that ASA bound to the sperm surface, including the head part where CRISP-2 is localized. Taken together, these results showed a higher incidence of antibodies cross-reacting with Ves v 5 and CRISP-2 in MAR+ patients. This leads to the hypothesis that MAR+ patients may have a higher risk to develop wasp allergy.

Increased level of antibodies cross-reacting with Ves v 5 and CRISP-2 in MAR-positive patients.  
Brunner-Agten S, Pavlovic R, Muller L, Horn MP, Huber AR, Stadler BM, Vogel M.
Int Arch Allergy Immunol 2012 Aug 31;160(1):47-55

Click to view abstract

Index
Allergy and Intolerance Abstracts
Parent report of physician diagnosis in pediatric food allergy.
Thirty percent of parent-reported food allergies in this study were not diagnosed by a physician. One in 5 physician-diagnosed allergies was evaluated with oral food challenge. Understanding parent report of practices in food allergy provides insight into ways in which to streamline the diagnosis and management of care

Parent report of physician diagnosis in pediatric food allergy.  
Gupta RS, Springston EE, Smith B, Pongracic J, Holl JL, Warrier MR.
J Allergy Clin Immunol 2012 Sep 1;

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Index
Allergy and Intolerance Abstracts
Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy
This study concludes that six months of SOTI with raw hen's egg emulsion resulted in partial tolerance, with regular intake, in a significant percentage of children with severe egg allergy.

Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy: A randomized controlled trial.  
Dello I, Tripodi S, Calvani M, Panetta V, Verga MC, Miceli SS.
Pediatr Allergy Immunol 2012 Sep 9;

Click to view abstract

Index

Allergen-, Food allergy-, Intolerance-related articles

Long-term selective IgE-mediated hypersensitivity to hydrocortisone sodium succinate.  
Calogiuri GF, Nettis E, Di LE, Muratore L, Ferrannini A, Vacca A.
Allergol Immunopathol (Madr ) 2012 Sep 19;

Respiratory allergy to fungi in Barcelona, Spain: Clinical aspects, diagnosis and specific treatment in a general allergy unit.  
Torres-Rodriguez JM, Pulido-Marrero Z, Vera-Garcia Y.
Allergol Immunopathol (Madr ) 2012 Sep;40(5):295-300
Click to view abstract

Two flushing-like reaction cases from calcium pidolate who tolerated calcium carbonate.  
Nunez R, Carballada F, Boquete M.
Allergol Immunopathol (Madr ) 2012 Sep;40(5):318

Sensitization to acid-hydrolyzed wheat protein by transdermal administration to BALB/c mice, and comparison with gluten.  
Adachi R, Nakamura R, Sakai S, Fukutomi Y, Teshima R.
Allergy 2012 Sep 21;
Click to view abstract

House dust mite allergic airway inflammation facilitates neosensitization to inhaled allergen in mice.  
van Rijt LS, Logiantara A, Utsch L, Canbaz D, Boon L, van RR.
Allergy 2012 Sep 21;
Click to view abstract

IgE detection to alpha/beta/gamma-gliadin and its clinical relevance in wheat-dependent exercise-induced anaphylaxis.  
Hofmann SC, Fischer J, Eriksson C, Bengtsson GO, Biedermann T, Jakob T.
Allergy 2012 Sep 15;
Click to view abstract

Honey bee (Apis mellifera) venom induces AIM2 inflammasome activation in human keratinocytes.  
Dombrowski Y, Peric M, Koglin S, Kaymakanov N, Schmezer V, Reinholz M, Ruzicka T, Schauber J.
Allergy 2012 Sep 13;
Click to view abstract

A hypoallergenic variant of the major birch pollen allergen shows distinct characteristics in antigen processing and T-cell activation.  
Kitzmuller C, Wallner M, Deifl S, Mutschlechner S, Walterskirchen C, Zlabinger GJ, Ferreira F, Bohle B.
Allergy 2012 Sep 13;
Click to view abstract

Environmental and demographic risk factors for egg allergy in a population-based study of infants.  
Koplin JJ, Dharmage SC, Ponsonby AL, Tang ML, Lowe AJ, Gurrin LC, Osborne NJ, Martin PE, Robinson MN, Wake M, Hill DJ, Allen KJ.
Allergy 2012 Sep 7;
Click to view abstract

