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 Allergy Advisor Digest - September 2017
Editor: Dr. Harris A. Steinman

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This is a monthly digest of interesting information that is being added to Allergy Advisor. While we add a great deal of information every month, here we highlight some of the more interesting articles.
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Snippets NOT posted in the September 2017 Advisor Digest Newsletter

Read Hand eczema as a risk factor for food allergy among occupational kitchen workers.
Read Serine protease allergen favours Th2 responses via PAR-2 and STAT-3 activation in murine model.
Read Characterization of maize chitinase-A, a tough allergenic molecule.
Read Association of aeroallergen sensitization and atopic disease in the Sonoran Desert.
Read Age-Based Causes and Clinical Characteristics of Immediate-Type Food Allergy in Korean Children.
Read Oral food challenge outcomes in a pediatric tertiary care center.
Read Preventing severe asthma exacerbations in children. a randomized trial of mite-impermeable bedcovers.
Read Multicenter prevalence of anaphylaxis in clinic-based oral food challenges.
Read Single recombinant and purified major allergens and peptides: How they are made and how they change allergy diagnosis and treatment.
Read Pollen food allergy syndrome in Turkey: Clinical characteristics and evaluation of its association with skin test reactivity to pollens.
Read An interpretation of the new international MAP guideline for the management of Milk Allergy in Primary Care.
Read Cannabis-associated asthma and allergies.
Read Detection of the peanut allergens Ara h 2 and Ara h 6 in human breast milk: Development of 2 sensitive and specific sandwich ELISA assays.
Read Diagnostic value of oral challenge testing in the diagnosis of macrolide hypersensitivity.
Read A new allergen family involved in pollen food associated syndrome: snakin/gibberellin regulated proteins.
Read Aspergillus fumigatus alkaline protease 1 (Alp1/Asp f13) in the airways correlates with asthma severity.
Read Life after LEAP: How to implement advice on introducing peanuts in early infancy.
Read Association of household cleaning agents and disinfectants with asthma in young German adults.
Read Predicting occupational asthma and rhinitis in bakery workers referred for clinical evaluation.
Read Occupational allergy to fruit flies (Drosophila melanogaster) in laboratory workers.
Read Development of a prediction model for severe wheat allergy.
Read Oral challenge without skin tests in children with non-severe betalactam hypersensitivity: time to change the paradigm?
Read The impact of food allergens on airway responsiveness in schoolchildren with asthma
Read Critical Issues in Food Allergy: A National Academies Consensus Report.
Read Case report of subcutaneous nodules and sterile abscesses due to delayed type hypersensitivity to aluminum-containing vaccines.
Read Thumb-sucking, nail-biting, and atopic sensitization, asthma, and hay fever.
Read Cow's milk allergy and bone mineral density in prepubertal children.
Read Myths and misconceptions concerning contrast media-induced anaphylaxis: a narrative review.
Read Angio-oedema associated with colistin.

Snippets posted in the September 2017 Advisor Digest Newsletter

Read Hen's egg allergen in house and bed dust is significantly increased after hen's egg consumption-A pilot study.
Read Sensitization profiles to peanut allergens across the United States.
Read Specific IgE to peanut 2S albumin Ara h 7 has a discriminative ability comparable to Ara h 2 and 6.
Read Sunflower seed allergy.
Read Severe anaphylaxis due to crocodile-meat allergy exhibiting wide cross-reactivity with fish allergens.
Read Allergen sensitization in a birth cohort at midchildhood: Focus on food component IgE and IgG4 responses.
Read Celiac Disease and Nonceliac Gluten Sensitivity: A Review.
Read Gibberellin-regulated protein in Japanese apricot is an allergen cross-reactive to Pru p 7.
Read IgE reactivity to shrimp allergens in infants and their cross-reactivity to house dust mite.
Read A case of a 7-year-old girl with late-onset anaphylaxis to fermented soybeans.
Read Anaphylactic reactions to novel foods: Case report of a child with severe crocodile meat allergy.
Read Allergic rhinoconjunctivitis caused by occupational exposure to ginger.

Allergy and Intolerance Abstracts
Hand eczema as a risk factor for food allergy among occupational kitchen workers.
To explore the significance of hand eczema as a risk factor for food allergies in adults at the epidemiological level, the authors performed a cross-sectional web-based questionnaire survey on kitchen workers whose exposures were classed as occupational (cooks and food handlers, n = 1592) or non-occupational (housewives, n = 1915). Current hand eczema and current diagnosed food allergy were more common among occupational kitchen workers (OKW) than among non-occupational kitchen workers (NOKW) (32.3%-vs-29.9% and 9.9%-vs-3.8%, respectively). Current hand eczema was significantly associated with increased risk of current diagnosed food allergy in OKW (adjusted odds ratio 2.4, 95% CI 1.6-3.7). Those with more severe hand eczema were more likely to suffer from allergic symptoms for foods, and diagnosed food allergy.

Hand eczema as a risk factor for food allergy among occupational kitchen workers.  
Minami T, Fukutomi Y, Sekiya K, Akasawa A, Taniguchi M.
Allergol Int 2017 Sep 2;

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Allergy and Intolerance Abstracts
Serine protease allergen favours Th2 responses via PAR-2 and STAT-3 activation in murine model.
Protease activity of Per a 10 (American cockroach) favours Th2 responses by differential regulation of IL-12p70 and IL-23 cytokine subunits. The present study aims to elucidate the underlying mechanism of differential regulation of IL-12p70 and IL-23.

Serine protease allergen favours Th2 responses via PAR-2 and STAT-3 activation in murine model.  
Agrawal K, Arora N.
Allergy 2017 Sep 20;

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Allergy and Intolerance Abstracts
Characterization of maize chitinase-A, a tough allergenic molecule.
Plant chitinases are an example of food allergenic proteins for which structural analysis of allergenicity has only partially been reported. The recombinant maize chitinase, rChiA, was purified. Allergenicity of rChiA was verified by immunoblot assays with sera from allergic subjects. rChiA is active in the hydrolysis of glycol chitin and tetra-N-acetylchitotetraose and maintains its activity at high temperatures (70 degrees C) and low pH (pH 3). The molecule is also reactive with IgE from sera of maize-allergic subjects. The clinical importance of this allergen is still unclear as all the patients showing IgE reactivity towards rChiA also showed IgE reactivity to maize LTP, called Zea m 14, the most relevant maize allergen. However, the maize chitinase shares 62% similarity with a grape chitinase that is responsible for allergic reactions to grape and possibly to wine. Interestingly, patient N° 2, whose sera reacted strongly with rChiA, was clinically allergic to both maize and grape. Moreover it is noteworthy that three patients (1, 3 and 5) were clinically allergic to tomato, which has a chitinase that is 58% similar to maize ChiA. Thus this allergen could be used to identify patients with allergies to chitinases in multiple plant-foods.

Characterization of maize chitinase-A, a tough allergenic molecule.  
Volpicella M, Leoni C, Fanizza I, Distaso M, Leoni G, Farioli L, Naumann T, Pastorello E, Ceci LR.
Allergy 2017 Sep;72(9):1423-1429

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Allergy and Intolerance Abstracts
Association of aeroallergen sensitization and atopic disease in the Sonoran Desert.
Tucson, Arizona, is located in the Sonoran Desert, which has the highest diversity of vegetation of any desert in the world. Given the unique pollen profile in this region, we sought to identify the most common aeroallergens associated with rhinitis and asthma diagnosis in the local adult population. A retrospective electronic chart review of 226 consecutive adult patients who underwent aeroallergen skin-prick testing for rhinitis was conducted. Skin testing results were most commonly positive to mesquite (54%), Bermuda (48%), palo verde (47%), olive tree (43%), and chenopodium (43%). Compared with the subjects without asthma, those subjects with asthma were more often sensitized to molds, including Alternaria alternata, and cat hair and/or pelt.