Human leukocyte antigens (HLA) associated drug hypersensitivity: consequences of drug binding to HLA.  
Yun J, Adam J, Yerly D, Pichler WJ.
Allergy 2012 Sep 3;
Click to view abstract

A case of allopurinol-induced fixed drug eruption confirmed with a lymphocyte transformation test.  
Kim MH, Shim EJ, Jung JW, Sohn SW, Kang HR.
Allergy Asthma Immunol Res 2012 Sep;4(5):309-310
Click to view abstract

Clinical features of allergic bronchopulmonary aspergillosis in Korea.  
Kim JH, Jin HJ, Nam YH, Hwang EK, Ye YM, Park HS.
Allergy Asthma Immunol Res 2012 Sep;4(5):305-308
Click to view abstract

Clinical features and the diagnostic value of component allergen-specific IgE in hymenoptera venom allergy.  
Shin YS, Liu JN, Hur GY, Hwang EK, Nam YH, Jin HJ, Lee SM, Ye YM, Nahm DH, Park HS.
Allergy Asthma Immunol Res 2012 Sep;4(5):284-289
Click to view abstract

The cockroach and allergic diseases.  
Sohn MH, Kim KE.
Allergy Asthma Immunol Res 2012 Sep;4(5):264-269
Click to view abstract

Immunologic evaluation of drug allergy.  
Gomez E, Torres MJ, Mayorga C, Blanca M.
Allergy Asthma Immunol Res 2012 Sep;4(5):251-263
Click to view abstract

Allergen of the month-english walnut.  
Weber RW.
Ann Allergy Asthma Immunol 2012 Sep;109(3):A13

Lipid transfer proteins and thaumatins as relevant allergens in melon peel allergy.  
Gandolfo-Cano M, Gonzalez-Mancebo E, Gonzalez-de-Olano D, Mohedano-Vicente E, Munoz-Garcia E, Bartolome B, Pastor-Vargas C.
Ann Allergy Asthma Immunol 2012 Sep;109(3):224-225

Sensitization to bald cypress and cross-reactivity with red cedar in Northeastern Georgia.  
Cannington EM, Roe KL, Young PF, Ownby DR.
Ann Allergy Asthma Immunol 2012 Sep;109(3):220-221

Pollen starch granules in bronchial inflammation.  
Badorrek P, Dick M, Emmert L, Schaumann F, Koch W, Hecker H, Murdoch R, Hohlfeld JM, Krug N.
Ann Allergy Asthma Immunol 2012 Sep;109(3):208-214
Click to view abstract

Three faces of allergen. [Japanese]  
Takai T.
Arerugi 2012 Jul;61(7):930-940

Allergen component testing for food allergy: ready for prime time?  
Kattan JD, Wang J.
Curr Allergy Asthma Rep 2012 Sep 26;
Click to view abstract

Immune response to nanomaterials: implications for medicine and literature review.  
Syed S, Zubair A, Frieri M.
Curr Allergy Asthma Rep 2012 Sep 2;
Click to view abstract

Usefulness and limitations of sequential serum tryptase for the diagnosis of anaphylaxis in 102 patients.  
Sala-Cunill A, Cardona V, Labrador-Horrillo M, Luengo O, Esteso O, Garriga T, Vicario M, Guilarte M.
Int Arch Allergy Immunol 2012 Sep 25;160(2):192-199
Click to view abstract

Differences in systemic and skin migrating-specific CD4 T cells in papular urticaria by flea bite.  
Dominguez-Amorocho O, Duarte S, Gonzalez JM, Halpert E, Ortega MC, Rodriguez A, Garcia E, Cuellar A.
Int Arch Allergy Immunol 2012 Sep 25;160(2):165-172
Click to view abstract

An investigation of airborne allergenic pollen at different heights.  
Xiao X, Fu A, Xie X, Kang M, Hu D, Yang P, Liu Z.
Int Arch Allergy Immunol 2012 Sep 25;160(2):143-151
Click to view abstract

Food-cooking processes modulate allergenic properties of hen's egg white proteins.  
Liu X, Feng BS, Kong X, Xu H, Li X, Yang PC, Liu Z.
Int Arch Allergy Immunol 2012 Sep 25;160(2):134-142
Click to view abstract