Association of aeroallergen sensitization and atopic disease in the Sonoran Desert.  
Buckley RD, Carr TF.
Allergy Asthma Proc 2017 Sep 1;38(5):370-375

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Allergy and Intolerance Abstracts
Age-Based Causes and Clinical Characteristics of Immediate-Type Food Allergy in Korean Children.
This study investigated age-dependent clinical profiles of food allergy (FA) in Korean children through an extensive investigation in 14 tertiary hospitals in Korea. A total of 1,353 children and adolescents, 93% younger than 7 years, were enrolled in the present study, and 1,661 cases of immediate-type FA were recorded in these patients. The 7 major causative foods were cow's milk (28.1%), hen's eggs (27.6%), wheat (7.9%), walnuts (7.3%), peanuts (5.3%), buckwheat (1.9%), and shrimps (1.9%). Categorizing the patients into 4 age groups revealed that the most common causative food was different for each age group: cow's milk (<2 years), walnuts (2-6 years), walnuts (7-12 years), and buckwheat (13-18 years). The onset time of symptoms was less than 10 minutes in 49%, between 10 and 30 minutes in 17%, and between 30 minutes and 2 hours in 34% of cases. Food-induced anaphylaxis was reported in 506 (30.5%) out of 1,661 cases, and the 7 major causes of food-induced anaphylaxis was cow's milk (27.5%), hen's eggs (21.9%), wheat (11.3%), walnuts (10.5%), peanuts (5.9%), buckwheat (4.2%), and pine nuts (3.0%). The proportion of anaphylaxis was highest in the patients allergic to buckwheat (67.7%), followed by those allergic to pine nuts (57.7%), walnuts (43.8%), wheat (43.5%), and peanuts (34.1%).

Age-Based Causes and Clinical Characteristics of Immediate-Type Food Allergy in Korean Children.  
Jeong K, Kim J, Ahn K, Lee SY, Min TK, Pyun BY, Kim YH, Kim KW, Sohn MH, Kim KE, Jang GC, Song TW, Kim JH, Jeon YH, Lee YJ, Park YM, Yum HY, Kim HH, Kim WK, Lee S.
Allergy Asthma Immunol Res 2017 Sep;9(5):423-430

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Allergy and Intolerance Abstracts
Oral food challenge outcomes in a pediatric tertiary care center.
A retrospective chart review was done on all pediatric patients who had oral food challenges in a tertiary care pediatric allergy clinic from 2008 to 2010. 313 oral challenges were performed, of which the majority were to peanut (105), egg (71), milk (41) and tree nuts (29). There were 104 (33%) oral challenge failures. The risk of challenge failure differed with type of food studied, with peanut and tree nut having a higher risk of challenge failure and anaphylaxis. Cashew in particular carried a high risk and caution must be exercised when performing these types of oral challenges in children

Oral food challenge outcomes in a pediatric tertiary care center.  
Abrams EM, Becker AB.
Allergy Asthma Clin Immunol 2017;1343

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Allergy and Intolerance Abstracts
Preventing severe asthma exacerbations in children. a randomized trial of mite-impermeable bedcovers.
Mite-impermeable encasings are effective in reducing the number of mite-sensitized children with asthma attending the hospital with asthma exacerbations but not the number requiring oral prednisolone. This simple measure may reduce the health care burden of asthma exacerbations in children.

Preventing severe asthma exacerbations in children. a randomized trial of mite-impermeable bedcovers.  
Murray CS, Foden P, Sumner H, Shepley E, Custovic A, Simpson A.
Am J Respir Crit Care Med 2017 Jul 15;196(2):150-158

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Allergy and Intolerance Abstracts
Multicenter prevalence of anaphylaxis in clinic-based oral food challenges.
As the largest national survey of allergic reactions of clinical open OFCs in a nonresearch setting in the United States, this study found that performing clinical nonresearch open low-risk OFCs results in few allergic reactions, with 86% of challenges resulting in no reactions and 98% without anaphylaxis

Multicenter prevalence of anaphylaxis in clinic-based oral food challenges.  
Akuete K, Guffey D, Israelsen RB, Broyles JM, Higgins LJ, Green TD, Naimi DR, MacGinnitie AJ, Vitalpur G, Minard CG, Davis CM.
Ann Allergy Asthma Immunol 2017 Sep 1;

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Allergy and Intolerance Abstracts
Single recombinant and purified major allergens and peptides: How they are made and how they change allergy diagnosis and treatment.
This article reviews the current knowledge regarding recombinant and purified allergens and allergen-derived peptides. Advantages and drawbacks of pure and defined recombinant allergens and peptides over allergen extracts in the context of allergy research, diagnosis, and allergen immunotherapy are discussed. The authors describe how these molecules are manufactured, which products are currently available on the market, and what the regulative issues are. They furthermore provide an overview of clinical studies with vaccines based on recombinant allergens and synthetic peptides. The possibility of prophylactic vaccination based on recombinant fusion proteins consisting of viral carrier proteins and allergen-derived peptides without allergenic activity are also discussed.

Single recombinant and purified major allergens and peptides: How they are made and how they change allergy diagnosis and treatment.  
Curin M, Garib V, Valenta R.
Ann Allergy Asthma Immunol 2017 Sep;119(3):201-209

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Allergy and Intolerance Abstracts
Pollen food allergy syndrome in Turkey: Clinical characteristics and evaluation of its association with skin test reactivity to pollens.
There is limited data regarding pollen food allergy syndrome (PFAS) in Turkey. A total of 254 consecutive adult patients with pollen sensitivity were prospectively recruited. Self-reported PFAS was observed in 49 patients (19.3%). The most common culprit foods were kiwi, peach, tomato, melon and watermelon. Therefore PFAS is frequent in pollen sensitized adults in Turkey.

Pollen food allergy syndrome in Turkey: Clinical characteristics and evaluation of its association with skin test reactivity to pollens.  
Ozdemir SK, Ozguvarsigmalu S.
Asian Pac J Allergy Immunol 2017 Sep 17;

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Allergy and Intolerance Abstracts
An interpretation of the new international MAP guideline for the management of Milk Allergy in Primary Care.
General Practitioners suffer from guideline fatigue. They come fast and furious in many complicated forms. Cow's milk allergy (CMA) is one of the most common presentations of food allergy seen in early childhood presenting to primary and secondary care. The early and accurate diagnosis continues to be highlighted in many countries worldwide. International surveys have found that primary care clinicians would like clearer explanations for the options for the diagnosis of CMA and in so doing a means to increase their understanding of management options for both IgE and Non IgE mediated CMA. In 2013 in response to General Practitioner demands, the UK guideline, 'Diagnosis and management of non-IgE-mediated CMA in infancy-a UK primary care practical guide' was published in this journal. This Milk Allergy in Primary Care (MAP) guideline outlines in simple algorithmic form how to diagnose, manage and refer children with CMA in a primary care setting. Based on the international uptake of the MAP guideline, a global practical guideline International MAP is presented by the Venter and Brown et al to help practitioners in primary care settings. It incorporates further published UK guidance, feedback from UK healthcare professionals and affected families and, importantly, also international guidance and expertise

An interpretation of the new international MAP guideline for the management of Milk Allergy in Primary Care.  
Netts P, Michaelis LJ.
Clin Transl Allergy 2017;734

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Allergy and Intolerance Abstracts
Cannabis-associated asthma and allergies.
To review the evidence of asthma and allergic diseases associated with the use of marijuana, we conducted a search of English, Spanish, and Portuguese medical using the search terms asthma, allergy, marijuana, marihuana, and cannabis. Several papers have shown the relationship between marijuana use and increase in asthma and other allergic diseases symptoms, as well as the increased frequency of medical visits. Although smoking of marijuana may cause respiratory symptoms, there is a need for more studies to elucidate many aspects in allergic asthma patients, especially considering the long-term use of the drug.

Cannabis-associated asthma and allergies.  
Chatkin JM, Zani-Silva L, Ferreira I, Zamel N.
Clin Rev Allergy Immunol 2017 Sep 18;

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Allergy and Intolerance Abstracts
Detection of the peanut allergens Ara h 2 and Ara h 6 in human breast milk: Development of 2 sensitive and specific sandwich ELISA assays.
Well-characterized and highly sensitive detection systems for the reliable determination of peanut allergens in breast milk are mandatory. The Ara h 2 ELISA revealed a limit of detection (LOD) of 1.3 ng Ara h 2/mL and a quantification range of 2.3-250 ng/mL, the Ara h 6 ELISA showed an LOD of 0.7 ng/mL and a working range of 1.1-14.4 ng/mL. The assays showed no relevant cross-reactivity against other potentially cross-reactive legume, seed, and tree nut extracts (<0.01%, except for Ara h 1 in the Ara h 2 ELISA <0.1%). Ara h 2 was detectable in breast milk samples from 14/40 (35%) of the participants in concentrations from 2.3 to 184 ng/mL, Ara h 6 appeared in 9/40 (22.5%) of the lactating mothers between 1.1 and 9.7 ng/mL, and 1 highly positive sample with 79 ng/mL. Both allergens appeared at the same time points, but Ara h 6 in lower concentrations than Ara h 2.

Detection of the peanut allergens Ara h 2 and Ara h 6 in human breast milk: Development of 2 sensitive and specific sandwich ELISA assays.  
Schocker F, Scharf A, Kull S, Jappe U.
Int Arch Allergy Immunol 2017 Sep 27;174(1):17-25

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Allergy and Intolerance Abstracts
Diagnostic value of oral challenge testing in the diagnosis of macrolide hypersensitivity.
Our results suggested that drug provocation tests are the only reliable method to predict macrolide hypersensitivity as well as to detect cross-reactivity between macrolides

Diagnostic value of oral challenge testing in the diagnosis of macrolide hypersensitivity.  
Unal D, Demir S, Gelincik A, Olgac M, Coskun R, Colakoglu B, Buyukozturk S.
J Allergy Clin Immunol Pract 2017 Sep 8;

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Allergy and Intolerance Abstracts
A new allergen family involved in pollen food associated syndrome: snakin/gibberellin regulated proteins.
At least two pollen food associated syndromes were described with cypress pollen allergy involving peach and citrus. Snakin/gibberellin regulated proteins are described herein to be the cross-reactive allergens between Cupressus sempervirens pollen and fruit/vegetables.

At least two pollen food associated syndromes were described with cypress pollen allergy involving peach and citrus. Snakin/gibberellin regulated proteins are described herein to be the cross-reactive allergens between Cupressus sempervirens pollen and fruit/vegetables. In Southern France a pollen food associated syndrome (PFAS) was described involving cypress pollen and peach and/or citrus sensitizations inducing mainly oral syndrome but also urticaria and angioedema. Up to now, the cross-reactive allergen at the basis of this syndrome has not yet been unraveled. Besides the four groups of allergens already described in the various Cupressaceae species, an as yet unidentified basic allergen of 14kDa (BP14), over expressed in Cupressus sempervirens pollen and different from a lipid transfer protein, was found to sensitize 37% of cypress pollen allergic patients (CPAP) in Southern France. The BP14 IgE epitopes are not related to cross-reactive carbohydrate determinants, are heat resistant but destroyed under reducing conditions.

To identify BP14, proteins extracted from C. sempervirens pollen were assessed. Except a contaminant peptide of polygalacturonase, two overlapping peptides of the gibberellin-regulated protein (GRP) peamaclein (Pru p 7 from peach) were found. One very similar peptide of the GRP of Theobroma cacao was identified. The identified peptides were evidenced in proteins of the snakin/GRP family from various plant species. One of them, the snakin-1 from potato, produced in recombinant form sharing 82.5% sequence identity with Pru p 7 and 79.4 % with the GRP of Theobroma cacao.

Out of 30 CPAP sera, all of those expressing IgE to BP14 exhibited IgE reactivity to snakin-1 (n=15). No IgE binding was observed in 14 out of the 15 sera tested from BP14-negative CPAP. One serum, tested negative for BP14 was positive for snakin-1. Similarly to BP14, the reduction of snakin-1 resulted in decreased apparent molecular mass and abolished IgE reactivity. Direct and crossed inhibition binding assays show that BP14 allergen from C. sempervirens is cross-reactive with a member of the snakin/GRP protein family while also displaying some specific IgE epitopes.

A new allergen family involved in pollen food associated syndrome: snakin/gibberellin regulated proteins.  
Senechal H, Santrucek J, Melcova M, Svoboda P, Zidkova J, Charpin D, Guilloux L, Shahali Y, Selva MA, Couderc R, Aizawa T, Poncet P.
J Allergy Clin Immunol 2017 Aug 3;

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Allergy and Intolerance Abstracts
Aspergillus fumigatus alkaline protease 1 (Alp1/Asp f13) in the airways correlates with asthma severity.
This article argues that Aspergillus fumigatus alkaline protease 1 (Alp1/Asp f13) in the airways correlates with asthma severity.

Aspergillus fumigatus alkaline protease 1 (Alp1/Asp f13) in the airways correlates with asthma severity.  
Basu T, Seyedmousavi S, Sugui JA, Balenga N, Zhao M, Kwon Chung KJ, Biardel S, Laviolette M, Druey KM.
J Allergy Clin Immunol 2017 Sep 4;

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Allergy and Intolerance Abstracts
Life after LEAP: How to implement advice on introducing peanuts in early infancy.
The increase in food allergies worldwide has led to mounting concern among healthcare providers, families, schools, and the food industry. Of particular interest is the growing prevalence of peanut allergy. The Learning Early About Peanut Allergy (LEAP) study confirms that the early introduction of peanut significantly decreases the risk of developing peanut allergy among high-risk children. However, a number of issues, such as a unified definition of high risk and whether or not to screen patients before peanut introduction, remain. This article will review the LEAP findings and the new peanut allergy prevention guidelines, and then briefly discuss recommendations on the introduction of other allergenic foods based on results from other food allergy prevention randomised controlled trials.