Clinical Management of Patients with a History of Urticaria/Angioedema Induced by Multiple NSAIDs: An Expert Panel Review.  
Asero R, Bavbek S, Blanca M, Blanca-Lopez N, Cortellini G, Nizankowska-Mogilnicka E, Quaratino D, Romano A, Sanchez-Borges M, Torres-Jaen MJ.
Int Arch Allergy Immunol 2012 Sep 25;160(2):126-133
Click to view abstract

Anaphylactic versus mild reactions to hazelnut and apple in a birch-endemic area: different sensitization profiles?  
Le TM, van HE, Lebens AF, Bruijnzeel-Koomen CA, Knulst AC.
Int Arch Allergy Immunol 2012 Aug 31;160(1):56-62
Click to view abstract

Increased level of antibodies cross-reacting with Ves v 5 and CRISP-2 in MAR-positive patients.  
Brunner-Agten S, Pavlovic R, Muller L, Horn MP, Huber AR, Stadler BM, Vogel M.
Int Arch Allergy Immunol 2012 Aug 31;160(1):47-55
Click to view abstract

The value of identifying major T Cell epitopes of clinically important allergens.  
Pickl WF.
Int Arch Allergy Immunol 2012 Aug 30;160(1):4-6
Click to view abstract

Towards a more complete standardization of mite allergen extracts.  
Fernandez-Caldas E.
Int Arch Allergy Immunol 2012 Aug 30;160(1):1-3
Click to view abstract

Assessment of sensitization to insect aeroallergens among patients with allergic rhinitis in Yazd City, Iran.  
Bemanian MH, Alizadeh KN, Shirkhoda S, Nabavi M, Pourpak Z.
Iran J Allergy Asthma Immunol 2012 Sep;11(3):253-258
Click to view abstract

The achilles heel in melatonin: asthma.  
Karasu-Minareci E, Kaya Y, Belgin YF.
Iran J Allergy Asthma Immunol 2012 Sep;11(3):246-252
Click to view abstract

Almond allergens: molecular characterization, detection, and clinical relevance.  
Costa J, Mafra I, Carrapatoso I, Oliveira MB.
J Agric Food Chem 2012 Feb 15;60(6):1337-49.

IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization.  
Chu DK, Llop-Guevara A, Walker TD, Flader K, Goncharova S, Boudreau JE, Moore CL, In TS, Waserman S, Coyle AJ, Kolbeck R, Humbles AA, Jordana M.
J Allergy Clin Immunol 2012 Sep 21;
Click to view abstract

Spiking venom with rVes v 5 improves sensitivity of IgE detection in patients with allergy to Vespula venom.  
Vos B, Kohler J, Muller S, Stretz E, Rueff F, Jakob T.
J Allergy Clin Immunol 2012 Sep 21;

Limitations of reliance on specific IgE for epidemiologic surveillance of food allergy.  
Keet CA, Wood RA, Matsui EC.
J Allergy Clin Immunol 2012 Sep 7;

Parent report of physician diagnosis in pediatric food allergy.  
Gupta RS, Springston EE, Smith B, Pongracic J, Holl JL, Warrier MR.
J Allergy Clin Immunol 2012 Sep 1;
Click to view abstract

Household mold as a predictor of asthma risk: Recent progress, limitations, and future directions.  
Rabinovitch N.
J Allergy Clin Immunol 2012 Sep;130(3):645-646

Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy: A randomized controlled trial.  
Dello I, Tripodi S, Calvani M, Panetta V, Verga MC, Miceli SS.
Pediatr Allergy Immunol 2012 Sep 9;
Click to view abstract

Anaphylactic reaction to probiotics. Cow's milk and hen's egg allergens in probiotic compounds.  
Martin-Munoz MF, Fortuni M, Caminoa M, Belver T, Quirce S, Caballero T.
Pediatr Allergy Immunol 2012 Sep 9;
Click to view abstract

World Allergy Organization study on aerobiology for creating first pollen and mold calendar with clinical significance in Islamabad, Pakistan;: a project of World Allergy Organization and Pakistan Allergy, Asthma & Clinical Immunology Centre of Islamabad  
Abbas, Shahid; Katelaris, Connie H.; Singh, Anand B.; Raza, Syed M.; Ajab Khan, Mir; Rashid, Muhammad; Abbas, Maryam; Ismail, Muhammad
WAO Journal 2012;5(9):103-110.
Click to view abstract Click to view abstract


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