Life after LEAP: How to implement advice on introducing peanuts in early infancy.  
Fleischer DM.
J Paediatr Child Health 2017 Mar;53(S1):3-9

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Allergy and Intolerance Abstracts
Association of household cleaning agents and disinfectants with asthma in young German adults.
Our results support the hypothesis of an association between the use of cleaning products and elevated risks for asthma and wheezing in young adults at the start of working life

Association of household cleaning agents and disinfectants with asthma in young German adults.  
Weinmann T, Gerlich J, Heinrich S, Nowak D, Mutius EV, Vogelberg C, Genuneit J, Lanzinger S, Al-Khadra S, Lohse T, Motoc I, Walter V, Radon K.
Occup Environ Med 2017 Sep;74(9):684-690

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Allergy and Intolerance Abstracts
Predicting occupational asthma and rhinitis in bakery workers referred for clinical evaluation.
The objective of this study was to develop diagnostic models predicting baker's asthma and rhinitis among bakery workers at high risk of sensitisation to bakery allergens referred to a specialised clinic. As part of a medical surveillance programme, clinical evaluation was performed on 436 referred Dutch bakery workers at high risk for sensitisation to bakery allergens. Multivariable logistic regression analyses were developed to identify the predictors of onset of baker's asthma and rhinitis using a self-administered questionnaire and compared using a structured medical history. The probability of allergic asthma and rhinitis in referred bakers could be estimated by diagnostic models based on both a self-administered questionnaire and by taking a structured medical history.

Predicting occupational asthma and rhinitis in bakery workers referred for clinical evaluation.  
Jonaid BS, Rooyackers J, Stigter E, Portengen L, Krop E, Heederik D.
Occup Environ Med 2017 Aug;74(8):564-572

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Allergy and Intolerance Abstracts
Occupational allergy to fruit flies (Drosophila melanogaster) in laboratory workers.
Drosophila melanogaster (the 'fruit fly') is commonly used in genetic research, but there is only one report of IgE-associated allergy in exposed workers. 4 newly identified cases prompted us to examine the extent of this problem in a university laboratory. We surveyed 286 employees working in a department carrying out research involving D. melanogaster. Sensitisation was assessed by specific IgE measurement in serum and examined in relation to symptoms and to estimated exposure to fruit flies. The overall prevalence of specific sensitisation was 6% with a clear relationship to increasing frequency/intensity of exposure. Work-related eye/nose, chest or skin symptoms were reported by substantial proportions of participants but for most of these there was no evidence of specific sensitisation to fruit fly. The overall prevalence of any work-related symptoms and sensitisation was 2.4%, rising to 7.1% in those working in high exposure groups.

Occupational allergy to fruit flies (Drosophila melanogaster) in laboratory workers.  
Jones M, Blair S, MacNeill S, Welch J, Hole A, Baxter P, Cullinan P.
Occup Environ Med 2017 Jun;74(6):422-425

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Allergy and Intolerance Abstracts
Development of a prediction model for severe wheat allergy.
Oral food challenges (OFCs) in patients with severe food allergies, defined as low-threshold and severe reactions, carry a risk of triggering anaphylaxis. To predict such severe reactions before OIT, we previously reported prediction models consisting of multiple factors for hen's egg and cow's milk allergy. The authors discuss a model for wheat allergy.

Development of a prediction model for severe wheat allergy.  
Sugiura S, Matsui T, Furuta T, Sasaki K, Kando N, Ito K.
Pediatr Allergy Immunol 2017 Sep 11;

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Allergy and Intolerance Abstracts
Oral challenge without skin tests in children with non-severe betalactam hypersensitivity: time to change the paradigm?
Suspected allergy to penicillins and cephalosporins is very common in childhood. After a proper evaluation, allergy will be confirmed only in a small portion of them. Intradermal tests are usually part of the allergy workup, but they are painful for children and time-consuming, and their role has been debated. A systematic review found only two studies reporting a positive predictive value of skin tests in children of 36% and 33%, respectively, leading to a high rate of inaccurate diagnosis. Moreover, considering that skin tests are negative in more than 90-95% of cases, an oral provocation test (OPT) is finally needed to confirm tolerance in most of these children. Positive OPT are rare and even where children demonstrate reproducible signs on challenge, they rarely constitute immediate or serious symptoms. Therefore, OPT to the index antibiotic without skin tests are increasingly being considered an accepted procedure for children with a suspected mild non-immediate reaction related to a betalactam antibiotic. Furthermore, a recent research has taken the same approach including children with suspected mild immediate reactions, with similar safety and positive results. In the light of recent evidence highlighted, it is now the time for large and multicentric studies to confirm that OPT with the index antibiotic, without skin tests, are safe and convenient for children with a history of a mild reaction with a betalactam antibiotic before it can be recommended in pediatric allergy guidelines.

Oral challenge without skin tests in children with non-severe betalactam hypersensitivity: time to change the paradigm?  
Moral L, Caubet JC.
Pediatr Allergy Immunol 2017 Sep 11;

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Allergy and Intolerance Abstracts
The impact of food allergens on airway responsiveness in schoolchildren with asthma
Despite the growing evidence of a possible link between asthma and food allergy (FA), so far, the involvement of food in inducing respiratory symptoms has not been fully evaluated. The objective of this study was to evaluate the impact of food allergens on respiratory symptoms and bronchial reactivity (BHR) in schoolchildren with asthma. The initial study group consisted of 362 children with asthma. In the end, 22 children with concomitant FA, and 18 without FA, were selected to participate in the study. The food-induced asthmatic reactions were observed in nine (2.5%) out of all 362 children with asthma. Increase of BHR after DBPCFC was seen in 17 (4.7%) children with asthma. Although food allergens are a rare trigger of food-induced asthmatic reactions in schoolchildren with asthma, they could enhance BHR, despite a lack of evident clinical respiratory signs and decreased in FEV1 values after food challenge.

The impact of food allergens on airway responsiveness in schoolchildren with asthma: A DBPCFC study.  
Krogulska A, Dynowski J, Jedrzejczyk M, Sardecka I, Malachowska B, Wasowska-Krolikowska K.
Pediatr Pulmonol 2016 Aug;51(8):787-795

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Allergy and Intolerance Abstracts
Critical Issues in Food Allergy: A National Academies Consensus Report.
The National Academies of Sciences, Engineering, and Medicine convened an expert, ad hoc committee to examine critical issues related to food allergy. The authors of the resulting report, "Finding a Path to Safety in Food Allergy: Assessment of the Global Burden, Causes, Prevention, Management, and Public Policy," evaluated the scientific evidence on the prevalence, diagnosis, prevention, and management of food allergy and made recommendations to bring about a safe environment for those affected. The committee recommended approaches to monitor prevalence, explore risk factors, improve diagnosis, and provide evidence-based health care. Regarding diagnostics, emphasis was placed on utilizing allergy tests judiciously in the context of the medical history because positive test results are not, in isolation, diagnostic. Evidence-based prevention strategies were advised (for example, a strategy to prevent peanut allergy through early dietary introduction). The report encourages improved education of stakeholders for recognizing and managing as well as preventing allergic reactions, including an emphasis on using intramuscular epinephrine promptly to treat anaphylaxis. The report recommends improved food allergen labeling and evaluation of the need for epinephrine autoinjectors with a dosage appropriate for infants. The committee recommended policies and guidelines to prevent and treat food allergic reactions in a various settings and suggested research priorities to address key questions about diagnostics, mechanisms, risk determinants, and management. Identifying safe and effective therapies is the ultimate goal. This article summarizes the key findings from the report and emphasizes recommendations for actions that are applicable to pediatricians and to the American Academy of Pediatrics.

Critical Issues in Food Allergy: A National Academies Consensus Report.  
Sicherer SH, Allen K,, Lack G,, Taylor SL, Donovan SM7, Oria M8.
Pediatrics 2017 Jul 24. pii: e20170194.

Abstract

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Allergy and Intolerance Abstracts
Case report of subcutaneous nodules and sterile abscesses due to delayed type hypersensitivity to aluminum-containing vaccines.
We present a case of persistent subcutaneous nodules and sterile abscesses in the setting of delayed type hypersensitivity to aluminum, confirmed by patch testing and recurrence on re-exposure. We review sources of aluminum in common immunizations, principles for treatment, and strategies for management of future vaccinations for this patient

Case report of subcutaneous nodules and sterile abscesses due to delayed type hypersensitivity to aluminum-containing vaccines.  
Lauren CT, Belsito DV, Morel KD, LaRussa P.
Pediatrics 2016 Oct;138(4):

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Allergy and Intolerance Abstracts
Thumb-sucking, nail-biting, and atopic sensitization, asthma, and hay fever.
This study concludes that children who suck their thumbs or bite their nails are less likely to have atopic sensitization in childhood and adulthood. The hygiene hypothesis suggests that early-life exposure to microbial organisms reduces the risk of developing allergies. Thumb-sucking and nail-biting are common childhood habits that may increase microbial exposures. The authors tested the hypothesis that children who suck their thumbs or bite their nails have a lower risk of developing atopy, asthma, and hay fever in a population-based birth cohort followed to adulthood.

Thumb-sucking, nail-biting, and atopic sensitization, asthma, and hay fever.  
Lynch SJ, Sears MR, Hancox RJ.
Pediatrics 2016 Aug;138(2):

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Allergy and Intolerance Abstracts
Cow's milk allergy and bone mineral density in prepubertal children.
The objectives of this study were to compare bone mineral density (BMD), vitamin D status, and dietary intakes of calcium and vitamin D between prepubertal children with persistent CMA and those with non-cow's milk food allergies (NCMA) as control subjects and to assess the use of and compliance to calcium and vitamin D supplementation among children with persistent CMA. The study concludes that these prepubertal children with persistent CMA had lower lumbar spine BMD z scores than children with NCMA, which likely resulted from lower calcium intake.

Cow's milk allergy and bone mineral density in prepubertal children.  
Mailhot G, Perrone V, Alos N, Dubois J, Delvin E, Paradis L, Des RA.
Pediatrics 2016 May;137(5):

Index
Allergy and Intolerance Abstracts
Myths and misconceptions concerning contrast media-induced anaphylaxis: a narrative review.
Contrast-enhanced radiological examinations are an increasingly important diagnostic tool in modern medicine. All approved and available contrast media (iodinated and gadolinium-based) are safe compounds that are well-tolerated by most patients. However, a small percentage of patients exhibit contrast medium-induced adverse drug reactions that are dose-dependent and predictable (type A) or an even smaller cohort experience so-called type B (dose-independent, non-predictable). To increase patients' safety, recommendations/guidelines have been put forth in the literature and advice passed down informally by radiologists in practice to ensure contrast media safety. Through these, both reasonable suggestions as well as misinterpretations and myths (such as the misleading terms 'allergy-like' reactions, and 'iodine-allergy', the wrong assumption that the initial contact to a contrast medium could not induce an allergy, the estimation that an anti-allergy premedication could suppress all possible adverse reactions, and interleukin-2 as a risk/trigger for contrast medium adverse events) have arisen. Since the latter are not only unhelpful but also potentially reduce patients' safety, such myths and misconceptions are the focus of this review

Myths and misconceptions concerning contrast media-induced anaphylaxis: a narrative review.  
Bohm I, Morelli J, Nairz K, Silva Hasembank KP, Heverhagen JT.
Postgrad Med 2017 Mar;129(2):259-266

Click to view abstract

Index
Allergy and Intolerance Abstracts
Angio-oedema associated with colistin.
A 50-year-old woman known to have type 1 diabetes mellitus presented with a rare case of angio-oedema associated with colistin use. The angio-oedema was temporally associated with the use and discontinuation of colistin with the reasonable exclusion of important differential diagnoses. Pseudoallergy may be a probable underlying mechanism. However, we cannot exclude the possibility of hereditary angio-oedema type 2 or 3, or that her concomitant medications (particularly enalapril) and her renal impairment contributed to the risk and severity of her angio-oedema

Angio-oedema associated with colistin.  
Abulfathi AA, Greyling T, Makiwane M, Esser M, Decloedt E.
S Afr Med J 2016 Sep 4;106(10):990-991

Click to view abstract

Index

Allergen-, Food allergy-, Intolerance-related articles

Assessment of allergen-specific IgE by immunoblotting method in atopic dermatitis.  
Bonyadi MR, Hassanzadeh D, Seyfizadeh N, Borzoueisileh S.
Eur Ann Allergy Clin Immunol 2017 Sep;49(5):213-219
Click to view abstract

Long-term course of serum total and free IgE levels in severe asthma patients treated with omalizumab.  
Gon Y, Ito R, Maruoka S, Mizumura K, Kozu Y, Hiranuma H, Iida Y, Hikichi M, Shikano S, Hashimoto S.
Allergol Int 2017 Sep 16;

Exposure amount and timing of solar irradiation during pregnancy and the risk of sensitization in children.  
Koh HY, Cho E, Lee SY, Kim WK, Park YM, Kim J, Ahn K, Lee SW, Kim MA, Hahm MI, Chae Y, Lee KJ, Kwon HJ, Han MY.
Allergol Int 2017 Sep 4;
Click to view abstract

Hand eczema as a risk factor for food allergy among occupational kitchen workers.  
Minami T, Fukutomi Y, Sekiya K, Akasawa A, Taniguchi M.
Allergol Int 2017 Sep 2;
Click to view abstract

Serine protease allergen favours Th2 responses via PAR-2 and STAT-3 activation in murine model.  
Agrawal K, Arora N.
Allergy 2017 Sep 20;
Click to view abstract

Hen's egg allergen in house and bed dust is significantly increased after hen's egg consumption-A pilot study.  
Trendelenburg V, Tschirner S, Niggemann B, Beyer K.
Allergy 2017 Sep 2;
Click to view abstract

Clinical outcomes following inpatient penicillin allergy testing: A systematic review and meta-analysis.  
Sacco KA, Bates A, Brigham TJ, Imam JS, Burton MC.
Allergy 2017 Sep;72(9):1288-1296
Click to view abstract

Characterization of maize chitinase-A, a tough allergenic molecule.  
Volpicella M, Leoni C, Fanizza I, Distaso M, Leoni G, Farioli L, Naumann T, Pastorello E, Ceci LR.
Allergy 2017 Sep;72(9):1423-1429
Click to view abstract

Pru p 3, a marker allergen for lipid transfer protein sensitization also in Central Europe.  
Mothes-Luksch N, Raith M, Stingl G, Focke-Tejkl M, Razzazi-Fazeli E, Zieglmayer R, Wohrl S, Swoboda I.
Allergy 2017 Sep;72(9):1415-1418
Click to view abstract

Association of aeroallergen sensitization and atopic disease in the Sonoran Desert.  
Buckley RD, Carr TF.
Allergy Asthma Proc 2017 Sep 1;38(5):370-375
Click to view abstract

Der p 1 and Der p 2 specific immunoglobulin E measurement for diagnosis of Dermatophagoides pteronyssinus allergy: A systematic review and meta-analysis.  
Tian M, Zhou Y, Zhang W, Cui Y.
Allergy Asthma Proc 2017 Sep 1;38(5):333-342
Click to view abstract

Characteristics of drug-induced anaphylaxis in children and adolescents.  
Cavkaytar O, Karaatmaca B, Cetinkaya PG, Esenboga S, Arik YE, Sahiner UM, Sekerel BE, Soyer O.
Allergy Asthma Proc 2017 Sep 1;38(5):56-63
Click to view abstract

Age-Based Causes and Clinical Characteristics of Immediate-Type Food Allergy in Korean Children.  
Jeong K, Kim J, Ahn K, Lee SY, Min TK, Pyun BY, Kim YH, Kim KW, Sohn MH, Kim KE, Jang GC, Song TW, Kim JH, Jeon YH, Lee YJ, Park YM, Yum HY, Kim HH, Kim WK, Lee S.
Allergy Asthma Immunol Res 2017 Sep;9(5):423-430
Click to view abstract

Monoclonal Antibodies to Recombinant Fag e 3 Buckwheat Allergen and Development of a Two-site ELISA for Its Quantification.  
Jeong KY, Park KH, Lee JH, Park JW.
Allergy Asthma Immunol Res 2017 Sep;9(5):417-422
Click to view abstract

Prevalence of Immediate-Type Food Allergy in Korean Schoolchildren in 2015: A Nationwide, Population-based Study.  
Kim M, Lee JY, Jeon HY, Yang HK, Lee KJ, Han Y, Kim YH, Kim J, Ahn K.
Allergy Asthma Immunol Res 2017 Sep;9(5):410-416
Click to view abstract

Oral food challenge outcomes in a pediatric tertiary care center.  
Abrams EM, Becker AB.
Allergy Asthma Clin Immunol 2017;1343
Click to view abstract

Passive blood anaphylaxis: subcutaneous immunoglobulins are a cause of ongoing passive anaphylactic reaction.  
Zdziarski P, Gamian A, Majda J, Korzeniowska-Kowal A.
Allergy Asthma Clin Immunol 2017;1341
Click to view abstract

Prevalence and clinical features of adverse food reactions in Portuguese children.  
Jorge A, Soares E, Sarinho E, Lorente F, Gama J, Taborda-Barata L.
Allergy Asthma Clin Immunol 2017;1340
Click to view abstract

The Effect of Cigarette Smoking on Lung Function in Young Adults with Asthma.  
Hancox RJ, Gray AR, Poulton R, Sears MR.
Am J Respir Crit Care Med 2016 Aug 1;194(3):276-284

Preventing severe asthma exacerbations in children. a randomized trial of mite-impermeable bedcovers.  
Murray CS, Foden P, Sumner H, Shepley E, Custovic A, Simpson A.
Am J Respir Crit Care Med 2017 Jul 15;196(2):150-158

Allergic sensitization in American children of Middle Eastern ethnicity at age 2.  
Havstad S, Sitarik AR, Johnson CC, Zoratti EM, Ownby DR, Levin AM, Wegienka G.
Ann Allergy Asthma Immunol 2017 Sep 20;

Multicenter prevalence of anaphylaxis in clinic-based oral food challenges.  
Akuete K, Guffey D, Israelsen RB, Broyles JM, Higgins LJ, Green TD, Naimi DR, MacGinnitie AJ, Vitalpur G, Minard CG, Davis CM.
Ann Allergy Asthma Immunol 2017 Sep 1;
Click to view abstract

Knowledge of food protein-induced enterocolitis syndrome among general pediatricians.  
Feuille E, Menon NR, Huang F, Greenhawt M, Nowak-Wegrzyn A.
Ann Allergy Asthma Immunol 2017 Sep;119(3):291-292

Sensitization profiles to peanut allergens across the United States.  
Valcour A, Jones JE, Lidholm J, Borres MP, Hamilton RG.
Ann Allergy Asthma Immunol 2017 Sep;119(3):262-266
Click to view abstract

Allergic sensitization and objective measures of sleep in urban school-aged children with asthma.  
Esteban CA, Everhart RS, Kopel SJ, Klein RB, Koinis-Mitchell D.
Ann Allergy Asthma Immunol 2017 Sep;119(3):238-245
Click to view abstract

The allergenicity of genetically modified foods from genetically engineered crops: A narrative and systematic review.  
Dunn SE, Vicini JL, Glenn KC, Fleischer DM, Greenhawt MJ.
Ann Allergy Asthma Immunol 2017 Sep;119(3):214-222

Single recombinant and purified major allergens and peptides: How they are made and how they change allergy diagnosis and treatment.  
Curin M, Garib V, Valenta R.
Ann Allergy Asthma Immunol 2017 Sep;119(3):201-209
Click to view abstract

Penicillin skin testing: The devil is in the details.  
Solensky R.
Ann Allergy Asthma Immunol 2017 Sep;119(3):199-200

Genetically modified products and food allergy: Beliefs, evidence, and opportunity.  
Compton J, Fanning JB, Nickels AS.
Ann Allergy Asthma Immunol 2017 Sep;119(3):198-199

Evaluating proteins for potential allergenicity using bioinformatic approaches.  
Dinakarpandian D, Dinakar C.
Ann Allergy Asthma Immunol 2017 Sep;119(3):197-198

Comparison of specific IgE detection by immunoblotting and fluorescence enzyme assay with in vivo skin prick test.  
Wongpiyabovorn J, Suratannon N, Boonmee S, Chatchatee P.
Asian Pac J Allergy Immunol 2017 Sep 17;
Click to view abstract

Pollen food allergy syndrome in Turkey: Clinical characteristics and evaluation of its association with skin test reactivity to pollens.  
Ozdemir SK, Ozguvarsigmalu S.
Asian Pac J Allergy Immunol 2017 Sep 17;
Click to view abstract

Trends in Occupations and Work Sectors Among Patients With Work-Related Asthma at a Canadian Tertiary Care Clinic.  
Gotzev S, Lipszyc JC, Connor D, Tarlo SM.
Chest 2016 Oct;150(4):811-818

Specific IgE to peanut 2S albumin Ara h 7 has a discriminative ability comparable to Ara h 2 and 6.  
Blankestijn MA, Otten HG, Suer W, Weimann A, Knol EF, Knulst AC.
Clin Exp Allergy 2017 Sep 14;
Click to view abstract

Aspirin is an enhancing factor for food-dependent exercise-induced anaphylaxis in children.  
Motomura C, Matsuzaki H, Ono R, Iwata M, Okabe K, Akamine Y, Wakatsuki M, Murakami Y, Taba N, Odajima H.
Clin Exp Allergy 2017 Sep 11;
Click to view abstract

Food challenges, the risks and benefits.  
Roberts G.
Clin Exp Allergy 2017 Sep;47(9):1106-1107

An interpretation of the new international MAP guideline for the management of Milk Allergy in Primary Care.  
Netts P, Michaelis LJ.
Clin Transl Allergy 2017;734
Click to view abstract

Cannabis-associated asthma and allergies.  
Chatkin JM, Zani-Silva L, Ferreira I, Zamel N.
Clin Rev Allergy Immunol 2017 Sep 18;
Click to view abstract

Genes Interacting with Occupational Exposures to Low Molecular Weight Agents and Irritants on Adult-Onset Asthma in Three European Studies.  
Rava M, Ahmed I, Kogevinas M, Le MN, Bouzigon E, Curjuric I, Dizier MH, Dumas O, Gonzalez JR, Imboden M, Mehta AJ, Tubert-Bitter P, Zock JP, Jarvis D, Probst-Hensch NM, Demenais F, Nadif R.
Environ Health Perspect 2017 Feb;125(2):207-214

Early Exposure to Traffic-Related Air Pollution, Respiratory Symptoms at 4 Years of Age, and Potential Effect Modification by Parental Allergy, Stressful Family Events, and Sex: A Prospective Follow-up Study of the PARIS Birth Cohort.  
Ranciere F, Bougas N, Viola M, Momas I.
Environ Health Perspect 2017 Apr;125(4):737-745

Practical approach to the treatment of NSAID hypersensitivity.  
Blanca-Lopez N, Perez-Alzate D, Canto G, Blanca M.
Expert Rev Clin Immunol 2017 Sep 19;1-11
Click to view abstract

Diagnostics of drug hypersensitivity reactions. [German]  
Mobs C, Pfutzner W.
Hautarzt 2017 Jan;68(1):19-28
Click to view abstract

Drug reactions. [German]  
Pfutzner W.
Hautarzt 2017 Jan;68(1):4

Cutaneous side effects of targeted cancer drugs. [German]  
Below J, Homey B, Gerber PA.
Hautarzt 2017 Jan;68(1):12-18
Click to view abstract

Adverse drug reactions in elderly people : First data from the Leipzig Research Center for Civilization Diseases (LIFE). [German]  
Treudler R, Walther F, Ahnert P, Simon JC.
Hautarzt 2017 Jan;68(1):5-11
Click to view abstract

Terbinafine : Drug-induced lupus erythematodes and triggering of psoriatic skin lesions. [German]  
Mayser P.
Hautarzt 2016 Sep;67(9):724-731

A mouse model of anaphylaxis and atopic dermatitis to salt-soluble wheat protein extract.  
Jin Y, Ebaugh S, Martens A, Gao H, Olson E, Ng PKW, Gangur V.
Int Arch Allergy Immunol 2017 Sep 27;174(1):7-16
Click to view abstract

Detection of the peanut allergens Ara h 2 and Ara h 6 in human breast milk: Development of 2 sensitive and specific sandwich ELISA assays.  
Schocker F, Scharf A, Kull S, Jappe U.
Int Arch Allergy Immunol 2017 Sep 27;174(1):17-25
Click to view abstract

Anaphylactic reaction due to cefuroxime axetil: A rare cause of anaphylaxis.  
Del Villar-Guerra P, Moreno Vicente-Arche B, Castrillo BS, Santana RC.
Int J Immunopathol Pharmacol 2016 Dec;29(4):731-733

Sunflower seed allergy.  
Ukleja-Sokolowska N, Gawronska-Ukleja E, Zbikowska-Gotz M, Bartuzi Z, Sokolowski L.
Int J Immunopathol Pharmacol 2016 Sep;29(3):498-503

Decreased sensitization to aeroallergens among southwestern Iranian male farmers.  
Moghtaderi M, Torab JM, Farjadian S, Ghassemi P, Hosseini TS.
Iran J Allergy Asthma Immunol 2017 Aug;16(4):307-312
Click to view abstract

Determination of the Most Common Indoor and Outdoor Allergens in 602 Patients with Allergic Symptoms Using Specific IgE Local Panel.  
Shokouhi SR, Pourpak Z, Fazlollahi MR, Shabani A, Kazemnejad A, Ebadi Z, Tayebi B, Darabi B, Movahedi M, Mahdaviani SA, Moin M.
Iran J Allergy Asthma Immunol 2017 Aug;16(4):298-306
Click to view abstract

Anaphylactic shock to H1 antihistamine drug bilastine: A case report.  
Coattrenec Y, Spoerl D, Jandus P, Harr T.
J Allergy Clin Immunol Pract 2017 Sep 19;

Chronic allergic contact dermatitis due to chlorhexidine.  
Watts TJ, Li PH, Ue KL, Haque R.
J Allergy Clin Immunol Pract 2017 Sep 19;

Severe anaphylaxis due to crocodile-meat allergy exhibiting wide cross-reactivity with fish allergens.  
Haroun-Diaz E, Blanca-Lopez N, Vazquez de la TM, Ruano FJ, Somoza Alvarez ML, Labrador HM, Bartolome B, Blanca M, Canto DG.
J Allergy Clin Immunol Pract 2017 Sep 8;

Diagnostic value of oral challenge testing in the diagnosis of macrolide hypersensitivity.  
Unal D, Demir S, Gelincik A, Olgac M, Coskun R, Colakoglu B, Buyukozturk S.
J Allergy Clin Immunol Pract 2017 Sep 8;
Click to view abstract

Eosinophilic esophagitis linked to pollen food syndrome.  
Hunter H, Wong T, Winstanley A, Till SJ.
J Allergy Clin Immunol Pract 2017 Sep 6;

Food protein-induced enterocolitis syndrome to peanut with early introduction: a clinical dilemma.  
Robbins KA, Ackerman OR, Carter CA, Uygungil B, Sprunger A, Sharma HP.
J Allergy Clin Immunol Pract 2017 Sep 6;

A new allergen family involved in pollen food associated syndrome: snakin/gibberellin regulated proteins.  
Senechal H, Santrucek J, Melcova M, Svoboda P, Zidkova J, Charpin D, Guilloux L, Shahali Y, Selva MA, Couderc R, Aizawa T, Poncet P.
J Allergy Clin Immunol 2017 Aug 3;

Effect of endotoxin and alum adjuvant vaccine on peanut allergy.  
Johnson-Weaver BT, McRitchie S, Mercier KA, Pathmasiri W, Sumner SJ, Chan C, Germolec D, Kulis M, Burks AW, Staats HF.
J Allergy Clin Immunol 2017 Sep 16;
Click to view abstract

Aspergillus fumigatus alkaline protease 1 (Alp1/Asp f13) in the airways correlates with asthma severity.  
Basu T, Seyedmousavi S, Sugui JA, Balenga N, Zhao M, Kwon Chung KJ, Biardel S, Laviolette M, Druey KM.
J Allergy Clin Immunol 2017 Sep 4;

Allergen sensitization in a birth cohort at midchildhood: Focus on food component IgE and IgG4 responses.  
Wilson JM, Workman L, Schuyler AJ, Rifas-Shiman SL, McGowan EC, Oken E, Gold DR, Hamilton RG, Platts-Mills TAE.
J Allergy Clin Immunol 2017 Sep 1;

Outbreak of immediate-type hydrolyzed wheat protein allergy due to a facial soap in Japan.  
Yagami A, Aihara M, Ikezawa Z, Hide M, Kishikawa R, Morita E, Chinuki Y, Fukutomi Y, Urisu A, Fukushima A, Itagaki Y, Sugiura SI, Tanaka H, Teshima R, Kato Z, Noguchi E, Nakamura M, Saito H.
J Allergy Clin Immunol 2017 Sep;140(3):879-881

Secondhand tobacco smoke and severity in wheezing children: Nasal oxidant stress and inflammation.  
Yilmaz O, Turkeli A, Onur E, Bilge S, Yuksel H.
J Asthma 2017 Sep 7;1-6
Click to view abstract

The influence of the microbiome on allergic sensitization to food.  
Plunkett CH, Nagler CR.
J Immunol 2017 Jan 15;198(2):581-589
Click to view abstract

From IgE to Omalizumab.  
Kawakami T, Blank U.
J Immunol 2016 Dec 1;197(11):4187-4192
Click to view abstract

Reference Values and Utility of Serum Total Immunoglobulin E for Predicting Atopy and Allergic Diseases in Korean Schoolchildren.  
Kim HY, Choi J, Ahn K, Hahm MI, Lee SY, Kim WK, Chae Y, Park YM, Han MY, Lee KJ, Kwon HJ, Kim S, Yoo H, Kim J.
J Korean Med Sci 2017 May;32(5):803-809
Click to view abstract

Life after LEAP: How to implement advice on introducing peanuts in early infancy.  
Fleischer DM.
J Paediatr Child Health 2017 Mar;53(S1):3-9
Click to view abstract

Celiac Disease and Nonceliac Gluten Sensitivity: A Review.  
Leonard MM, Sapone A, Catassi C, Fasano A.
JAMA 2017 Aug 15;318(7):647-656
Click to view abstract

Penicillin allergy is not necessarily forever.  
Trubiano JA, Adkinson NF, Phillips EJ.
JAMA 2017 Jul 4;318(1):82-83

Gibberellin-regulated protein in Japanese apricot is an allergen cross-reactive to Pru p 7.  
Inomata N, Miyakawa M, Aihara M.
Miscellaneous Immun Inflamm Dis 2017 Jul 6.
Abstract

Pets: Millennia together.  
Mestel R.
Nature 2017 Mar 29;543(7647):S42-S43

Microbiome: Puppy power.  
Gupta S.
Nature 2017 Mar 29;543(7647):S48-S49

Association of household cleaning agents and disinfectants with asthma in young German adults.  
Weinmann T, Gerlich J, Heinrich S, Nowak D, Mutius EV, Vogelberg C, Genuneit J, Lanzinger S, Al-Khadra S, Lohse T, Motoc I, Walter V, Radon K.
Occup Environ Med 2017 Sep;74(9):684-690
Click to view abstract

Predicting occupational asthma and rhinitis in bakery workers referred for clinical evaluation.  
Jonaid BS, Rooyackers J, Stigter E, Portengen L, Krop E, Heederik D.
Occup Environ Med 2017 Aug;74(8):564-572
Click to view abstract

Occupational allergy to fruit flies (Drosophila melanogaster) in laboratory workers.  
Jones M, Blair S, MacNeill S, Welch J, Hole A, Baxter P, Cullinan P.
Occup Environ Med 2017 Jun;74(6):422-425
Click to view abstract

Epidemiology of occupational hypersensitivity pneumonitis; reports from the SWORD scheme in the UK from 1996 to 2015.  
Barber CM, Wiggans RE, Carder M, Agius R.
Occup Environ Med 2017 Jul;74(7):528-530
Click to view abstract

IgE reactivity to shrimp allergens in infants and their cross-reactivity to house dust mite.  
Kamath SD, Johnston EB, Iyer S, Schaeffer PM, Koplin J, Allen K, Lopata AL.
Pediatr Allergy Immunol 2017 Aug 7;

A case of a 7-year-old girl with late-onset anaphylaxis to fermented soybeans.  
Mori S, Tsumagari S, Kurihara K.
Pediatr Allergy Immunol 2017 Aug;28(5):501-502

Development of a prediction model for severe wheat allergy.  
Sugiura S, Matsui T, Furuta T, Sasaki K, Kando N, Ito K.
Pediatr Allergy Immunol 2017 Sep 11;
Click to view abstract

Oral challenge without skin tests in children with non-severe betalactam hypersensitivity: time to change the paradigm?  
Moral L, Caubet JC.
Pediatr Allergy Immunol 2017 Sep 11;
Click to view abstract

Full breastfeeding and allergies from infancy until adolescence in the GINIplus cohort.  
Filipiak-Pittroff B, Koletzko S, Kramer U, Standl M, Bauer CP, Berdel D, von BA.
Pediatr Allergy Immunol 2017 Sep 7;
Click to view abstract

Growth curves of 'normal' serum total IgE levels throughout childhood: A quantile analysis in a birth cohort.  
Sacco C, Perna S, Vicari D, Alfo M, Bauer CP, Hoffman U, Forster J, Zepp F, Schuster A, Wahn U, Keil T, Lau S, Matricardi PM.
Pediatr Allergy Immunol 2017 Sep;28(6):525-534
Click to view abstract

The impact of food allergens on airway responsiveness in schoolchildren with asthma: A DBPCFC study.  
Krogulska A, Dynowski J, Jedrzejczyk M, Sardecka I, Malachowska B, Wasowska-Krolikowska K.
Pediatr Pulmonol 2016 Aug;51(8):787-795
Click to view abstract

Critical Issues in Food Allergy: A National Academies Consensus Report.  
Sicherer SH, Allen K,, Lack G,, Taylor SL, Donovan SM7, Oria M8.
Pediatrics 2017 Jul 24. pii: e20170194.
Abstract

Anaphylactic reactions to novel foods: Case report of a child with severe crocodile meat allergy.  
Ballardini N, Nopp A, Hamsten C, Vetander M, Melén E, Nilsson C, Ollert M, Flohr C, Kuehn A, van Hage M.
Pediatrics 2017 Apr;139(4):

Use of Food Allergy Panels by Pediatric Care Providers Compared With Allergists.  
Stukus DR, Kempe E, Leber A, Thornton D, Scherzer R.
Pediatrics 2016 Dec;138(6):

Case report of subcutaneous nodules and sterile abscesses due to delayed type hypersensitivity to aluminum-containing vaccines.  
Lauren CT, Belsito DV, Morel KD, LaRussa P.
Pediatrics 2016 Oct;138(4):

Thumb-sucking, nail-biting, and atopic sensitization, asthma, and hay fever.  
Lynch SJ, Sears MR, Hancox RJ.
Pediatrics 2016 Aug;138(2):

Socioeconomic disparities in the economic impact of childhood food allergy.  
Bilaver LA, Kester KM, Smith BM, Gupta RS.
Pediatrics 2016 May;137(5):

Cow's milk allergy and bone mineral density in prepubertal children.  
Mailhot G, Perrone V, Alos N, Dubois J, Delvin E, Paradis L, Des RA.
Pediatrics 2016 May;137(5):

Myths and misconceptions concerning contrast media-induced anaphylaxis: a narrative review.  
Bohm I, Morelli J, Nairz K, Silva Hasembank KP, Heverhagen JT.
Postgrad Med 2017 Mar;129(2):259-266
Click to view abstract

Angio-oedema associated with colistin.  
Abulfathi AA, Greyling T, Makiwane M, Esser M, Decloedt E.
S Afr Med J 2016 Sep 4;106(10):990-991
Click to view abstract

Development of an in vitro method to estimate the sensitization induction level of contact allergens.  
Galbiati V, Papale A, Marinovich M, Gibbs S, Roggen E, Corsini E.
Toxicol Lett 2017 Apr 5;2711-11
Click to view abstract

Allergic rhinoconjunctivitis caused by occupational exposure to ginger. [Danish]  
Schmidt J, Dahl S, Sherson DL.
Ugeskr Laeger 2015 Jul 6;177(28):
Click to view abstract

The medical and scientific responsibility of pollen information service. [German]  
Bastl K, Berger M, Bergmann KC, Kmenta M, Berger U.
Wien Klin Wochenschr 2017 Jan;129(1-2):70-74
Click to view abstract

The grass pollen season 2015: a proof of concept multi-approach study in three different European cities.  
Kmenta M, Bastl K, Berger U, Kramer MF, Heath MD, Patsi S, Pessi AM, Saarto A, Werchan B, Werchan M, Zetter R, Bergmann KC.
World Allergy Organ J 2017;10(1):31
Click to view abstract


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